DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and Wsb1

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_062627.3	Gene:	Wsb1 / 78889	MGIID:	1926139	Length:	421	Species:	Mus musculus

Alignment Length:	330	Identity:	61/330 - (18%)
Similarity:	119/330 - (36%)	Gaps:	117/330 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WSIIDADFSPNGEHFAYSTWSRSLFIMP----------------------------VNGGEDDCQ 211
            |::.   |:|:|.:||:|...|.:.::|                            .|||:.
Mouse    38 WTVA---FAPDGSYFAWSQGYRIVKLVPWSQCRKNFLLHGSKNVTNSSCLKLARQNSNGGQK--- 96

  Fly   212 WIDVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQILRTHRMPGKDVNSVCFLH 276
                |..|.|.:        ..||.:...:..|:|.....|..|   :..||          |..
Mouse    97 ----NKPPEHVI--------DCGDIVWSLAFGSSVPEKQSRCVN---IEWHR----------FRF 136

  Fly   277 DKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVL-SNSKDQS 340
            .:|..::..|.::|.:|::|:.|       .|.:.:.:.|.:.:..:....||..:| |.|:|::
Mouse   137 GQDQLLLATGLNNGRIKIWDVYT-------GKLLLNLVDHIEMVRDLTFAPDGSLLLVSASRDKT 194

  Fly   341 IKIWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLR 405
            :::||::...||....|:.|     .|.|.....|            |.|::
Mouse   195 LRVWDLKDDGNMVKVLRAHQ-----NWVYSCAFSP------------DCSML------------- 229

  Fly   406 AKFSPMEQTGQRYIYTGCATG---RIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWD 467
                             |:.|   .:.::::....:...:|||...:...|:.||.:.:.:.|:|
Mouse   230 -----------------CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYD 277

  Fly   468 THVHL 472
            |.|::
Mouse   278 TRVYV 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	58/323 (18%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	61/330 (18%)
		WD40 repeat	178..220	CDD:293791	12/69 (17%)
		WD40 repeat	225..260	CDD:293791	6/34 (18%)
		WD40 repeat	270..314	CDD:293791	8/43 (19%)
		WD40 repeat	323..395	CDD:293791	17/72 (24%)
		WD40 repeat	403..443	CDD:293791	2/42 (5%)
Wsb1	NP_062627.3	WD 1	124..165		12/60 (20%)
		WD40	135..388	CDD:238121	37/202 (18%)
		WD40	<139..382	CDD:225201	37/198 (19%)
		WD 2	168..208		11/39 (28%)
		WD40 repeat	174..212	CDD:293791	10/37 (27%)
		WD 3	212..251		8/85 (9%)
		WD40 repeat	217..253	CDD:293791	6/77 (8%)
		WD 4	254..293		9/29 (31%)
		WD40 repeat	261..299	CDD:293791	7/22 (32%)
		WD 5	309..346
		WD40 repeat	314..353	CDD:293791
		SOCS	382..420	CDD:295349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900