DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and Wsb2

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_067514.2	Gene:	Wsb2 / 59043	MGIID:	2144041	Length:	404	Species:	Mus musculus

Alignment Length:	322	Identity:	60/322 - (18%)
Similarity:	116/322 - (36%)	Gaps:	114/322 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WSIIDADFSPNGEHFAYS---------TW--------------SRSLFIMPVNGGEDDCQWIDVN 216
            ||:.   |||:|..||:|         .|              |||....|...|....:.:|..
Mouse    30 WSVA---FSPDGSWFAWSQGHCVVKLVPWPLEEQFIPKGFEAKSRSSKNDPKGRGSLKEKTLDCG 91

  Fly   217 GLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQILRTHRMPGKDVNSVCFLHDKDPN 281
            .:      ::.|.:||...                 ..:.::...|.....||:.:
Mouse    92 QI------VWGLAFSPWPS-----------------PPSRKLWARHHPQAPDVSCL--------- 124

  Fly   282 VIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVL-SNSKDQSIKIWD 345
            ::..|.:||.:|:::::|.....:||       ||.|.:..:.....|..:| |.|:|::::|||
Mouse   125 ILATGLNDGQIKIWEVQTGLLLLNLS-------GHQDVVRDLSFTPSGSLILVSASRDKTLRIWD 182

  Fly   346 IRQPSNMRNRSRSRQQV--DPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLRAKF 408
            :       |:...:.||  ....|.|..:..|            |.|::
Mouse   183 L-------NKHGKQIQVLSGHLQWVYCCSISP------------DCSML---------------- 212

  Fly   409 SPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHV 470
              ....|::.::         ::.:.:..:...:|||::.:...|:.||.:.:|:.|:||.|
Mouse   213 --CSAAGEKSVF---------LWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSV 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	57/317 (18%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	60/322 (19%)
		WD40 repeat	178..220	CDD:293791	14/64 (22%)
		WD40 repeat	225..260	CDD:293791	3/34 (9%)
		WD40 repeat	270..314	CDD:293791	7/43 (16%)
		WD40 repeat	323..395	CDD:293791	16/74 (22%)
		WD40 repeat	403..443	CDD:293791	1/39 (3%)
Wsb2	NP_067514.2	WD40 repeat	29..89	CDD:293791	15/61 (25%)
		WD40	<30..182	CDD:330360	38/193 (20%)
		WD 1	105..148		8/51 (16%)
		WD40	121..360	CDD:238121	39/205 (19%)
		WD 2	151..191		12/46 (26%)
		WD40 repeat	157..195	CDD:293791	11/44 (25%)
		WD 3	195..234		6/77 (8%)
		WD40 repeat	200..236	CDD:293791	5/74 (7%)
		WD 4	237..276		10/27 (37%)
		WD40 repeat	244..289	CDD:293791	8/20 (40%)
		WD 5	291..330
		WD40 repeat	296..328	CDD:293791
		WD40 repeat	336..372	CDD:293791
		SOCS_WSB_SWIP	364..402	CDD:239702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900