DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and WSB2

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001265486.1	Gene:	WSB2 / 55884	HGNCID:	19222	Length:	421	Species:	Homo sapiens

Alignment Length:	319	Identity:	60/319 - (18%)
Similarity:	118/319 - (36%)	Gaps:	108/319 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDV---------------NGLPSHRL- 223
            ||:.   |||:|..||   ||:...|:.:.....:.|:|..               .|.|..:.
Human    47 WSVA---FSPDGSWFA---WSQGHCIVKLIPWPLEEQFIPKGFEAKSRSSKNETKGRGSPKEKTL 105

  Fly   224 ----AIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQILRTHRMPGKDVNSVCFLHDKDPNVII 284
                .::.|.:||...                 ..:.::...|.....||:.:         |:.
Human   106 DCGQIVWGLAFSPWPS-----------------PPSRKLWARHHPQVPDVSCL---------VLA 144

  Fly   285 AGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVL-SNSKDQSIKIWDIRQ 348
            .|.:||.:|:::::|.....:||       ||.|.:..:.....|..:| |.|:|::::|||:
Human   145 TGLNDGQIKIWEVQTGLLLLNLS-------GHQDVVRDLSFTPSGSLILVSASRDKTLRIWDL-- 200

  Fly   349 PSNMRNRSRSRQQV--DPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLRAKFSPM 411
                 |:...:.||  ....|.|..:..|            |.|::                  .
Human   201 -----NKHGKQIQVLSGHLQWVYCCSISP------------DCSML------------------C 230

  Fly   412 EQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHV 470
            ...|::.::         ::.:.:..:...:|||::.:...|:.||.:.:|:.|:||:|
Human   231 SAAGEKSVF---------LWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNV 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	57/314 (18%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	60/319 (19%)
		WD40 repeat	178..220	CDD:293791	12/56 (21%)
		WD40 repeat	225..260	CDD:293791	3/34 (9%)
		WD40 repeat	270..314	CDD:293791	8/43 (19%)
		WD40 repeat	323..395	CDD:293791	16/74 (22%)
		WD40 repeat	403..443	CDD:293791	1/39 (3%)
WSB2	NP_001265486.1	WD40 repeat	46..106	CDD:293791	15/64 (23%)
		WD40	47..384	CDD:225201	60/319 (19%)
		WD40	138..377	CDD:238121	40/205 (20%)
		WD40 repeat	174..212	CDD:293791	11/44 (25%)
		WD40 repeat	217..253	CDD:293791	5/74 (7%)
		WD40 repeat	261..306	CDD:293791	8/20 (40%)
		WD40 repeat	313..345	CDD:293791
		WD40 repeat	353..389	CDD:293791
		SOCS_WSB_SWIP	381..419	CDD:239702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900