DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9945 and AMBRA1

DIOPT Version :9

Sequence 1:NP_611494.1 Gene:CG9945 / 37329 FlyBaseID:FBgn0034527 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_001254711.1 Gene:AMBRA1 / 55626 HGNCID:25990 Length:1301 Species:Homo sapiens


Alignment Length:356 Identity:72/356 - (20%)
Similarity:122/356 - (34%) Gaps:107/356 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 EDDCQWIDVNG----LPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQILRTHRMPGK 267
            ||..:|:...|    ||....:.|.|.:||....:.....|..:.:|:::|            ||
Human    34 EDKTRWMKWEGKRVELPDSPRSTFLLAFSPDRTLLASTHVNHNIYITEVKT------------GK 86

  Fly   268 DVNSV--------CF-LHDKDPNVIIAGCDDGLLKVYDLRTTFRS--RDLSKSVASFIGHYDG-I 320
            .|:|:        |. .|.....:|.:||.||.::::||.....|  .|.:.::||...|... :
Human    87 CVHSLIGHRRTPWCVTFHPTISGLIASGCLDGEVRIWDLHGGSESWFTDSNNAIASLAFHPTAQL 151

  Fly   321 TYIDSRNDGYHVLSNSKDQSIKIWD--IRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHK 383
            ..|.:.|:            |..||  .|:|..:...:...::|....:|...:.:.....||..
Human   152 LLIATANE------------IHFWDWSRREPFAVVKTASEMERVRLVRFDPLGHYLLTAIVNPSN 204

  Fly   384 ---------PLEGDSSIMTYRGHRVTKTLLRAK--------------------------FSPMEQ 413
                     |::|     |...|...:.||:::                          |.|.||
Human   205 QQGDDEPEIPIDG-----TELSHYRQRALLQSQPVRRTPLLHNFLHMLSSRSSGIQTEPFHPPEQ 264

  Fly   414 TGQRYIYTG------------CATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDR--SEIVSG 464
            ........|            .:|....:.::..|..:.::.|      .|..||.|  .||..|
Human   265 ASSTQQDQGLLNRPSAFSTVQSSTAGNTLRNLSLGPTRRSLGG------PLSSHPSRYHREIAPG 323

  Fly   465 ----SWD-THVHLNNFSRSNANRPVKRSHSS 490
                .|. |.:.||:.|.:.:..|.:.|.||
Human   324 LTGSEWTRTVLSLNSRSEAESMPPPRTSASS 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9945NP_611494.1 WD40 128..467 CDD:295369 63/330 (19%)
WD40 repeat 131..170 CDD:293791
WD40 <133..478 CDD:225201 68/342 (20%)
WD40 repeat 178..220 CDD:293791 5/16 (31%)
WD40 repeat 225..260 CDD:293791 7/34 (21%)
WD40 repeat 270..314 CDD:293791 14/54 (26%)
WD40 repeat 323..395 CDD:293791 14/82 (17%)
WD40 repeat 403..443 CDD:293791 9/77 (12%)
AMBRA1NP_001254711.1 WD40 <48..>198 CDD:225201 36/173 (21%)
WD 1 51..90 10/50 (20%)
WD40 repeat 56..92 CDD:293791 11/47 (23%)
WD40 <59..198 CDD:295369 33/162 (20%)
WD 2 93..133 10/39 (26%)
WD40 repeat 99..135 CDD:293791 10/35 (29%)
WD 3 135..175 11/51 (22%)
WD40 repeat 140..176 CDD:293791 10/47 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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