DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9945 and WDR5B

DIOPT Version :9

Sequence 1:NP_611494.1 Gene:CG9945 / 37329 FlyBaseID:FBgn0034527 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_061942.2 Gene:WDR5B / 54554 HGNCID:17826 Length:330 Species:Homo sapiens


Alignment Length:310 Identity:70/310 - (22%)
Similarity:127/310 - (40%) Gaps:56/310 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 SIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSLRYSPTGDKIIGG 240
            ::....||||||..|.|:..|.:.|.....|:.:      ..|..|.|.|..:.:|....:::..
Human    43 AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE------KTLYGHNLEISDVAWSSDSSRLVSA 101

  Fly   241 SNNSTVIVTDIRTRNTQILRTHRMPGKDVNSVCFLHDKDPNVIIAGCDDGLLKVYDLRTTFRSRD 305
            |::.|:.:.|:  |:.:.|:|  :.|......|...:...|:||:|..|..:|:::::|      
Human   102 SDDKTLKLWDV--RSGKCLKT--LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT------ 156

  Fly   306 LSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRQPSNMR------NRSRSRQQVDP 364
             .|.:.:...|.|.::.:.....|..::|.|.|...:|||......::      |...|..:..|
Human   157 -GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSP 220

  Fly   365 T--------------TWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLRAKFSPMEQTG 415
            .              .|||...|                .:.||.||:..|..:.|.||   .||
Human   221 NGKYILTATLDNTLKLWDYSRGR----------------CLKTYTGHKNEKYCIFANFS---VTG 266

  Fly   416 QRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGS 465
            .::|.:|.....:.|:::.|.:|.:.::||..|:.....||..:.|.|.:
Human   267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9945NP_611494.1 WD40 128..467 CDD:295369 70/310 (23%)
WD40 repeat 131..170 CDD:293791
WD40 <133..478 CDD:225201 70/310 (23%)
WD40 repeat 178..220 CDD:293791 12/41 (29%)
WD40 repeat 225..260 CDD:293791 6/34 (18%)
WD40 repeat 270..314 CDD:293791 9/43 (21%)
WD40 repeat 323..395 CDD:293791 15/91 (16%)
WD40 repeat 403..443 CDD:293791 10/39 (26%)
WDR5BNP_061942.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
WD40 33..326 CDD:238121 70/310 (23%)
WD 1 39..78 11/40 (28%)
WD40 repeat 44..81 CDD:293791 12/42 (29%)
WD 2 81..122 10/44 (23%)
WD40 repeat 87..123 CDD:293791 7/39 (18%)
WD 3 124..164 9/46 (20%)
WD40 repeat 128..164 CDD:293791 9/42 (21%)
WD 4 165..204 9/38 (24%)
WD40 repeat 171..206 CDD:293791 7/34 (21%)
DDB1-binding motif 188..192 1/3 (33%)
WD 5 208..249 8/56 (14%)
WD40 repeat 213..249 CDD:293791 7/51 (14%)
WD 6 252..292 11/42 (26%)
WD40 repeat 257..294 CDD:293791 10/39 (26%)
WD 7 295..330 7/22 (32%)
WD40 repeat 300..326 CDD:293791 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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