DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9945 and dcaf11

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001005697.1	Gene:	dcaf11 / 448206	XenbaseID:	XB-GENE-946322	Length:	524	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	174/471 - (36%)
Similarity:	264/471 - (56%)	Gaps:	41/471 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IQMNSDEDDDFDSS-DNELGFNVINFTVNAMDLRSDYCSSEMPVIRGKPDLVKFQKTDMYKEIQA 70
            :|..||.|||.||: :..||...|                  |.:...||.....:..:..:...
Frog    69 VQSLSDSDDDNDSAWEGCLGDRYI------------------PPVDSAPDTTSLDQNQIRTQTLL 115

  Fly    71 SSGLVSNPNNRWNLVHALQQRENGLASPHSASFSKNQQRYISNLYIPNKK-ATRLMSLESKIFVT 134
            ::|..|. ..:.|:...|.:||..     ...|:..::..:::.::||.. ||.  |...|.|..
Frog   116 ATGRQST-QRQHNITRLLLERERA-----GCGFTMGERCRVTSHFLPNHVCATD--SYSQKAFCG 172

  Fly   135 KFNRSGSKLLTACQDGFVRIYDGAKGTYHLLNRIRARDVEWSIIDADFSPNGEHFAYSTWSRSLF 199
            .::.:||..::||||..:|:||...|.:.....::||||.||::|..|:|:|.||.||:||..:.
Frog   173 VYSPNGSVFMSACQDQNIRLYDCRNGAFKKFRTVKARDVGWSVLDVAFTPDGGHFLYSSWSDYIH 237

  Fly   200 IMPVNGGEDDCQWIDVNGLPS-HRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQILR--T 261
            |..:.|..:....:|::  || .|.|:|||..|..|.:|:||:|:..|.|.| |.:|.:.|:  :
Frog   238 ICNIYGDTESHTALDLS--PSERRFAVFSLTVSSDGREILGGANDRCVYVYD-REQNVRTLKIVS 299

  Fly   262 HRMPGKDVNSVCFLHDKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSR 326
            |.   .|||:|.|. |...:::.:|.||.|.||:| |.|.|..| .|.|....||.||||:|.|:
Frog   300 HE---DDVNAVSFA-DDSCHIVYSGGDDALCKVWD-RRTMREDD-PKPVGILAGHQDGITFIHSK 358

  Fly   327 NDGYHVLSNSKDQSIKIWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSI 391
            .|..::||||||||||:||||:.|.......||:.|....|||||.:||:.... .|.|.||:|:
Frog   359 GDARYLLSNSKDQSIKLWDIRRFSGPEGLEASRRAVTQQNWDYRWQQVPKRALR-KKRLPGDTSL 422

  Fly   392 MTYRGHRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHP 456
            ||||||.|..||:|.:|||...|||:::|:||:|||:::||:|||:|.:.:..|:..:||:.|||
Frog   423 MTYRGHGVLHTLIRCRFSPAYTTGQQFVYSGCSTGRVVVYDLLTGQIVKKLTNHKACVRDVSWHP 487

  Fly   457 DRSEIVSGSWDTHVHL 472
            ..:::||.|||.::.:
Frog   488 CENKLVSSSWDGNLRV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	146/341 (43%)
		WD40 repeat	131..170	CDD:293791	11/38 (29%)
		WD40	<133..478	CDD:225201	146/343 (43%)
		WD40 repeat	178..220	CDD:293791	13/41 (32%)
		WD40 repeat	225..260	CDD:293791	14/34 (41%)
		WD40 repeat	270..314	CDD:293791	17/43 (40%)
		WD40 repeat	323..395	CDD:293791	35/71 (49%)
		WD40 repeat	403..443	CDD:293791	20/39 (51%)
dcaf11	NP_001005697.1	WD40 repeat	173..208	CDD:293791	10/34 (29%)
		WD40	214..505	CDD:392136	131/300 (44%)
		WD40 repeat	215..257	CDD:293791	14/43 (33%)
		WD40 repeat	263..299	CDD:293791	15/36 (42%)
		WD40 repeat	304..346	CDD:293791	18/44 (41%)
		WD40 repeat	380..426	CDD:293791	18/46 (39%)
		WD40 repeat	434..464	CDD:293791	15/29 (52%)
		WD40 repeat	480..504	CDD:293791	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6742
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11886
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2787
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1219799at2759
OrthoFinder	1	1.000	-	-		FOG0006573
OrthoInspector	1	1.000	-	-		oto103589
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3057
SonicParanoid	1	1.000	-	-		X4812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090