DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and nup37

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001002619.1	Gene:	nup37 / 436892	ZFINID:	ZDB-GENE-040718-363	Length:	326	Species:	Danio rerio

Alignment Length:	388	Identity:	77/388 - (19%)
Similarity:	118/388 - (30%)	Gaps:	140/388 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 KKATRLMSLESKIFVTKFN----RSGSKLLTACQDGFVRIYDGAK----GTYH------------ 163
            :.||..:..|..:.|.:|:    .|.:.||.         |.|.|    ||..
Zfish     7 RSATYTVPCEDYVHVVEFSPYDCGSPASLLA---------YGGNKYVVVGTCRFKEEDAEVEGVE 62

  Fly   164 ------LLNRIRARDVEWS----------IIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQW 212
                  .::.:|...:.||          :|  .||..........|:..|        ::.|
Zfish    63 FNSLQVFMHGVRVDAIAWSPETHLDKLPPVI--RFSTAAADRKIRLWTSDL--------QNSC-- 115

  Fly   213 IDVNGLPSHRLAIFSLRYSPT-GDKIIGGSNNSTVIVTDIRTRNTQILRTHRMPGKDVNSVCFLH 276
             ||..:..|...|..|.:.|. |.:|...|::.|..|.|:....|...|. |.||.   |||: |
Zfish   116 -DVKVMEGHTSYINHLVFEPAEGKQIASVSDDHTCRVWDLDGNETTSFRL-RSPGV---SVCW-H 174

  Fly   277 DKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVLSNSKD--- 338
            .:|...::.....|.::.|||.|......|                     |...|...|.|
Zfish   175 PEDNCKLMVAEKKGTIRFYDLVTQHAILSL---------------------DSGQVPLMSADWCL 218

  Fly   339 -QSIK----------IWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSIM 392
             .:||          ||||.:.|....:..:  .||... .:||:|.....:
Zfish   219 TNTIKVGAVVANDWVIWDITRSSYPLEKRPA--HVDKAR-HFRWSRANENLF------------- 267

  Fly   393 TYRGHRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWH 455
                               ..||    |.|....:::::.:  |..|..:.|..:|...|.||
Zfish   268 -------------------ATTG----YPGKINSQLLVHHL--GHPQPVMLGSASVGAGLSWH 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	75/379 (20%)
		WD40 repeat	131..170	CDD:293791	10/64 (16%)
		WD40	<133..478	CDD:225201	74/374 (20%)
		WD40 repeat	178..220	CDD:293791	8/41 (20%)
		WD40 repeat	225..260	CDD:293791	10/35 (29%)
		WD40 repeat	270..314	CDD:293791	11/43 (26%)
		WD40 repeat	323..395	CDD:293791	16/85 (19%)
		WD40 repeat	403..443	CDD:293791	6/39 (15%)
nup37	NP_001002619.1	WD40 repeat	20..59	CDD:293791	10/47 (21%)
		WD40	30..237	CDD:295369	53/254 (21%)
		WD40	<71..>277	CDD:225201	57/283 (20%)
		WD40 repeat	77..122	CDD:293791	10/57 (18%)
		WD40 repeat	128..164	CDD:293791	9/35 (26%)
		WD40 repeat	168..205	CDD:293791	12/61 (20%)
		WD40 repeat	212..241	CDD:293791	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900