DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and Wdr5

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001034123.1	Gene:	Wdr5 / 362093	RGDID:	1305159	Length:	334	Species:	Rattus norvegicus

Alignment Length:	310	Identity:	66/310 - (21%)
Similarity:	129/310 - (41%)	Gaps:	56/310 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 SIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSLRYSPTGDKIIGG 240
            ::....||||||..|.|:..:.:.|.....|:.:      ..:..|:|.|..:.:|...:.::..
  Rat    47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE------KTISGHKLGISDVAWSSDSNLLVSA 105

  Fly   241 SNNSTVIVTDIRTRNTQILRTHRMPGKDVNSVCFLHDKDPNVIIAGCDDGLLKVYDLRTTFRSRD 305
            |::.|:.:.|:  .:.:.|:|  :.|......|...:...|:|::|..|..::::|::|
  Rat   106 SDDKTLKIWDV--SSGKCLKT--LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT------ 160

  Fly   306 LSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRQPSNMR------NRSRSRQQVDP 364
             .|.:.:...|.|.::.:....||..::|:|.|...:|||......::      |...|..:..|
  Rat   161 -GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSP 224

  Fly   365 T--------------TWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLRAKFSPMEQTG 415
            .              .|||...:                .:.||.||:..|..:.|.||   .||
  Rat   225 NGKYILAATLDNTLKLWDYSKGK----------------CLKTYTGHKNEKYCIFANFS---VTG 270

  Fly   416 QRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGS 465
            .::|.:|.....:.|:::.|.:|.:.::||..|:.....||..:.|.|.:
  Rat   271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAA 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	66/310 (21%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	66/310 (21%)
		WD40 repeat	178..220	CDD:293791	10/41 (24%)
		WD40 repeat	225..260	CDD:293791	5/34 (15%)
		WD40 repeat	270..314	CDD:293791	8/43 (19%)
		WD40 repeat	323..395	CDD:293791	15/91 (16%)
		WD40 repeat	403..443	CDD:293791	10/39 (26%)
Wdr5	NP_001034123.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		WD40	37..331	CDD:238121	66/310 (21%)
		WD 1	43..82		10/40 (25%)
		WD40 repeat	48..85	CDD:293791	10/42 (24%)
		WD 2	85..126		9/44 (20%)
		WD40 repeat	91..127	CDD:293791	6/39 (15%)
		WD 3	128..168		8/46 (17%)
		WD40 repeat	132..168	CDD:293791	8/42 (19%)
		WD 4	169..208		10/38 (26%)
		WD40 repeat	175..210	CDD:293791	8/34 (24%)
		WD 5	212..253		7/56 (13%)
		WD40 repeat	217..253	CDD:293791	6/51 (12%)
		WD 6	256..296		11/42 (26%)
		WD40 repeat	261..298	CDD:293791	10/39 (26%)
		WD 7	299..333		7/22 (32%)
		WD40 repeat	304..330	CDD:293791	4/17 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810