DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and wsb1

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_955927.1	Gene:	wsb1 / 323226	ZFINID:	ZDB-GENE-030131-1946	Length:	423	Species:	Danio rerio

Alignment Length:	328	Identity:	65/328 - (19%)
Similarity:	120/328 - (36%)	Gaps:	116/328 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSL----------- 228
            |::.   |:|:|.:||:|...|.:.::|         |       ...||.||:
Zfish    38 WTVA---FAPDGSYFAWSQGHRIVRLVP---------W-------KKCLASFSVRKEDRSSGAGP 83

  Fly   229 ----RYSPTGDKIIGGSNNSTVIVTDI-------------RTRNTQILRTHRMPGKDVNSVCFLH 276
                |.:..|..:.|.....|:...||             ::|...| ..||          |..
Zfish    84 RRLSRQNSEGSLLPGEPREHTIDCGDIVWGLAFGSSVPEKQSRCVNI-EWHR----------FKF 137

  Fly   277 DKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVL-SNSKDQS 340
            .:|..::..|.::|.:|::|:.|       .|.:.:.:.|.|.:..:....||..|| |.|:|::
Zfish   138 GQDQLLLATGLNNGRIKIWDVYT-------GKLLLNLMDHTDIVRDLTFAPDGSLVLVSASRDKT 195

  Fly   341 IKIWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLR 405
            :::||::...||....|..|     .|.|      ...::|      |||::
Zfish   196 LRVWDLKDDGNMVKVLRGHQ-----NWVY------CSAFSP------DSSVL------------- 230

  Fly   406 AKFSPMEQTGQRYIYTGCATG---RIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWD 467
                             |:.|   .:.::|:....:...:|||...:...::.||.:.:.:.|:|
Zfish   231 -----------------CSVGAGKAVFLWDMDKYTLIRKLEGHHNDVVCCEFSPDGALLATASYD 278

  Fly   468 THV 470
            |.|
Zfish   279 TRV 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	62/323 (19%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	65/328 (20%)
		WD40 repeat	178..220	CDD:293791	9/41 (22%)
		WD40 repeat	225..260	CDD:293791	10/62 (16%)
		WD40 repeat	270..314	CDD:293791	8/43 (19%)
		WD40 repeat	323..395	CDD:293791	19/72 (26%)
		WD40 repeat	403..443	CDD:293791	3/42 (7%)
wsb1	NP_955927.1	WD40	38..379	CDD:225201	65/328 (20%)
		WD40 repeat	38..71	CDD:293791	12/51 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..100		3/23 (13%)
		WD 1	125..166		12/58 (21%)
		WD40 repeat	135..169	CDD:293791	8/40 (20%)
		WD40	136..379	CDD:238121	40/200 (20%)
		WD 2	169..209		13/39 (33%)
		WD40 repeat	175..213	CDD:293791	11/37 (30%)
		WD 3	213..252		10/85 (12%)
		WD40 repeat	218..254	CDD:293791	8/77 (10%)
		WD 4	255..294		8/27 (30%)
		WD40 repeat	261..296	CDD:293791	6/21 (29%)
		WD 5	310..347
		WD40 repeat	315..353	CDD:293791
		SOCS_WSB1_SWIP1	383..422	CDD:239715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900