DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9945 and Nwd1

DIOPT Version :9

Sequence 1:NP_611494.1 Gene:CG9945 / 37329 FlyBaseID:FBgn0034527 Length:511 Species:Drosophila melanogaster
Sequence 2:XP_006531149.1 Gene:Nwd1 / 319555 MGIID:2442268 Length:1573 Species:Mus musculus


Alignment Length:524 Identity:91/524 - (17%)
Similarity:156/524 - (29%) Gaps:178/524 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 SSEMPVIRGKPDL--VKFQKTDMYKEIQASSGLVSNPNNRWNLVHALQQRENGLASPHSASFSKN 106
            ||.|..::.|..|  :|.:.......||:.:.||:                 |.:|...|..|..
Mouse  1038 SSAMGKLQEKHQLSSIKEETPTCAVSIQSRARLVA-----------------GFSSGSIALVSAG 1085

  Fly   107 QQRYISNLYIPNKKATRLMSLESKIFVTKFNRSGSKLLTACQDGFVRIYDGAKGTYHLLNRIRAR 171
            :.|.:..|  |......::|.:..:.|..|.|            ||||:......:|   |..|.
Mouse  1086 EDRLLEKL--PEAVGFLVVSEDDSLLVAGFGR------------FVRIFLADSQGFH---RFMAS 1133

  Fly   172 DVEWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSLRYSPTGDK 236
            |:|                                              |...:.:....|..:.
Mouse  1134 DLE----------------------------------------------HEDMVETAVLGPENNL 1152

  Fly   237 IIGGSNNSTVIVTDIRTRNT--QILRTHRMPGKDVNSVCFLHDKDPNVIIAGCDDGLLKVYDLRT 299
            ||.||.::.:.|..:..:.|  .:|.....|      |..|......|:.|.......||:||::
Mouse  1153 IITGSRDALIQVWSLSEQGTLLNVLEGVGAP------VSLLVRGGTLVVSASRKSSSFKVWDLKS 1211

  Fly   300 TFRSRD----LSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRQ------------ 348
            |.:.:.    |.::..:.:.|:....|.....|         ...:.|||:.:            
Mouse  1212 TKKLQSPTPFLDRTGLAAVSHHGSFVYFPKVGD---------KNKVTIWDLAEGEEQDCLDTSNE 1267

  Fly   349 -------------------------PSNMRN------RSRSRQQVDPTTWDYRWNRVPREFYN-- 380
                                     |.|.|.      ...:|:.|:..:.....||:...:.|  
Mouse  1268 VRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARKAVNCMSLSKSENRLAIAYDNIV 1332

  Fly   381 ---------PHKPLEGDS-SIMTYRGHRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLT 435
                     |...:||.: :..|.....:....:.|.:        |.:| |.:.|.:.:||...
Mouse  1333 LVLDISPGDPCPAIEGPTYTFYTQLPETIVSVAVLADY--------RVVY-GMSDGSLFLYDCAC 1388

  Fly   436 GKIQEAIEGHRTVIRDLDWHPDRSEIVSGS-------WDTHVHLNNFSRSNAN---RPVKRSHSS 490
            .|: ..:|.|.:.:..::........|||:       ||.......|..|..|   |.|:.:..|
Mouse  1389 SKV-FPLEAHGSRVSCVEVSHSEQLAVSGAEDALLCLWDLQACRGMFEMSYENSCCRGVRCACFS 1452

  Fly   491 DHDK 494
            ..||
Mouse  1453 RDDK 1456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9945NP_611494.1 WD40 128..467 CDD:295369 63/406 (16%)
WD40 repeat 131..170 CDD:293791 9/38 (24%)
WD40 <133..478 CDD:225201 66/412 (16%)
WD40 repeat 178..220 CDD:293791 0/41 (0%)
WD40 repeat 225..260 CDD:293791 7/36 (19%)
WD40 repeat 270..314 CDD:293791 10/47 (21%)
WD40 repeat 323..395 CDD:293791 16/126 (13%)
WD40 repeat 403..443 CDD:293791 8/39 (21%)
Nwd1XP_006531149.1 AAA 315..>361 CDD:99707
P-loop_NTPase 337..504 CDD:393355
WD40 870..1166 CDD:392136 37/207 (18%)
WD40 repeat 881..918 CDD:293791
WD40 repeat 924..961 CDD:293791
WD40 repeat 966..1006 CDD:293791
WD40 repeat 1014..1051 CDD:293791 4/12 (33%)
WD40 1038..1471 CDD:225201 91/524 (17%)
WD40 repeat 1097..1134 CDD:293791 11/51 (22%)
WD40 repeat 1141..1165 CDD:293791 5/23 (22%)
WD40 repeat 1183..1216 CDD:293791 10/38 (26%)
WD40 repeat 1269..1307 CDD:293791 3/37 (8%)
WD40 repeat 1312..1347 CDD:293791 5/34 (15%)
WD40 repeat 1362..1393 CDD:293791 8/40 (20%)
WD40 repeat 1401..1439 CDD:293791 7/37 (19%)
WD40 repeat 1446..1483 CDD:293791 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0266
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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