DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and Wdr5b

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001019937.1	Gene:	Wdr5b / 303907	RGDID:	1308567	Length:	328	Species:	Rattus norvegicus

Alignment Length:	336	Identity:	77/336 - (22%)
Similarity:	140/336 - (41%)	Gaps:	64/336 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 RIYDGAKGTYHLLNRIRARDVEWSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNG 217
            |:.:..|..|.|  |:.......:|....||||||..|.|.....:.|.....|:  |:    ..
  Rat    20 RVEEPQKPNYAL--RLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGK--CK----KT 76

  Fly   218 LPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRT-RNTQILRTHRMPGKDVNSVCFLHDKDP- 280
            |..|.|.|..:.:|....:::..|::.|:.:.|:|: :..:.|:.|       :...|..|.:|
  Rat    77 LYGHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGH-------SDFVFCCDFNPP 134

  Fly   281 -NVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIW 344
             |:|::|..|..:|:::::|       .|.:.:...|.|.|:.:....:|..::|.|.|...:||
  Rat   135 SNLIVSGSFDESVKIWEVKT-------GKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIW 192

  Fly   345 D------IRQPSNMRNRSRSRQQVDPT--------------TWDYRWNRVPREFYNPHKPLEGDS 389
            |      :|..::..|...|..:..|.              .|||...|
  Rat   193 DAASGQCLRTLADEGNPPVSFVKFSPNGKYILTATLDSTLKLWDYSRGR---------------- 241

  Fly   390 SIMTYRGHRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDW 454
            .:.||.||:..|..:.|.||   .||::::.:|.....:.|:::.|.:|.:.::||..|:.....
  Rat   242 CLKTYTGHKNEKYCIFASFS---VTGRKWVVSGSEDNMVYIWNLQTKEIVQRLQGHTDVVISAAC 303

  Fly   455 HPDRSEIVSGS 465
            ||..:.|.|.:
  Rat   304 HPTENIIASAA 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	77/336 (23%)
		WD40 repeat	131..170	CDD:293791	5/16 (31%)
		WD40	<133..478	CDD:225201	77/336 (23%)
		WD40 repeat	178..220	CDD:293791	12/41 (29%)
		WD40 repeat	225..260	CDD:293791	6/35 (17%)
		WD40 repeat	270..314	CDD:293791	10/45 (22%)
		WD40 repeat	323..395	CDD:293791	16/91 (18%)
		WD40 repeat	403..443	CDD:293791	9/39 (23%)
Wdr5b	NP_001019937.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		1/2 (50%)
		WD40	31..325	CDD:238121	74/325 (23%)
		WD40	<34..325	CDD:225201	72/320 (23%)
		WD 1	37..76		12/44 (27%)
		WD40 repeat	42..79	CDD:293791	13/42 (31%)
		WD 2	79..120		8/40 (20%)
		WD40 repeat	85..121	CDD:293791	6/35 (17%)
		WD 3	122..162		11/53 (21%)
		WD40 repeat	126..162	CDD:293791	10/42 (24%)
		WD 4	163..202		10/38 (26%)
		WD40 repeat	169..204	CDD:293791	8/34 (24%)
		DDB1-binding motif	186..190		1/3 (33%)
		WD 5	206..247		8/56 (14%)
		WD40 repeat	211..247	CDD:293791	7/51 (14%)
		WD 6	250..290		10/42 (24%)
		WD40 repeat	255..292	CDD:293791	9/39 (23%)
		WD 7	293..328		7/22 (32%)
		WD40 repeat	298..324	CDD:293791	4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810