DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and Wsb2

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_008767442.1	Gene:	Wsb2 / 288692	RGDID:	1359599	Length:	406	Species:	Rattus norvegicus

Alignment Length:	360	Identity:	74/360 - (20%)
Similarity:	128/360 - (35%)	Gaps:	139/360 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WSIIDADFSPNGEHFAYS---------TWSRSLFIMPVNGGED--------------------DC 210
            ||:.   |||:|..||:|         .|......:| .|.|.                    ||
  Rat    32 WSVA---FSPDGSWFAWSQGHCVVKLVPWPLEEQFIP-KGFEAKSRSSKNDSKGRGSLKEKTLDC 92

  Fly   211 QWIDVNGLPSHRLAIFSLRYSPTGDKIIGGSNNSTVIVTDIRTRNTQILRTH-RMPGKDVNSVCF 274
            ..| |.||      .||...||...|:                    .||.| ::|  ||:.:
  Rat    93 GQI-VWGL------AFSPWPSPPSRKL--------------------WLRHHPQVP--DVSCL-- 126

  Fly   275 LHDKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVL-SNSKD 338
                   ::..|.:||.:|:::::|.....:||       ||.|.:..:....:|..:| |.|:|
  Rat   127 -------ILATGLNDGQIKIWEVQTGLLLLNLS-------GHQDVVRDLSFTPNGSLILVSASRD 177

  Fly   339 QSIKIWDIRQPSNMRNRSRSRQQV--DPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTK 401
            ::::|||:       |:...:.||  ....|.|..:..|            |.|::
  Rat   178 KTLRIWDL-------NKHGKQIQVLSGHLQWVYCCSISP------------DCSML--------- 214

  Fly   402 TLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSW 466
                     ....|::.::         ::.:.:..:...:|||::.:...|:.||.:.:|:.|:
  Rat   215 ---------CSAAGEKSVF---------LWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASY 261

  Fly   467 DTHV---------HLNNFSRSNANRPVKRS--HSS 490
            ||.|         .|.:...:....||..|  |.|
  Rat   262 DTSVIMWDPYTGERLRSLHHTQLEAPVDDSDVHMS 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	65/324 (20%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	69/344 (20%)
		WD40 repeat	178..220	CDD:293791	17/70 (24%)
		WD40 repeat	225..260	CDD:293791	5/34 (15%)
		WD40 repeat	270..314	CDD:293791	7/43 (16%)
		WD40 repeat	323..395	CDD:293791	16/74 (22%)
		WD40 repeat	403..443	CDD:293791	1/39 (3%)
Wsb2	XP_008767442.1	WD40 repeat	31..91	CDD:293791	13/62 (21%)
		WD40	32..369	CDD:225201	74/360 (21%)
		WD40	123..362	CDD:238121	45/236 (19%)
		WD40 repeat	159..197	CDD:293791	11/44 (25%)
		WD40 repeat	202..238	CDD:293791	5/74 (7%)
		WD40 repeat	246..291	CDD:293791	11/44 (25%)
		WD40 repeat	298..330	CDD:293791
		WD40 repeat	338..374	CDD:293791
		SOCS_WSB_SWIP	366..404	CDD:239702
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900