DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and WSB1

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_056441.6	Gene:	WSB1 / 26118	HGNCID:	19221	Length:	421	Species:	Homo sapiens

Alignment Length:	366	Identity:	73/366 - (19%)
Similarity:	134/366 - (36%)	Gaps:	128/366 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 WSIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSLRYSPTGDKIIG 239
            |::.   |:|:|.:||:|...|::.::|         |       |..|..|.|.    |.|.:
Human    38 WTVA---FAPDGSYFAWSQGHRTVKLVP---------W-------SQCLQNFLLH----GTKNV- 78

  Fly   240 GSNNSTVIV----TDIRTRNTQILRTHRMPGKDV-------------NSVC-------FLHDKDP 280
             :|:|::.:    :|...:|..  |.|.:...|:             .|.|       |...:|.
Human    79 -TNSSSLRLPRQNSDGGQKNKP--REHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQ 140

  Fly   281 NVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVL-SNSKDQSIKIW 344
            .::..|.::|.:|::|:.|       .|.:.:.:.|.:.:..:....||..:| |.|:|:::::|
Human   141 LLLATGLNNGRIKIWDVYT-------GKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVW 198

  Fly   345 DIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLRAKFS 409
            |::...||....|..|     .|.|.....|            |||::
Human   199 DLKDDGNMMKVLRGHQ-----NWVYSCAFSP------------DSSML----------------- 229

  Fly   410 PMEQTGQRYIYTGCATG---RIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVH 471
                         |:.|   .:.::::....:...:|||...:...|:.||.:.:.:.|:||.|:
Human   230 -------------CSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDTRVY 281

  Fly   472 ---------LNNFSR----------SNANRPVKRSHSSDHD 493
                     |..|..          ..||....||.|..||
Human   282 IWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHD 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	61/319 (19%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	66/349 (19%)
		WD40 repeat	178..220	CDD:293791	9/41 (22%)
		WD40 repeat	225..260	CDD:293791	8/38 (21%)
		WD40 repeat	270..314	CDD:293791	10/50 (20%)
		WD40 repeat	323..395	CDD:293791	18/72 (25%)
		WD40 repeat	403..443	CDD:293791	2/42 (5%)
WSB1	NP_056441.6	WD 1	32..71		12/51 (24%)
		WD40	38..382	CDD:225201	73/366 (20%)
		WD40 repeat	59..105	CDD:293791	14/69 (20%)
		WD 2	124..165		10/47 (21%)
		WD40	135..388	CDD:238121	47/242 (19%)
		WD 3	168..208		11/39 (28%)
		WD40 repeat	174..212	CDD:293791	10/37 (27%)
		WD 4	212..251		9/85 (11%)
		WD40 repeat	217..253	CDD:293791	7/77 (9%)
		WD 5	254..293		10/38 (26%)
		WD40 repeat	261..299	CDD:293791	9/37 (24%)
		WD 6	309..346		7/14 (50%)
		WD40 repeat	314..353	CDD:293791	5/9 (56%)
		SOCS_WSB1_SWIP1	382..421	CDD:239715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900