DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and Dcaf10

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_694807.2	Gene:	Dcaf10 / 242418	MGIID:	2140179	Length:	566	Species:	Mus musculus

Alignment Length:	307	Identity:	67/307 - (21%)
Similarity:	121/307 - (39%)	Gaps:	93/307 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 AIFSLRYSPTGDKIIGGSNNSTVIVTD-IRTRNTQIL-RTHRMPGKD-VNSVCFLHDKDPNVIIA 285
            |:|:|.|||.|..:......:.|::.| |.:::.:.| ..|    :| ||::.||    .|.:.|
Mouse   177 AVFNLEYSPDGSVLTVACEQTEVLLFDPISSKHIKTLSEAH----EDCVNNIRFL----DNRLFA 233

  Fly   286 GC-DDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGITYIDSRNDGYHVLSNSKDQSIKIWDIRQP 349
            .| ||..:.::||      |.|:..|.:..||...:..|:...:...::::..|.::.|||.
Mouse   234 TCSDDTTIALWDL------RKLNTKVCTLHGHTSWVKNIEYDTNTRLLVTSGFDGNVIIWDT--- 289

  Fly   350 SNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRGHRVTKTLLRAKFSP---- 410
                                  ||...:.. |||..          .|  |:.|:|.:.:|
Mouse   290 ----------------------NRCTEDGC-PHKKF----------FH--TRFLMRMRLTPDCSK 319

  Fly   411 -MEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEIVSGSWDTHVHLNN 474
             :..|...|:        :|::::...|..|.  |...::        |:...:.|.|    |..
Mouse   320 MLISTSSGYL--------LILHELDLTKSLEV--GSYPIL--------RARRTTSSSD----LTT 362

  Fly   475 FSRSNANR----PVKRSHSSDHDKKPLRRSRR--LANRN----VTPD 511
            .|.|:.:|    |...:.|:..:|...|.|:|  ::.||    :||:
Mouse   363 TSSSSGSRVSGSPCHHNDSNSTEKHMSRASQREGVSPRNSLEVLTPE 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	52/251 (21%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	55/262 (21%)
		WD40 repeat	178..220	CDD:293791
		WD40 repeat	225..260	CDD:293791	10/36 (28%)
		WD40 repeat	270..314	CDD:293791	13/44 (30%)
		WD40 repeat	323..395	CDD:293791	10/71 (14%)
		WD40 repeat	403..443	CDD:293791	8/44 (18%)
Dcaf10	NP_694807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..123
		WD40	<171..326	CDD:295369	45/200 (23%)
		WD 1	173..212		10/34 (29%)
		WD40	<178..>326	CDD:225201	44/199 (22%)
		WD40 repeat	179..214	CDD:293791	9/34 (26%)
		WD 2	216..254		15/51 (29%)
		WD40 repeat	221..257	CDD:293791	14/45 (31%)
		WD 3	258..297		9/63 (14%)
		WD40 repeat	263..289	CDD:293791	4/25 (16%)
		WD 4	303..342		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..413		16/60 (27%)
		WD 5	415..455
		WD 6	477..515
		WD40	524..562	CDD:197651
		WD 7	533..566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900