DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9945 and wdr-5.1

DIOPT Version :9

Sequence 1:	NP_611494.1	Gene:	CG9945 / 37329	FlyBaseID:	FBgn0034527	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_497749.1	Gene:	wdr-5.1 / 175474	WormBaseID:	WBGene00006474	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	338	Identity:	72/338 - (21%)
Similarity:	140/338 - (41%)	Gaps:	96/338 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 SIIDADFSPNGEHFAYSTWSRSLFIMPVNGGEDDCQWIDVNGLPSHRLAIFSLRYSPTGDKIIGG 240
            ||..|.|||.|::...|:..:::.|..::      ..|....|..|:|.:..:.:|.....::..
Worm    89 SISSAKFSPCGKYLGTSSADKTVKIWNMD------HMICERTLTGHKLGVNDIAWSSDSRCVVSA 147

  Fly   241 SNNSTVIVTDIRT-RNTQILRTHRMPGKDVNSVCFLHDKDP--NVIIAGCDDGLLKVYDLRT--- 299
            |::.|:.:.:|.| |.|:.|:.|       |:..|..:.:|  :::::|..|..::::|::|
Worm   148 SDDKTLKIFEIVTSRMTKTLKGH-------NNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMC 205

  Fly   300 --TFRSRDLSKSVASF--------IGHYDGI-------------TYIDSRN----------DGYH 331
              |..:.....|..||        .|.|||:             |.:|..|          :|.:
Worm   206 IKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDDENPPVAFVKFSPNGKY 270

  Fly   332 VLSNSKDQSIKIWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPLEGDSSIMTYRG 396
            :|:::.|.::|:||..:...::.                                       |.|
Worm   271 ILASNLDSTLKLWDFSKGKTLKQ---------------------------------------YTG 296

  Fly   397 HRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIRDLDWHPDRSEI 461
            |..:|..:.|.||   .||.::|.:|....:|.|:::.|.:|.:.:|||...:...|.||.::.|
Worm   297 HENSKYCIFANFS---VTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPVLASDCHPVQNII 358

  Fly   462 VSGSW--DTHVHL 472
            .||:.  |..:|:
Worm   359 ASGALEPDNKIHI 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:295369	70/331 (21%)
		WD40 repeat	131..170	CDD:293791
		WD40	<133..478	CDD:225201	72/338 (21%)
		WD40 repeat	178..220	CDD:293791	9/41 (22%)
		WD40 repeat	225..260	CDD:293791	7/35 (20%)
		WD40 repeat	270..314	CDD:293791	11/58 (19%)
		WD40 repeat	323..395	CDD:293791	8/81 (10%)
		WD40 repeat	403..443	CDD:293791	11/39 (28%)
wdr-5.1	NP_497749.1	WD40	<76..372	CDD:225201	72/338 (21%)
		WD40	79..373	CDD:238121	72/338 (21%)
		WD40 repeat	90..127	CDD:293791	10/42 (24%)
		WD40 repeat	133..169	CDD:293791	8/35 (23%)
		WD40 repeat	174..210	CDD:293791	7/35 (20%)
		WD40 repeat	217..252	CDD:293791	8/34 (24%)
		WD40 repeat	259..295	CDD:293791	6/74 (8%)
		WD40 repeat	303..340	CDD:293791	11/39 (28%)
		WD40 repeat	346..372	CDD:293791	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810