Protein Alignment CG9945 and wdr-23

DIOPT Version :10

• Sequence 1: NP_611494.1
• Gene: CG9945 / 37329
• FlyBaseID: FBgn0034527
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_492124.1
• Gene: wdr-23 / 172518
• WormBaseID: WBGene00008419
• Length: 571
• Species: Caenorhabditis elegans
• Alignment Length: 530
• Identity: 179/530 - (33%)
• Similarity: 279/530 - (52%)
• Gaps: 69/530 - (13%)

  Fly    10 NSDEDDDFDSSDNELGFNVINFTVNAMDLRSDYCSSEMPVIRGKPDLVKFQKTDMYKEIQASSGL 74
            ::|.|.|| |||:|....:.......|..|..:.:.......|.|:    ..|.:..||.:..|.
 Worm    57 SNDSDTDF-SSDDEGCPKMTPHEEQQMFEREQHIAFSGRCHIGDPE----SCTQLRNEINSRCGP 116

  Fly    75 VSNPNNRWNLV--HALQQRENGLASPHSASFSKNQQRYISNLYIPNKKATRLMSLESKIFVTKFN 137
            ..:.:|....:  ..||:|...:::|.:.:       .:.|.::||:| .|:..:.:|.|.|::.
 Worm   117 RPSTSNNMEFILNRDLQKRGTSISNPRTVA-------RVLNSHLPNQK-RRVDRVATKSFCTQYI 173

  Fly   138 RSGSKLLTACQDGFVRIY----DGAK--GTYHLLNRIRARDVEWSIIDADFSPNGEHFAYSTWSR 196
            ::|:|::.|.||..:|.|    |.:|  ..|...:.:|.....|||:|...|.||:..||.||..
 Worm   174 QNGTKIVVASQDEKIRFYQRNPDKSKYRSKYMKSDELRVDQCGWSILDTAISLNGDLIAYGTWKD 238

  Fly   197 SLFIMPVNGGE-DDCQW--IDVNGLPSH-RLAIFSLRYSPTGDKIIGGSNNSTVIVTDI--RTRN 255
            ::|:..::..| .:..|  ||:||.|.. ..|:|.:::|.:.::|:.|::..::.|.|:  |.|.
 Worm   239 AVFVGKLDFTERQNITWFPIDLNGEPGRDHCAVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRI 303

  Fly   256 TQILRTHRMPGKDVNSVCFLHDKDPNVIIAGCDDGLLKVYDLRTTFRSRDLSKSVASFIGHYDGI 320
            ..|:..|.   .|||||||. |...|:|.:..||||:||:|.| .:...|: :.|..|.||.||:
 Worm   304 RTIVNAHE---DDVNSVCFA-DLGSNLIYSAGDDGLVKVWDKR-AWSDGDV-EPVGVFAGHRDGV 362

  Fly   321 TYIDSRNDGYHVLSNSKDQSIKIWDIRQPSNMRNRSRSRQQVDPTTWDYRWNRVPREFYNPHKPL 385
            |::|||.|..::|||||||:||:||:|:.|||.....:|..|....|||||...|....   :|:
 Worm   363 THVDSRQDERYLLSNSKDQTIKVWDLRKFSNMSGVEATRACVQSQHWDYRWQPAPPGLC---QPV 424

  Fly   386 EGDSSIMTYRGHRVTKTLLRAKFSPMEQTGQRYIYTGCATGRIIIYDVLTGKIQEAIEGHRTVIR 450
            .||:|:||.|||.|..||:||.||| |.||:||||||||.|.:::||:::|.:...::||..|:|
 Worm   425 AGDTSVMTLRGHSVLHTLVRANFSP-ESTGRRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVR 488

  Fly   451 DLDWHPDRSEIVSGSWD-------------------THVHLNNF----SRSNANRPVKRSHSSDH 492
            :.||||..:||||.:||                   .|.:::.|    |.....:||
 Worm   489 ECDWHPTENEIVSSAWDGVTTVWTWDERQEGVIAPYDHPNISQFGDEDSCDELFQPV-------- 545

  Fly   493 DKKPLRRSRR 502
             ||..||.|:
 Worm   546 -KKQCRRQRK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9945	NP_611494.1	WD40	128..467	CDD:475233	141/350 (40%)
		WD40 repeat	131..170	CDD:293791	12/44 (27%)
		WD40 repeat	178..220	CDD:293791	15/44 (34%)
		WD40 repeat	225..260	CDD:293791	9/36 (25%)
		WD40 repeat	270..314	CDD:293791	18/43 (42%)
		WD40 repeat	323..395	CDD:293791	33/71 (46%)
		WD40 repeat	403..443	CDD:293791	21/39 (54%)
wdr-23	NP_492124.1	WD40 repeat	167..205	CDD:293791	11/37 (30%)
		WD40	<175..514	CDD:441893	140/348 (40%)
		WD40 repeat	220..269	CDD:293791	16/48 (33%)
		WD40 repeat	271..307	CDD:293791	8/35 (23%)
		WD40 repeat	315..356	CDD:293791	18/43 (42%)
		WD40 repeat	362..434	CDD:293791	34/74 (46%)
		WD40 repeat	442..481	CDD:293791	21/39 (54%)
		WD40 repeat	487..511	CDD:293791	11/23 (48%)