DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hil and MICAL2

DIOPT Version :9

Sequence 1:NP_611493.2 Gene:Hil / 37328 FlyBaseID:FBgn0050147 Length:818 Species:Drosophila melanogaster
Sequence 2:NP_001380866.1 Gene:MICAL2 / 9645 HGNCID:24693 Length:1957 Species:Homo sapiens


Alignment Length:286 Identity:61/286 - (21%)
Similarity:85/286 - (29%) Gaps:109/286 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 TCLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHV---- 70
            ||..|.:.||.::|:.  .:..|||..||:|..|.|.|.|..|   ....|:.:.||..|.    
Human  1001 TCYFCKKRVYVMERLS--AEGHFFHRECFRCSICATTLRLAAY---TFDCDEGKFYCKPHFIHCK 1060

  Fly    71 ----PKSGPGHLDQ--TSVGIRQALNAPRTNKFVNEQIRGTRSE----------VDGGP------ 113
                .:.....|.|  ......|...|||         |.|.:|          ::|.|      
Human  1061 TNSKQRKRRAELKQQREEEATWQEQEAPR---------RDTPTESSCAVAAIGTLEGSPPDEPTS 1116

  Fly   114 ---------------LGGSRQSTPNGYGSREI-------------------SSPSQNDSDYKYGR 144
                           .|.:....|:.:.|..|                   |..|.:|::..||.
Human  1117 PKRPKSISEPQHSDAEGDAASPLPSEWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDTESDYGG 1181

  Fly   145 FDASALHIAHALKQTEIQKAYNKAREKPIDFYLAREEQAHLEMKHRKEEDDLYRKFASKRAEEDR 209
            .:.|         .||      ...|||     .|....||  .|....:.|.|..:.:..||.|
Human  1182 SEGS---------HTE------PCEEKP-----WRPGSPHL--PHTSLGEALSRAVSPQCPEEPR 1224

  Fly   210 KIQ------DEFQ-------DEWERE 222
            .:.      :.||       ..|.||
Human  1225 AVHAALQRANSFQSPTPSKYQNWRRE 1250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HilNP_611493.2 LIM_Ltd-1 11..70 CDD:188827 19/58 (33%)
BAR <147..>265 CDD:299863 20/89 (22%)
TGc 418..486 CDD:214673
MICAL2NP_001380866.1 Monooxygenase domain. /evidence=ECO:0000250|UniProtKB:Q8VDP3 2..494
UbiH 87..>226 CDD:357568
CH 522..617 CDD:214479
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..714
Nuclear localization signal. /evidence=ECO:0000269|PubMed:24440334 660..681
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..942
LIM_Mical 1002..1056 CDD:188823 19/58 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1072..1094 8/30 (27%)
PHA03247 <1087..1624 CDD:223021 37/195 (19%)
ProQ 1628..1718 CDD:198013
DUF5401 <1773..>1944 CDD:375164
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1700
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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