DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hil and ky

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_001335312.4	Gene:	ky / 795191	ZFINID:	ZDB-GENE-090313-64	Length:	866	Species:	Danio rerio

Alignment Length:	739	Identity:	163/739 - (22%)
Similarity:	286/739 - (38%)	Gaps:	179/739 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PRTNKFVNEQIRGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDYKYGRFDASALHIAHAL 156
            |||...:.|.:..|.::|:      :.|.|.|.:.|.|..|    ::|.|...||   |.|.:.:
Zfish    16 PRTPLKIPEGMSFTTAKVE------TAQQTENSHQSEEAGS----NNDTKKQHFD---LKIENGV 67

  Fly   157 KQTEIQKAYNKAREKPIDFYLAREEQAHLEMKHRKEEDDLYRKFASKRAEEDRKIQDEFQDEWER 221
            .::::|.. :.:::..:|..:....::|.......|..|            .:.:::|...|...
Zfish    68 LKSKLQNV-SGSQKTDMDVKVCLTIKSHQGSSQSVERHD------------PKPLKNESIQENAA 119

  Fly   222 ELQRLTHKFEKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETA 286
            ..:.|...::.:|.                |:|:...::.::...:.|..|:.::
Zfish   120 SHKALCENYDGKLC----------------EEQRPSTKRQLSAESAAKSVSVRKR---------- 158

  Fly   287 ALVDRQSSEMLELISARRSEYMQSESIFLDDEFSEGAVPVEYPLNAPIPAPPAVSKFQ------I 345
            :.|.:...|:::..|. .|..|||...:|                      ||||..|      :
Zfish   159 STVKKSQEEIVKPPSV-ASPGMQSGRPYL----------------------PAVSTSQRKPRKVL 200

  Fly   346 YTDPIEFEDVDRIAISVAQE--DQKTF---------TDLVRQLVGRCTTDIEKARTIFRWITVKN 399
            :|....|..||..::...:|  :::.|         |::.|       .::||.|.|:.|:
Zfish   201 FTRTDVFNKVDAFSMQKGRELREKEEFDAQKIAHAVTEVAR-------NEVEKLRAIWIWL---- 254

  Fly   400 LNAMHFDDDLRGDTPMGL----------LRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAG 454
              ..:.:.|:.|  .:||          :|..|.....|..|...:|...|:.||.:.||||..|
Zfish   255 --CHNIEYDIEG--YLGLSQKICSLDEVIRNGKGVCSGYSNLCVEMCREVGIECVEVSGYSKGIG 315

  Fly   455 YQPGVKFQDSRFRNSWNAVYVAGAWRFVQCNWGARHL-VNAKEAPKQGRGKNDSLRYEYDDHYFL 518
            ||......:....:.||||::.|.|..:...|||..: :.:|...|:           |||.|||
Zfish   316 YQARHSLAEECSDHEWNAVFIDGQWWLLDACWGAGTVDMKSKTFVKR-----------YDDFYFL 369

  Fly   519 TDPREFIYEFYPLQEEWQLLKRPITLREFENLPFVRSLFFRYGLHFA-DEGYGAVVFTDDTGAAT 582
            |:|.|||...:|..:.||||..||:::|||..|...|.|::.||... .:.|..:  |:| |.|.
Zfish   370 TEPSEFINSHFPDDQTWQLLTTPISIQEFEMRPLRTSAFYQLGLTLIHPKQYKTI--TED-GEAI 431

  Fly   583 VRIAMPTDMQSCLIFHYNLKFYDSDEELSYDGVSLKRFVMQSVIGNI------VAFRVHAPCSGA 641
            |.::    ....|.|.|.::.:|....      :||:..:.|..|.:      :..|:.....|.
Zfish   432 VSVS----SSRLLTFSYEMRQHDPQTG------ALKQEEVDSSCGLLSVTHQGMKLRLLPSEPGT 486

  Fly   642 FLLDIFANAVTPQEYLTGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKATRLFGLIPI 706
            :.:.:||..       .|||...:.||..::.|..:|. ..||||.....||........|:...
Zfish   487 YEVKLFARR-------EGEPGALRWVCSLELECPSVQK-RQPLPDNPYLNWGLAAGASALGVKTC 543

  Fly   707 T---HQDPLIFAGRSLDLQFRMSRPL--------TDFMATLHKNGIEEKKLAKYVTHSTLDDIVT 760
            :   .|...:.......:....||||        .:..||..|..| ..::||       :.:|.
Zfish   544 SVAGEQAVEVADDGECKVILNTSRPLMMVCELAHNELNATASKRCI-AMQIAK-------EQLVC 600

  Fly   761 FIINFPEEGQYGLDIYTREL--GG 782
            .:: .|.:|.|.|.::.::.  ||
Zfish   601 NVM-CPYKGFYRLSMFVQDYDSGG 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863	13/117 (11%)
		TGc	418..486	CDD:214673	21/67 (31%)
ky	XP_001335312.4	CYK3	<233..>431	CDD:227604	67/226 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398889at33208
OrthoFinder	1	1.000	-	-		FOG0003908
OrthoInspector	1	1.000	-	-		oto39780
orthoMCL	1	0.900	-	-		OOG6_104626
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3209
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820