Protein Alignment Hil and MICAL3

DIOPT Version :9

• Sequence 1: NP_611493.2
• Gene: Hil / 37328
• FlyBaseID: FBgn0050147
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_056056.2
• Gene: MICAL3 / 57553
• HGNCID: 24694
• Length: 2002
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 79/418 - (18%)
• Similarity: 159/418 - (38%)
• Gaps: 100/418 - (23%)

  Fly    10 TCLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHVPKSG 74
            ||..|.:.||.::|:.  .:..|||..||||.:|.|.|.|..|   .:..:|.:.||..|.....
Human   763 TCYFCQKRVYVMERLS--AEGKFFHRSCFKCEYCATTLRLSAY---AYDIEDGKFYCKPHYCYRL 822

  Fly    75 PGHLDQTSVGIRQALNAPRTNKFVNEQIR-GTRSEVDG--GPLGGSRQSTPNGYGSREISSPS-- 134
            .|:..:....:     ||.:.|.....:: |..::.:|  ..:..|.:.|| |.|...:..||
Human   823 SGYAQRKRPAV-----APLSGKEAKGPLQDGATTDANGRANAVASSTERTP-GSGVNGLEEPSIA 881

  Fly   135 ------------QNDSDYKYGRFDASALH-----------------------IAHALKQTEIQKA 164
                        :|   |:.....|.||.                       :|.:..::|:::.
Human   882 KRLRGTPERIELEN---YRLSLRQAEALQEVPEETQAEHNLSSVLDTGAEEDVASSSSESEMEEE 943

  Fly   165 YNKAREK----PIDFYLAREEQA---HLEMKHRKEEDDLYRKFASKRAEEDRKIQDEFQDEWERE 222
            ..:..|:    |.|......::|   |..:|.:.||:....|......||:.:.::|:::|.|.:
Human   944 GEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEEEEEEEEYEEEEEED 1008

  Fly   223 LQRLTHKFEKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETAA 287
                   :::|...|..:.:: .:..:.|.....:::.::.....:::|...|.....|...:.|
Human  1009 -------YDEEEEESSEAGNQ-RLQQVMHAADPLEIQADVHWTHIREREEEERMAPASESSASGA 1065

  Fly   288 LVDRQSSEMLELISARRSEYMQSES----------IFLDDE--FSEGAVPVEYPLNAPIPAPPAV 340
            .:|....|  |.:.:..:| ::.|:          ..|||:  :|:.....:..|..|.||
Human  1066 PLDENDLE--EDVDSEPAE-IEGEAAEDGDPGDTGAELDDDQHWSDSPSDADRELRLPCPA---- 1123

  Fly   341 SKFQIYTDPIEFEDVDRIAISVAQEDQK 368
                        |....:.:.|:::::|
Human  1124 ------------EGEAELELRVSEDEEK 1139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	20/58 (34%)
		BAR	<147..>265	CDD:299863	22/147 (15%)
		TGc	418..486	CDD:214673
MICAL3	NP_056056.2	Monooxygenase domain. /evidence=ECO:0000250|UniProtKB:Q8VDP3	2..494
		FAD_binding_3	87..>274	CDD:279792
		NAD_binding_8	91..>119	CDD:290186
		CH	524..619	CDD:278723
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..706
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:24440334	663..684
		LIM_Mical	764..818	CDD:188823	20/58 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	835..883		11/48 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	907..1313		39/260 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1335..1776
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1791..1821
		DUF3585	1850..1971	CDD:288945

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810