Protein Alignment Hil and NEB

DIOPT Version :9

• Sequence 1: NP_611493.2
• Gene: Hil / 37328
• FlyBaseID: FBgn0050147
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_001258137.2
• Gene: NEB / 4703
• HGNCID: 7720
• Length: 8560
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 107/572 - (18%)
• Similarity: 191/572 - (33%)
• Gaps: 164/572 - (28%)

  Fly    15 SETVYQVDRVGPLKDFTFFHSGCF---KCVHCGTKLTLKTYFNNQH------------------K 58
            |:.||:.|....:|...:...|..   |....|..|..|.|  .||                  |
Human  1188 SDNVYKEDYNNWMKGIGWIPIGSLDVEKVKKAGDALNEKKY--RQHPDTLKFTSIVDSPVMVQAK 1250

  Fly    59 QDDKEVYCSSHVPKSGPG----HLDQTSVGIRQALNAPRTNKFVNEQIRGTRSEVD----GGPLG 115
            |:.|:|   |.:.....|    |....|..:.|.|.| :.|.:....:...|...|    |..:.
Human  1251 QNTKQV---SDILYKAKGEDVKHKYTMSPDLPQFLQA-KCNAYNISDVCYKRDWYDLIAKGNNVL 1311

  Fly   116 GSRQSTPNGYGSREISSPSQNDSDYKYGRFDASALHIAHALKQTEIQKAYNKAREKPIDFYLARE 180
            |..........||.|:      |||||                   ::||.|::.|.:.|
Human  1312 GDAIPITAAKASRNIA------SDYKY-------------------KEAYEKSKGKHVGF----- 1346

  Fly   181 EQAHLEMKHRKEEDD--LYRKFASKRAEEDRKIQDEFQDEWERELQRLTHKFEKELATSRRSRDE 243
                     |..:||  |.......:.:.||:.:..:::                  |.......
Human  1347 ---------RSLQDDPKLVHYMNVAKLQSDREYKKNYEN------------------TKTSYHTP 1384

  Fly   244 ANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETAALVDRQSSEMLELISARRSEYM 308
            .:::::...:..:|:..|:..::.          |.|..|    |.|..|.|     ..|....:
Human  1385 GDMVSITAAKMAQDVATNVNYKQP----------LHHYTY----LPDAMSLE-----HTRNVNQI 1430

  Fly   309 QSESIFLDDEFSE-----GAVPV-EYPLNAPIPAPPAVS--KFQIYTDPIEFEDV-DRIAISVAQ 364
            ||:::: .||::.     |.:|: ...:.....|..|::  |::.:.|.::|..| |.:.:.:||
Human  1431 QSDNVY-KDEYNSFLKGIGWIPIGSLEVEKVKKAGDALNERKYRQHPDTVKFTSVPDSMGMVLAQ 1494

  Fly   365 EDQKTFTDLVRQLVG-----RCTTDIEKARTIFRWITVKNLNAMHFDDDLRGDTPMGLLRGIKYG 424
            .:.|..:||..::.|     :.|.|.|..:.|...:...|::..|:    :.|....:.:|....
Human  1495 HNTKQLSDLNYKVEGEKLKHKYTIDPELPQFIQAKVNALNMSDAHY----KADWKKTIAKGYDLR 1555

  Fly   425 TESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPG----------------VKFQDSRFRNSWNAV 473
            .::..::..:........|...:.|.|:.|.|.|                .|.|..|   .:...
Human  1556 PDAIPIVAAKSSRNIASDCKYKEAYEKAKGKQVGFLSLQDDPKLVHYMNVAKIQSDR---EYKKG 1617

  Fly   474 YVAGAWRFVQCNWGARH----LVNAKEAPK-QGRGKNDSLRYEYDDHYFLTD 520
            |.|...::        |    :|:...|.| |....|.:.|..|..:..|.|
Human  1618 YEASKTKY--------HTPLDMVSVTAAKKSQEVATNANYRQSYHHYTLLPD 1661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	18/75 (24%)
		BAR	<147..>265	CDD:299863	14/119 (12%)
		TGc	418..486	CDD:214673	12/83 (14%)
NEB	NP_001258137.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141568
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930