DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hil and mical3a

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_021323435.1	Gene:	mical3a / 402881	ZFINID:	ZDB-GENE-050126-2	Length:	2522	Species:	Danio rerio

Alignment Length:	519	Identity:	98/519 - (18%)
Similarity:	178/519 - (34%)	Gaps:	147/519 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YRPNFYES-----TCLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDD 61
            :|..|.::     .|..|.:.||.::|:.  .:..|||..||||.:|||.|.|.:|   ....:|
Zfish  1072 FRKEFPQNIGGSDVCFFCRKRVYVMERLS--AEGKFFHRSCFKCDYCGTTLRLSSY---AFDVED 1131

  Fly    62 KEVYCSSH--------------VPKSGPGH-------------LDQTSVGIRQALNAPR------ 93
            .:.||..|              .|.:.|.:             :|.....|.....|.|
Zfish  1132 GKFYCKPHYCYRLSGVAQRKRPAPAAAPANAKEPQVLAVSPNTVDAPGQAITTQTPAERRPSETE 1196

  Fly    94 ----TNKFVNEQIRGT--RSEVDGGPLGGSRQSTPNGYGSREISS-PSQNDSDYKYGRFDASALH 151
                |...|.::::||  |.|::...|...|:        .|:.. |.:..:::..    :|.|.
Zfish  1197 VNGVTEPSVAKRLKGTPERIELENYRLSMMRE--------EELEEVPEETLAEHNL----SSVLD 1249

  Fly   152 IAHALKQTEIQKAYNKA----REKPIDFYLA-----------REEQAHLEMKHRK----EEDDLY 197
                 |.|:|::..:.:    .|:..|...|           ...:.|.::|...    ::|.|:
Zfish  1250 -----KATDIEEGSSSSESDMEEEDEDAEAAGPSDLGGVPWKEAVELHAKLKGESDPGADDDGLH 1309

  Fly   198 ----RKFASKRAEEDRKIQDEFQDE----------WERELQ------RLTHKFEKELATSRRSRD 242
                .....:..|||.:.:||.::|          ||||||      .|.::.:..:..:|..:.
Zfish  1310 DGDGEMDEDEEEEEDEEDEDEEEEEESSEAGDYFPWERELQSGLWLENLANEEDVSVFKARNLQI 1374

  Fly   243 EANI-------LTMRHEQQKEDLEK------------NMTLRRSKKKESITRKMLEHERYETAAL 288
            :..|       :.|...|.:..||.            |..|.:.....:.:.|.:.||  ...|.
Zfish  1375 QQAIHPVDPLDIQMESHQAEGVLEMPSVSPLGSQPSLNTQLTQPTSSTAPSHKSVRHE--AVRAW 1437

  Fly   289 VDRQSSEMLELISARRSE----------YMQSESIFLDDEFSEGAVPVEYPLNAPIPAPPAVSKF 343
            :|..|.|..|......:|          .:..|.|..|.|....:..::..:..|:......|:.
Zfish  1438 LDSMSGEPCEEDDDPEAEAGSPDFEPGTEIDQEDIPSDAEAEARSRCIDEVVTLPVDNDKTESQG 1502

  Fly   344 QIYTDPIEFEDVDRIAISVAQEDQKTFTDLVRQLVGRCTTDIEKARTIFRWITVKNLNAMHFDD 407
            |::          ..|...:...::...|:|...:.:....||:...:...:.||:..|..|.:
Zfish  1503 QVF----------NTAEKTSANPRELIVDVVLSPIQKPALPIEEVHEVSPVVLVKSPGARFFPE 1556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	22/72 (31%)
		BAR	<147..>265	CDD:299863	32/175 (18%)
		TGc	418..486	CDD:214673
mical3a	XP_021323435.1	FAD_binding_3	91..>239	CDD:332373
		CH	536..636	CDD:306753
		LIM_Mical	1086..1140	CDD:188823	21/58 (36%)
		Herpes_BLLF1	<1488..1803	CDD:330317	12/79 (15%)
		DUF4045	<1840..>1896	CDD:330572
		SMC_N	<2220..>2506	CDD:330553
		DUF3585	2318..2508	CDD:314926
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910