Protein Alignment Hil and KY

DIOPT Version :9

• Sequence 1: NP_611493.2
• Gene: Hil / 37328
• FlyBaseID: FBgn0050147
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_016861776.1
• Gene: KY / 339855
• HGNCID: 26576
• Length: 725
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 152/662 - (22%)
• Similarity: 260/662 - (39%)
• Gaps: 162/662 - (24%)

  Fly   223 LQRLTHKFEKELATSR----RSRDEANILTMRHEQQKEDLEKN----------MTLRRSKKKESI 273
            |||......:.||.||    |:|.        |.|:|:...:.          |.|::.....||
Human    15 LQRRGSALFRALALSRVGQLRARG--------HLQRKQPSVRPRRPGRKGGGIMELKKDINAVSI 71

  Fly   274 TRKMLEHERYETAA---LVDRQS--SEMLEL--------ISARRSEYMQSESIFLDDEFSEGAVP 325
            ...::.|.....||   |.|:|:  |.:|:.        ...||.:.::.      ::|.|..|.
Human    72 DMLLIVHSEKRRAAQGTLSDQQANPSSLLQRGGGFQGVGNGVRRWQKLEG------NDFHENLVE 130

  Fly   326 VEYPLNAPI-------------------PAPPAVSKFQI---------------YTDP------- 349
            .::|....:                   ..|..:.||.:               .|.|
Human   131 KQHPQQPQVITSYNSQGTQLTVEVHPRDAMPQLLKKFSLAKRMYDTGLQGDKNGNTRPRQPGGKD 195

  Fly   350 ---------------IEFEDVDRIAISVAQEDQKTFTD-LVRQLVGRCTTDIEKARTIFRWITVK 398
                           ::.:..:::.|..:|...|:..| ||..|:....||:|:.|.|:.||
Human   196 AHAYPWDRSSLKSMSLDLQQFEKLDIYASQVTAKSGLDELVSDLLQEAHTDLERVRAIWIWI--- 257

  Fly   399 NLNAMHFD------DDLRGDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQP 457
             .:.:.:|      .|.:...|..:||..|...:.|..||:|:|..||:.|:.:.||||..|||.
Human   258 -CHHIEYDIAAAQEKDRQAFKPTDILRTQKTNCDGYAGLFERMCRLAGVQCMTVPGYSKGFGYQT 321

  Fly   458 GVKFQDSRFRNSWNAVYVAGAWRFVQCNWGARHLVNAKEAPKQGRGKNDSL----RYEYDDHYFL 518
            |..| ...|.::|||||:.|.|..|...||:              |..|::    .:.|::.|||
Human   322 GQSF-SGEFDHAWNAVYLEGRWHLVDSTWGS--------------GLVDTITSKFTFLYNEFYFL 371

  Fly   519 TDPREFIYEFYPLQEEWQLLKRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATV 583
            |.|..||.:.:|..:.|||||.|.:||:|||..:.:|.|:..|:..|......:...:.....|:
Human   372 THPALFIEDHFPDNKNWQLLKPPQSLRQFENNMYHKSEFYNKGMLSAHPETSMIRTVNGKATVTI 436

  Fly   584 RIAMPTDMQSCLIFHYNLKFYDSDEELSYDGVSLKRFVMQSVIGNIVAFRVHAPCSGAFLLDIFA 648
            ....||      :|.:.|     :.:..:..:||::        |.:...|:.|..|...|.|||
Human   437 ESCAPT------LFMFML-----NGKQEHGLLSLRK--------NGMKLEVYPPTMGTHKLQIFA 482

  Fly   649 NAVTPQEYLTGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKATRLFGLIPITHQDPLI 713
            .         |....:.||.::.:.|..:. :.|.||.......||:..:...|::..:|.||:|
Human   483 K---------GNSDIYSSVLEYTLKCNYVD-MGVQLPAELHQPVGPSWFSEQMGIMKPSHPDPII 537

  Fly   714 FA--GRSLDLQFRMSRPLTDFMATLHKNG--IEEKKLAKYVTHSTLDDIVTFIINFPEEGQYGLD 774
            ..  || ..:.|.:...: :.:|:||.:.  |.|:...:|:.....:......:..|..|::.|.
Human   538 HTSDGR-CSISFSVEEGI-NVLASLHGDDGPITEETQRRYIFQLHREKQTELKVQLPHAGKFALK 600

  Fly   775 IYTRELGGPQHH 786
            |:.::...|.::
Human   601 IFVKKRQEPGNY 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863	13/55 (24%)
		TGc	418..486	CDD:214673	29/67 (43%)
KY	XP_016861776.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5279
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4457
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398889at33208
OrthoFinder	1	1.000	-	-		FOG0003908
OrthoInspector	1	1.000	-	-		oto88644
orthoMCL	1	0.900	-	-		OOG6_104626
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3261
SonicParanoid	1	1.000	-	-		X3209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.690