DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hil and Neb

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_038962186.1	Gene:	Neb / 311029	RGDID:	1311134	Length:	7519	Species:	Rattus norvegicus

Alignment Length:	455	Identity:	81/455 - (17%)
Similarity:	158/455 - (34%)	Gaps:	136/455 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 RGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDYKYGRFDASALHIAHALKQTEIQKAYNK 167
            :|.....|..|:..::       .||.|:      |||||                   ::||.|
  Rat  1301 KGNNVLADAIPITAAK-------SSRNIA------SDYKY-------------------KEAYEK 1333

  Fly   168 AREKPIDFYLAREEQAHLEMKHRKEEDD--LYRKFASKRAEEDRKIQDEFQDEWERELQRLTHKF 230
            |:.|.:.|              |..:||  |.......:.:.||:.:..:::
  Rat  1334 AKGKHVGF--------------RSLQDDPKLVHYMNVAKLQSDREYKKNYEN------------- 1371

  Fly   231 EKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETAALVDRQSSE 295
                 |........:::::...:..:|:..|:..::.          :.|..|         ..:
  Rat  1372 -----TKTSYHTPGDMVSITAARMAQDVATNVNYKQP----------IHHYTY---------LPD 1412

  Fly   296 MLELISARRSEYMQSESIFLDDEFSE-----GAVPV-EYPLNAPIPAPPAVS--KFQIYTDPIEF 352
            .|.|...|.:..:||:::: .||::.     |.:|: ...:.....|..|::  |::.:.|.|:|
  Rat  1413 SLSLEHTRNANQIQSDNVY-KDEYNSFFKGIGWIPIGSLEVEKAKKAGDALNERKYRQHPDTIKF 1476

  Fly   353 EDV-DRIAISVAQEDQKTFTDLVRQLVG-----RCTTDIEKARTIFRWITVKNLNAMHFDDDLRG 411
            ..| |.:.:.:||::.|..:||..::.|     :.|.|.|..:.|...:...|::..|:    :.
  Rat  1477 TSVPDSMGMVLAQQNTKQLSDLNYKVEGEKLKHKYTMDPELPQFIQAKVNAINMSDAHY----KA 1537

  Fly   412 DTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPG----------------VK 460
            |....|.:|.....::..::..:........|...:.|.|:.|.|.|                .|
  Rat  1538 DWKKTLAKGYDLRPDAIPIVAAKSSRNIASDCKYKEAYEKAKGKQIGFLSLQDDPKLVHYMNVAK 1602

  Fly   461 FQDSRFRNSWNAVYVAGAWRFVQCNWGARH----LVNAKEAPK-QGRGKNDSLRYEYDDHYFLTD 520
            .|..|   .:...|.|...|:        |    :.:...|.| |....|.:.|..|.::..|.|
  Rat  1603 IQSDR---EYKKGYEASKTRY--------HTPLDMFSVTAAKKSQEVATNSNYRQPYHNYTLLPD 1656

Fly 521 520
Rat 1657 1656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863	15/119 (13%)
		TGc	418..486	CDD:214673	13/83 (16%)
Neb	XP_038962186.1	NEBU	178..207	CDD:128523
		NEBU	248..278	CDD:128523
		Streccoc_I_II	270..>653	CDD:411384
		Nebulin	573..600	CDD:395708
		Nebulin	611..638	CDD:395708
		Nebulin	784..811	CDD:395708
		Nebulin	820..847	CDD:395708
		Nebulin	858..885	CDD:395708
		NEBU	888..918	CDD:128523
		NEBU	919..948	CDD:128523
		Nebulin	1102..1129	CDD:395708
		NEBU	1163..1192	CDD:128523
		NEBU	1232..1262	CDD:128523
		NEBU	1267..1297	CDD:128523
		Nebulin	1346..1373	CDD:395708	5/44 (11%)
		NEBU	1476..1506	CDD:128523	9/29 (31%)
		NEBU	1511..1541	CDD:128523	7/33 (21%)
		Nebulin	1590..1617	CDD:395708	5/29 (17%)
		NEBU	1756..1785	CDD:128523
		Nebulin	1834..1861	CDD:395708
		NEBU	1964..1993	CDD:128523
		NEBU	2000..2029	CDD:128523
		Nebulin	2078..2105	CDD:395708
		NEBU	2244..2273	CDD:128523
		Nebulin	2322..2349	CDD:395708
		NEBU	2352..2382	CDD:128523
		NEBU	2451..2481	CDD:128523
		Nebulin	2491..2518	CDD:395708
		Nebulin	2565..2592	CDD:395708
		Nebulin	2734..2761	CDD:395708
		Nebulin	2808..2835	CDD:395708
		Nebulin	3051..3078	CDD:395708
		NEBU	3180..3210	CDD:128523
		Nebulin	3294..3321	CDD:395708
		NEBU	3423..3453	CDD:128523
		Nebulin	3463..3490	CDD:395708
		Nebulin	3603..3630	CDD:395708
		NEBU	3702..3731	CDD:128523
		Nebulin	3780..3807	CDD:395708
		NEBU	3909..3938	CDD:128523
		NEBU	3945..3974	CDD:128523
		Nebulin	3985..4012	CDD:395708
		NEBU	4152..4182	CDD:128523
		NEBU	4188..4217	CDD:128523
		Nebulin	4228..4254	CDD:395708
		Nebulin	4266..4293	CDD:395708
		Nebulin	4332..4359	CDD:395708
		NEBU	4395..4425	CDD:128523
		Nebulin	4471..4498	CDD:395708
		NEBU	4638..4668	CDD:128523
		NEBU	4674..4703	CDD:128523
		Nebulin	5129..5156	CDD:395708
		Nebulin	5584..5611	CDD:395708
		Nebulin	5971..5998	CDD:395708
		NEBU	6176..6206	CDD:128523
		NEBU	6602..6632	CDD:128523
		NEBU	6712..6740	CDD:128523
		Nebulin	6789..6815	CDD:395708
		NEBU	6855..6881	CDD:128523
		NEBU	7041..7070	CDD:128523
		NEBU	7134..7159	CDD:128523
		NEBU	7165..7194	CDD:128523
		Nebulin	7267..7294	CDD:395708
		SH3_Nebulin_C	7462..7519	CDD:212866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930