DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hil and Nrap

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_006231706.1	Gene:	Nrap / 307982	RGDID:	1306731	Length:	1728	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	120/644 - (18%)
Similarity:	200/644 - (31%)	Gaps:	211/644 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHVPKSGP 75
            |.||...||..::|..: |.| :|..||.|..|...|::..:.::|     |:.||.:|.||:.
  Rat     6 CSRCGYGVYPAEKVSCI-DQT-WHKACFHCEVCKMMLSVNNFVSHQ-----KKPYCHAHNPKNN- 62

  Fly    76 GHLDQTSVGIRQALNAPRTNKFVNEQIRGTRSEVDG---------------GPLGGSRQSTPN-- 123
               ..||| .|..||....|...  .:.||..:.||               |....||.....
  Rat    63 ---TFTSV-YRTPLNLTLKNSVA--AMGGTDGKEDGEQFKSVLHWDMKSKAGAGAASRLMNERDY 121

  Fly   124 --GYGS------------------------REISSPSQNDSDYKYGRFDA---SALHIAHALKQT 159
              |||.                        ||.......:.....|.|.|   .|...|.|..|.
  Rat   122 WPGYGEGNTWCPGALPDPEIVRMVEARQSLREQGYTEDGEQPQGKGSFPAMITPAYQRAKAANQL 186

  Fly   160 EIQKAYNKAREKPIDFY---------LAREEQAHLEMKHRKEEDDLYRK--------------FA 201
            ..|..|.:..::.:..:         |.......|:...|..||...::              .|
  Rat   187 ASQVQYKRGHDERVSTFTPVADTPELLRANAGGQLQNDVRYTEDGGQQRGKGSFPAMITPAYQIA 251

  Fly   202 SKRAEEDRKIQDEFQDEWERELQRLTHKFEKELATSRRSRDEANILTMRHEQQKEDLEKNM---- 262
            .:.||....::  :..::.||::.:......|...::.|.|...      :...|:.|::.
  Rat   252 KRAAELASDVR--YHQQYHREMKGVASPVGAEGTMTKDSIDRCG------QTYSEECEEHRGKGS 308

  Fly   263 -------TLRRSKKKESIT---------RKMLEHERYETAALVDRQSSEMLELISARRSEYMQSE 311
                   ..:.:||...:.         .||.....:.:.|..|....:..:.:|...||....:
  Rat   309 FPAMITPAYQNAKKANELASDIKYRQDFHKMKGAAHFHSLAAQDNLVLQRAQNVSKLVSEVEYKK 373

  Fly   312 SIFLDDEFSEGAVPVEYPLNAPIPAPPAVSKFQIYTDPIEFEDVDRIAISVAQEDQKTFTDLVRQ 376
            .:    |.|:|     :.:|              |.:..:|.:|.:|:
  Rat   374 GL----ENSKG-----HSIN--------------YCETPQFRNVSKIS----------------- 398

  Fly   377 LVGRCTTDIEKARTIFRWITVKNLNAMHFDDDLRG-------DTPMGLLRGIKYGTESYHVLFKR 434
               :.|:|              |....::...|||       |..|  |..:|.|:.:.:|.:|
  Rat   399 ---KFTSD--------------NKYKENYQTHLRGHYEGVGMDRRM--LHALKVGSLASNVAYK- 443

  Fly   435 LCSYAGLHCVVIKGYSKSAG--YQPGVK---FQDSRFRNSWNAV---YVAGAWRFVQCNWGARHL 491
             ..|.  |.||...|..:|.  ||..:|   .:|..:|.:.:.:   .|....:.||....|:.|
  Rat   444 -ADYK--HDVVDYNYPATATPFYQTTMKLAPLKDVNYRQNIDRLKFSSVTNTPQIVQAKINAQQL 505

  Fly   492 VNAKEAPKQGRGKNDSLRYEYDDHYFLTDPREF-----------IYEFYPLQEEWQLLK 539
            .:........|.|   |.|        |.|::.           ::.....:|.||..|
  Rat   506 SHVNYRADYERNK---LNY--------TLPQDAPQMLKAKANAQLFSEVKYKEGWQKTK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	18/58 (31%)
		BAR	<147..>265	CDD:299863	22/154 (14%)
		TGc	418..486	CDD:214673	19/75 (25%)
Nrap	XP_006231706.1	LIM_N_RAP	6..58	CDD:188830	18/58 (31%)
		Nebulin	314..340	CDD:279252	3/25 (12%)
		NEBU	486..516	CDD:128523	5/29 (17%)
		NEBU	521..551	CDD:128523	5/37 (14%)
		Nebulin	563..589	CDD:279252
		NEBU	626..656	CDD:128523
		NEBU	725..755	CDD:128523
		NEBU	760..790	CDD:128523
		NEBU	968..998	CDD:128523
		NEBU	1003..1031	CDD:128523
		Nebulin	1047..1071	CDD:279252
		NEBU	1246..1276	CDD:128523
		NEBU	1355..1380	CDD:128523
		NEBU	1598..1624	CDD:128523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335255
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840