DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hil and Mical1

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_038954550.1	Gene:	Mical1 / 294520	RGDID:	1309386	Length:	1058	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	79/398 - (19%)
Similarity:	131/398 - (32%)	Gaps:	136/398 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ESTCLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHVPK 72
            |..|..|.:.:|.::|.  ..|..|||.|||.|..|  :.||:.....|: ..|...||..|:|:
  Rat   678 EDVCELCGKRLYILERF--CVDGHFFHRGCFCCRTC--EATLRPGGYGQY-PGDGYFYCLQHLPQ 737

  Fly    73 SGPGHLDQTSVGIRQALNAPRTNKFVNEQIRGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQND 137
            ......|.......|.|..|..:         |.......|:....:::|       :.||||..
  Rat   738 EDQKEADNNGSPENQELPTPGDS---------TTQSGPSSPVPPVTEASP-------VPSPSQPA 786

  Fly   138 SDY----KYGRFDASALHI--------------------AHALKQTEIQKAYNKAREKPIDFYLA 178
            ...    ...|...|:|:|                    ..:||.:.:.....:|.:.|......
  Rat   787 RRLIRLSSVERLRLSSLNIIPDSGVEPPPKPPRSCLDLAQESLKSSFMGWGVLRAPQVPEAIEKG 851

  Fly   179 REEQAHLEMKHRKEED-------------DL------------------------YRKFASKRAE 206
            .||:...|.:..:||:             ||                        :|:...:||:
  Rat   852 EEEEEEEEEEEEEEEELPPPLALEVEQGPDLTAPTLPQSLLTLAKNSGDMTKYPTWRRTLMRRAK 916

  Fly   207 EDRKIQDEFQDEWER-----ELQRLTHKFE---KELATSRRSRDEANILTMRHEQQKEDLEKNMT 263
            |         :|.:|     .:||..::.|   :||.|.....:.|    :|.|....:.:|.:.
  Rat   917 E---------EEMKRFCKAQAIQRRLNEIEAAMRELETEGMKLEVA----LRKESSSPEKQKKLW 968

  Fly   264 LRR-----SKKKESIT-----------------RKMLEHE-----RYET-AALVDRQSSE----- 295
            |.:     .||...:|                 ::.|:||     |.|| ....||.|.:
  Rat   969 LEQLLQLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHEFRGINREETLKTQADRLSEDRVLRK 1033

  Fly   296 MLELISAR 303
            :|::::.|
  Rat  1034 LLDVVNQR 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	19/58 (33%)
		BAR	<147..>265	CDD:299863	30/182 (16%)
		TGc	418..486	CDD:214673
Mical1	XP_038954550.1	FAD_binding_3	85..>122	CDD:396193
		CH_MICAL1	506..611	CDD:409045
		LIM	681..734	CDD:413332	19/57 (33%)
		DUF3585	929..1056	CDD:403377	25/117 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900