DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hil and Neb

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_006497839.1	Gene:	Neb / 17996	MGIID:	97292	Length:	7523	Species:	Mus musculus

Alignment Length:	455	Identity:	82/455 - (18%)
Similarity:	158/455 - (34%)	Gaps:	136/455 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 RGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDYKYGRFDASALHIAHALKQTEIQKAYNK 167
            :|.....|..|:..::       .||.|:      |||||                   ::||.|
Mouse  1301 KGNNVLADAIPITAAK-------SSRNIA------SDYKY-------------------KEAYEK 1333

  Fly   168 AREKPIDFYLAREEQAHLEMKHRKEEDD--LYRKFASKRAEEDRKIQDEFQDEWERELQRLTHKF 230
            |:.|.:.|              |..:||  |.......:.:.||:.:..:::
Mouse  1334 AKGKHVGF--------------RSLQDDPKLVHYMNVAKLQSDREYKKNYEN------------- 1371

  Fly   231 EKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRSKKKESITRKMLEHERYETAALVDRQSSE 295
                 |........:::::...:..:|:..|:..::.          |.|..|         ..:
Mouse  1372 -----TKTSYHTPGDMVSITAARMAQDVATNVNYKQP----------LHHYTY---------LPD 1412

  Fly   296 MLELISARRSEYMQSESIFLDDEFSE-----GAVPV-EYPLNAPIPAPPAVS--KFQIYTDPIEF 352
            .|.|...|.:..:||:::: .||::.     |.:|: ...:.....|..|::  |::.:.|.|:|
Mouse  1413 ALSLEHTRNANQIQSDNVY-KDEYNSFFKGIGWIPIGSLEVEKAKKAGEALNERKYRQHPDTIKF 1476

  Fly   353 EDV-DRIAISVAQEDQKTFTDLVRQLVG-----RCTTDIEKARTIFRWITVKNLNAMHFDDDLRG 411
            ..| |.:.:.:||::.|..:||..::.|     :.|.|.|..:.|...:...|::..|:    :.
Mouse  1477 TSVPDSMGMVLAQQNTKQLSDLNYKVEGEKMKHKYTMDPELPQFIQAKVNAINMSDAHY----KA 1537

  Fly   412 DTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPG----------------VK 460
            |....|.:|.....::..::..:........|...:.|.|:.|.|.|                .|
Mouse  1538 DWKKTLAKGYDLRPDAIPIVAAKSSRNIASDCKYKEAYEKARGKQIGFLSLQDDPKLVHYMNVAK 1602

  Fly   461 FQDSRFRNSWNAVYVAGAWRFVQCNWGARH----LVNAKEAPK-QGRGKNDSLRYEYDDHYFLTD 520
            .|..|   .:...|.|...|:        |    :.:...|.| |....|.:.|..|.::..|.|
Mouse  1603 IQSDR---EYKKGYEASKTRY--------HTPLDMFSVTAAKKSQEVATNSNYRQPYHNYTLLPD 1656

Fly 521 520
Mouse 1657 1656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863	15/119 (13%)
		TGc	418..486	CDD:214673	13/83 (16%)
Neb	XP_006497839.1	Nebulin	79..105	CDD:366355
		Nebulin	151..175	CDD:366355
		NEBU	178..207	CDD:128523
		NEBU	248..278	CDD:128523
		NEBU	532..562	CDD:128523
		Nebulin	575..601	CDD:366355
		Nebulin	613..639	CDD:366355
		Nebulin	786..812	CDD:366355
		Nebulin	822..848	CDD:366355
		Nebulin	860..886	CDD:366355
		NEBU	888..918	CDD:128523
		NEBU	919..948	CDD:128523
		Nebulin	1104..1130	CDD:366355
		NEBU	1163..1192	CDD:128523
		NEBU	1232..1262	CDD:128523
		NEBU	1267..1297	CDD:128523
		Nebulin	1310..1336	CDD:366355	13/57 (23%)
		Nebulin	1348..1374	CDD:366355	4/43 (9%)
		NEBU	1476..1506	CDD:128523	9/29 (31%)
		NEBU	1511..1541	CDD:128523	7/33 (21%)
		NEBU	1756..1785	CDD:128523
		Nebulin	1836..1862	CDD:366355
		NEBU	1895..1923	CDD:128523
		NEBU	1964..1993	CDD:128523
		NEBU	2000..2029	CDD:128523
		Nebulin	2042..2068	CDD:366355
		Nebulin	2080..2106	CDD:366355
		NEBU	2244..2273	CDD:128523
		Nebulin	2324..2350	CDD:366355
		NEBU	2451..2481	CDD:128523
		Nebulin	2567..2593	CDD:366355
		NEBU	2730..2759	CDD:128523
		Nebulin	2810..2836	CDD:366355
		Nebulin	3053..3079	CDD:366355
		NEBU	3180..3210	CDD:128523
		Nebulin	3296..3322	CDD:366355
		NEBU	3423..3453	CDD:128523
		NEBU	3567..3597	CDD:128523
		Nebulin	3606..3631	CDD:366355
		Nebulin	3782..3808	CDD:366355
		NEBU	3909..3938	CDD:128523
		NEBU	3945..3974	CDD:128523
		Nebulin	3992..4013	CDD:366355
		NEBU	4152..4182	CDD:128523
		NEBU	4188..4217	CDD:128523
		Nebulin	4230..4256	CDD:366355
		Nebulin	4268..4294	CDD:366355
		Nebulin	4335..4360	CDD:366355
		NEBU	4395..4425	CDD:128523
		Nebulin	4475..4499	CDD:366355
		NEBU	4638..4668	CDD:128523
		NEBU	4674..4703	CDD:128523
		Nebulin	4715..4741	CDD:366355
		Nebulin	5131..5157	CDD:366355
		Nebulin	5973..5999	CDD:366355
		NEBU	6211..6241	CDD:128523
		Nebulin	6537..6563	CDD:366355
		Nebulin	6645..6670	CDD:366355
		NEBU	6747..6775	CDD:128523
		NEBU	6819..6849	CDD:128523
		NEBU	6890..6916	CDD:128523
		NEBU	7045..7074	CDD:128523
		NEBU	7138..7163	CDD:128523
		Nebulin	7273..7299	CDD:366355
SH3_Nebulin_C	7466..7523	CDD:212866
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930