DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hil and ltd-1

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_495697.2	Gene:	ltd-1 / 174301	WormBaseID:	WBGene00003089	Length:	723	Species:	Caenorhabditis elegans

Alignment Length:	811	Identity:	404/811 - (49%)
Similarity:	521/811 - (64%)	Gaps:	98/811 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLRCSETVYQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQDDKEVYCSSHVPKSGP 75
            |.||.:.||..|:||||||.||||.|||||..|||:|.||||.||::..:|||||||:|||.:||
Worm     7 CNRCGKQVYPTDKVGPLKDSTFFHQGCFKCYICGTRLALKTYCNNRNDINDKEVYCSNHVPIAGP 71

  Fly    76 GHLDQTSVGIRQALNAPRTNKFVNEQIRGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDY 140
            ..|...|.                                       ||.|..     .:|::..
Worm    72 HDLPMAST---------------------------------------NGSGKN-----LENNNHV 92

  Fly   141 KYGRF-DA--SALHIAHALKQTEIQKAYNKAREKPIDFYLAREEQAHLEMKHRKEEDDLYRKFAS 202
            |.|.: ||  |.:.||||:|.|::.:.|.|...:...:.:..:.|..||:.|||:|||||..|..
Worm    93 KNGNWIDAGLSDMKIAHAMKATQVARPYPKISHEGAKYVVDYDTQTRLELLHRKDEDDLYESFQD 157

  Fly   203 KRAEEDRKIQDEFQDEWERELQRLTHKFEKELATSRRSRDEANILTMRHEQQKEDLEKNMTLRRS 267
            ||..|..:.:.|..:|||:.|.....|:||         .::|:       :|:||.:.:|::|.
Worm   158 KRVREAEEFEKENTEEWEKALAEFAKKYEK---------GQSNM-------KKDDLIRQLTIKRE 206

  Fly   268 KKKESITRKMLEHERYETAALVDRQSSEMLELISARRSEYMQSESIFLDDEFSEGAVPVEYPLNA 332
            ||.|::..|..|.||::||.|||||:.|||||..|.||||..                ::||...
Worm   207 KKLETLHTKRKERERHQTAELVDRQAKEMLELFKASRSEYSN----------------LQYPSTP 255

  Fly   333 PIPAPPAVSKFQIYTDPIEFEDVDRIAISVAQEDQKTFTDLVRQLVGRCTTDIEKARTIFRWITV 397
            |.|.||:.||.:|||....|..:|.:||..|:.:..:||||:|.|.....:|::.||.|:||||:
Worm   256 PPPVPPSCSKREIYTTTDYFSSIDEVAIHCARNEVASFTDLIRTLSSGARSDVDVARAIYRWITI 320

  Fly   398 KNLNAMHFDDDLRGDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPGVKFQ 462
            ||||.|.|||.::.|||||||||||||||||||||||||||||||||||||:|||||||||..|.
Worm   321 KNLNTMIFDDSIQNDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGFSKSAGYQPGYSFD 385

  Fly   463 DSRFRNSWNAVYVAGAWRFVQCNWGARHLVNAKEAPKQGRGKNDSLRYEYDDHYFLTDPREFIYE 527
            |.||||:||||::.|:|||||||||||||||||:...:.: .:.:||||||||||:||..|||||
Worm   386 DHRFRNTWNAVFLDGSWRFVQCNWGARHLVNAKDGSHEAK-TDGNLRYEYDDHYFMTDSEEFIYE 449

  Fly   528 FYPLQEEWQLLKRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATVRIAMPTDMQ 592
            |:|....||||.||::|.:||.:||||||||:|.|.|.|....:.|:||.:|||::.|.:|....
Worm   450 FFPSDHAWQLLPRPLSLLQFERIPFVRSLFFKYNLSFIDNKLESTVYTDKSGAASISIRLPPKGD 514

  Fly   593 SCLIFHYNLKFYDSDEELSYDGVSLKRFVMQSVIGNIVAFRVHAPCSGAFLLDIFANAVTPQEYL 657
            | |||||||||:|| ||.:..|:||||||||||..::|.||||||.:...|||||||:|:...||
Worm   515 S-LIFHYNLKFFDS-EENTISGMSLKRFVMQSVTEDVVTFRVHAPSTRPLLLDIFANSVSSGAYL 577

  Fly   658 TGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKATRLFGLIPITHQDPLIFAGRSLDLQ 722
            ||:|:|||||||||:.||.||.:|||||:||||||||.||||||||:||:|.|.:|..||.::::
Worm   578 TGQPIKFKSVCKFKVVCESLQVIMVPLPECASGEWGPAKATRLFGLLPISHPDAIINTGRYVEIR 642

  Fly   723 FRMSRPLTDFMATLHKNGIEEKKLAKYVTHSTLDDIVTFIINFPEEGQYGLDIYTRELGGPQHHH 787
            |||:|||::|:|:||:|..:::.|......:...|:|...|.||.|||||||||||:
Worm   643 FRMTRPLSEFVASLHRNRTDDRALQACTRSALKGDMVYIQIEFPGEGQYGLDIYTRQ-------- 699

  Fly   788 HHNNNNSSSSSGEKHLLTHCCKYLINSSKRN 818
                 :....:| |.||||||||||:|  ||
Worm   700 -----DDQLING-KQLLTHCCKYLIHS--RN 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	38/58 (66%)
		BAR	<147..>265	CDD:299863	38/119 (32%)
		TGc	418..486	CDD:214673	57/67 (85%)
ltd-1	NP_495697.2	LIM_Ltd-1	7..66	CDD:188827	38/58 (66%)
ltd-1	NP_495697.2	CYK3	<295..>484	CDD:227604	131/189 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162258
Domainoid	1	1.000	686	1.000	Domainoid score	I57
eggNOG	1	0.900	-	-		E1_COG5279
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H105801
Inparanoid	1	1.050	774	1.000	Inparanoid score	I270
Isobase	1	0.950	-	0	Normalized mean entropy	S7517
OMA	1	1.010	-	-		QHG29027
OrthoDB	1	1.010	-	-		D398889at33208
OrthoFinder	1	1.000	-	-		FOG0003908
OrthoInspector	1	1.000	-	-		oto20356
orthoMCL	1	0.900	-	-		OOG6_104626
Panther	1	1.100	-	-	LDO	PTHR47020
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3261
SonicParanoid	1	1.000	-	-		X3209
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750