DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hil and NEBL

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_006384.1	Gene:	NEBL / 10529	HGNCID:	16932	Length:	1014	Species:	Homo sapiens

Alignment Length:	731	Identity:	135/731 - (18%)
Similarity:	259/731 - (35%)	Gaps:	230/731 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YQVDRVGPLKDFTFFHSGCFKCVHCGTKLTLKTYFNNQHKQD-DKEVYCSSHVPKSGPGHLDQTS 82
            |:.::..|:.:|....|      :..:|...|......:|:| :||:...|.:      .||:|.
Human   343 YEKNKGKPMLEFVETPS------YQASKEAQKMQSEKVYKEDFEKEIKGRSSL------DLDKTP 395

  Fly    83 --VGIRQALNAPRTNKF---VNEQIRGTRSEVDGGPLGGSRQSTPNGYGSREISSPSQNDSDY-- 140
              :.::...|..|..::   :..:|:|...|::...|...|...     :.|::|..:...|.
Human   396 EFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKR-----ASEMASEKEYKKDLES 455

  Fly   141 ----KYGRFDASALHIAHALKQTEI--QKAYNKAREKPI------------DFYLAREEQAHLEM 187
                |..:.....|.:.||.|..||  :|.|.:..|..|            |...|::..   ||
Human   456 IIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKAS---EM 517

  Fly   188 KHRKE-EDDLYRKFASK------------RAEEDRKI--QDEFQDEWER------------ELQR 225
            ..:|: :.||..:...|            ||:...:|  |.:::||.|:            |:||
Human   518 ASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQR 582

  Fly   226 L--THK------FEKELATSRRSRDEANILTMRHEQQ-------KEDLEKNMT-------LRRSK 268
            :  |.:      ::||:......:|...|..::..||       ||:: |:.|       |:|.|
Human   583 IKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEI-KHATAISDPPELKRVK 646

  Fly   269 K-KESITRKMLEHERYETAALVDRQSSEMLELISARRSEYMQSESIFLDDEFSEGAVPVEYPLNA 332
            : :::|:....:.:.|:...:     |...|:...||:: .|..::....|...|..
Human   647 ENQKNISNLQYKEQNYKATPV-----SMTPEIERVRRNQ-EQLSAVKYKGELQRGTA-------- 697

  Fly   333 PIPAPPAVSKFQIYTDPIEFEDVDRIAISVAQEDQKTFTDL-VRQLVGRCTT-----DIEKARTI 391
             |..||.:.:                    |:|:||..::: .|..:||.||     ::|:.:.
Human   698 -ISDPPELKR--------------------AKENQKNISNVYYRGQLGRATTLSVTPEMERVKK- 740

  Fly   392 FRWITVKNLNAMHFDDD---LRG------DTPMGLLRGIKYGTE-----SYHVLFKRL------- 435
                ..:|::::.:..|   ::|      |||  .:|.:|....     .||..|::.
Human   741 ----NQENISSVKYTQDHKQMKGRPSLILDTP--AMRHVKEAQNHISMVKYHEDFEKTKGRGFTP 799

  Fly   436 -------------------CSYAGLHCVVIKGYSKSAGYQPGVKFQDSRFRNSWNAVYVAGAWRF 481
                               .:|.|:|..:::     ...:||:......:|....:::....
Human   800 VVDDPVTERVRKNTQVVSDAAYKGVHPHIVE-----MDRRPGIIVDLKVWRTDPGSIFDLDP--- 856

  Fly   482 VQCNWGAR--HLVNAKEAPKQGRGKNDSLRYEYDDHYF-----------LTDPREFIYEFYPLQE 533
            ::.|..:|  |:::.|.:             .|..|:.           |.|.|..|.|.||...
Human   857 LEDNIQSRSLHMLSEKAS-------------HYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFS 908

  Fly   534 EWQLLKRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATVRIAMPTDMQSCLIFH 598
            ....:.||    ..|..|.:...:.:  .|  .:|||   :...|..:::|....:.........
Human   909 CCSEVTRP----SDEGAPVLPGAYQQ--SH--SQGYG---YMHQTSVSSMRSMQHSPNLRTYRAM 962

  Fly   599 YNLKFYDSDEELSYDG 614
            |:....|.||....||
Human   963 YDYSAQDEDEVSFRDG 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827	11/51 (22%)
		BAR	<147..>265	CDD:299863	39/180 (22%)
		TGc	418..486	CDD:214673	11/98 (11%)
NEBL	NP_006384.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Nebulin 1	29..63
		NEBU	30..60	CDD:128523
		Nebulin 2	64..99
		Nebulin 3	100..136
		Nebulin 4	137..172
		Nebulin 5	173..205
		Nebulin 6	206..241
		Nebulin 7	242..278
		Nebulin 8	279..313
		Neuromodulin_N	<294..712	CDD:331332	81/424 (19%)
		Nebulin 9	314..348		1/4 (25%)
		Nebulin 10	349..385		9/41 (22%)
		Nebulin 11	386..422		7/41 (17%)
		Nebulin 12	423..459		6/40 (15%)
		Nebulin 13	460..496		11/35 (31%)
		Nebulin 14	497..533		7/38 (18%)
		Nebulin 15	534..569		8/34 (24%)
		Nebulin 16	570..599		5/28 (18%)
		Nebulin 17	600..635		7/35 (20%)
		Nebulin 18	636..666		5/29 (17%)
		Nebulin 19	667..693		6/31 (19%)
		Nebulin 20	694..728		11/62 (18%)
		NEBU	727..756	CDD:128523	5/33 (15%)
		Nebulin 21	729..759		3/34 (9%)
		Nebulin 22	760..794		8/35 (23%)
		NEBU	762..791	CDD:128523	8/30 (27%)
		Nebulin 23	795..830		3/34 (9%)
		Linker	836..953		25/143 (17%)
		SH3_Nebulette_C	957..1014	CDD:212868	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930