DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hil and LOC101730654

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_012826884.2	Gene:	LOC101730654 / 101730654	-ID:	-	Length:	950	Species:	Xenopus tropicalis

Alignment Length:	581	Identity:	123/581 - (21%)
Similarity:	209/581 - (35%)	Gaps:	189/581 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 VDRIAISVAQEDQKTFTDLVRQLVGRCTTDIEKARTIFRWITVKNLNAMHFDDDLRGDTPMGLL- 418
            :|..|:.|  ...:|...||:.|:...:||:||.|.|:.||      ..|.:.|:......||:
Frog   105 LDAYALKV--NGHRTLELLVKDLLCEASTDLEKTRAIWIWI------CHHIEYDVAETKSKGLVP 161

  Fly   419 -------RGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPGVKFQDSRFRNSWNAVYVA 476
                   :..|.....|.:||:|:||.|.:.|..:.||.|...:..|..       ::||.||:.
Frog   162 PDPDATFQSRKTVCAGYPLLFQRMCSLADIQCETVCGYRKGQTFSEGPD-------HAWNVVYLE 219

  Fly   477 GAWRFVQCNWGARHLVNAKEAPKQGRGKNDSLR---YEYDDHYFLTDPREFIYEFYPLQEEWQLL 538
            .||..:....||.::             :||:.   ::|::.||||.|..||.:.:|.|..:|||
Frog   220 SAWHLLDSTMGAGYI-------------DDSINKFTFQYNEFYFLTHPALFIEDHFPEQMHYQLL 271

  Fly   539 KRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATVRIAM---------PTDMQ-- 592
            :.|::.::||.....||.|:..||..:.....|:.......:.|:..:.         .|:|.
Frog   272 ESPLSQKQFEENVQHRSHFYTLGLGSSHPHTSAIETVKGKASVTIERSQHIKFIITLNETEMPGL 336

  Fly   593 -------------------------------------------SCLIFHYNLKF----------- 603
                                                       .|...:.:||.
Frog   337 ITLTKHGTIFDVYPQKPGQHLLQIFAKRPGSDKAYHLVLDHIIDCRTVNNSLKIPKSLSNPVGPS 401

  Fly   604 ----------------------------YDSDEELSYDGVSLKRFVMQSVIGNI--------VAF 632
                                        :|.|..:.... :||...:::::.::        |.|
Frog   402 WISEKAGLIQPSHVDPVIHTEDGHCTIGFDLDRPMKLTS-NLKSDEVKNILNHVIQKRQKHKVEF 465

  Fly   633 RVHAPCSGAFLLDIFANAVTPQEYLTGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKA 697
            :||.|.:|:::|.||:.:             |..:|.:.|.|...:....|.|.......||...
Frog   466 QVHLPQAGSYVLQIFSGS-------------FGYICNYLITCSNTKVKCNPFPAALLNPVGPNPD 517

  Fly   698 TRLFGLIPITHQDPLIFAGRSLD----LQFRMSRPLTDFMATLHKNGIEEKKLAK-YVTHSTLDD 757
            |...|:.|.:|.||:|   .|.|    :.|.:.:.| ...:.|..|.:  |.|.: ::...:..:
Frog   518 TEKLGIHPSSHPDPVI---NSKDGCCNISFALDKVL-HITSYLKYNDV--KPLVRNHIIQKSQKN 576

  Fly   758 IVTFIINFPEEGQYGLDIYTRELGGPQHHHHHNNNNSSSSSGEKHLLTHCCKYLINSSKRN 818
            .|||.:..|:.|.|.|.|:    ||              |:|      :.|.||:..|..|
Frog   577 NVTFDVRLPQAGSYVLQIF----GG--------------STG------YICNYLLICSNPN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863
		TGc	418..486	CDD:214673	19/75 (25%)
LOC101730654	XP_012826884.2	CYK3	<129..>305	CDD:227604	56/201 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398889at33208
OrthoFinder	1	1.000	-	-		FOG0003908
OrthoInspector	1	1.000	-	-		otm47661
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010