DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hil and LOC101730218

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_004917894.1	Gene:	LOC101730218 / 101730218	-ID:	-	Length:	1133	Species:	Xenopus tropicalis

Alignment Length:	729	Identity:	164/729 - (22%)
Similarity:	262/729 - (35%)	Gaps:	213/729 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 NILTMRHEQQKED----LEKNMTLRRSKKKESITRKMLEHERYETAALVDRQSSEMLELISARRS 305
            ::|.:.|.|.|::    .|..:.||::.|  :..:|  .|...:..:..:.|.|.:...|..:.|
Frog    13 DLLLIVHSQDKQNGGDKSEDPVPLRQAVK--AAPKK--PHASGQIISSYESQESHVRVEIRPKTS 73

  Fly   306 EYMQSESIFLDDEFSEGAVPVEYPLNA----PIPAPPAV-------SKFQIYTDPI---EFEDVD 356
            :..     .|:...:.| .|| .|.|.    |.|.|.|.       .|..:.:.|:   .||.:|
Frog    74 KPQ-----VLNRPTATG-TPV-LPNNGNSWDPTPQPSAKDFYAYPWDKSNLKSLPMNLKNFEKLD 131

  Fly   357 RIAISVAQEDQKTFTDLVRQLVGRCTTDIEKARTIFRWITVKNLNAMHFDDDL---------RGD 412
            ..:..|.:  ..|...||..|:....||:||.|.|:.||      ..|.:.||         .||
Frog   132 AYSAKVGK--ASTVGQLVSSLIRMARTDLEKVRAIWTWI------CHHIEYDLDGMEDKSKRSGD 188

  Fly   413 TPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPGVKFQDSRFRNSWNAVYVAG 477
            ....||.| |...|.|..||:.:||:||:.|:.|.|:||...|..|..| .....::||||::..
Frog   189 PNQTLLSG-KGACEGYAGLFENMCSHAGIQCLKIGGFSKGFCYTTGQTF-SGETNHAWNAVFLNK 251

  Fly   478 AWRFVQCNWGARHLVNAKEAPKQGRGKNDSLRYEYDDHYFLTDPREFIYEFYPLQEEWQLLKRPI 542
            .|..:...|||..          .....:|.::.|::.||||.|..||.|.:|..:.||||:.|:
Frog   252 RWHLLDTTWGAGF----------ANSSTNSFKFRYNEFYFLTHPALFIEEHFPDNQNWQLLQVPL 306

  Fly   543 TLREFENLPFVRSLFFRYGL-----------------HFADEGYGAVVF------TDDTGAATV- 583
            ::::||......|.|:..||                 .|:.||:...:|      |:..|..|:
Frog   307 SMKQFEGNLCRNSSFYNAGLTASYPETLQVETVNGKATFSIEGHSPALFSFTLNKTEKPGIMTLT 371

  Fly   584 RIAMPTDMQSCLIFHYNLKFYD---SDEELSYD-------------------------------- 613
            :..|..|:...:...:.|:.|.   :..:.|||
Frog   372 KNGMQLDVYPTVTGRHKLELYTKPFNTVKESYDKVVEYILHCGSVDTGFRIPKELDPIVGPSWLT 436

  Fly   614 ------------------------GVSL--------------------KRFVMQSVIGNIVAFRV 634
                                    |.:|                    .|:|:|::.||.|.|::
Frog   437 EMKGFLQHLCSDPIIYTQDGCCSVGFTLAKKAIVLATLHSDNIKPGYENRYVLQTLRGNRVEFKI 501

  Fly   635 HAPCSGAFLLDIFANAVTPQEYLTGEPMKFKSVCKFKICCEELQTVMVPLPDCASGEWGPTKATR 699
            |.|..|.:.|.|.:::         .|:.|:..|.:.:.|...:....|.|.......|||....
Frog   502 HLPQQGYYALKIHSSS---------GPVTFECFCNYLVVCTNAEVAWSPFPRQLQNPVGPTALME 557

  Fly   700 LFGLIPITHQDPLIF-AGRSLDLQFRMSR-------------PLTD------FMATLHKNGIEEK 744
            ..||:..:.:||:|: :|....|.|.:..             ||||      .|.|...|.:|.:
Frog   558 KKGLLQPSQRDPIIYTSGSHCSLSFTLKEGIKILTSLLFDETPLTDHGGKRLVMQTQKGNHVEIQ 622

  Fly   745 KLAKYVTHSTLDDIVTFIINFPEEGQYGLDIYTRELGGPQHHHHHNN-----NNSSSSSGEKHLL 804
                              |..|..|.|.|.|:......|....:.:|     :::.:.|.|..:|
Frog   623 ------------------IYLPHAGPYILQIFANSKISPTSFEYVSNYLICCSSTEAGSSEGLVL 669

  Fly   805 THCCKYLINSSKRN 818
            ........|...||
Frog   670 AQSTLNSANPVDRN 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863	5/23 (22%)
		TGc	418..486	CDD:214673	24/67 (36%)
LOC101730218	XP_004917894.1	Transglut_core	145..257	CDD:280085	41/119 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398889at33208
OrthoFinder	1	1.000	-	-		FOG0003908
OrthoInspector	1	1.000	-	-		otm47661
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010