DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hil and LOC100486532

DIOPT Version :9

Sequence 1:	NP_611493.2	Gene:	Hil / 37328	FlyBaseID:	FBgn0050147	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	XP_031751113.1	Gene:	LOC100486532 / 100486532	-ID:	-	Length:	832	Species:	Xenopus tropicalis

Alignment Length:	470	Identity:	122/470 - (25%)
Similarity:	194/470 - (41%)	Gaps:	93/470 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 IEFEDVDRIAISVAQEDQ---KTFTDLVRQLVGRCTTDIEKARTIFRWITVKNLNAMHFDDD--- 408
            :.|..:|...|:.:.::.   .:..:.||.:.......:||.|.|:.|:    .:.:.:|.:
Frog   179 VTFTHIDNHVINWSGQNNCQALSIQETVRGITAEARNHLEKIRAIWIWL----CHNIRYDVEGYL 239

  Fly   409 ------LRGDTPMGLLRGIKYGTESYHVLFKRLCSYAGLHCVVIKGYSKSAGYQPGVKFQDSRFR 467
                  .|.:..:.|.:|:..|   |..|||.:|...|:.|..|.|||::..|..|:.|..::..
Frog   240 GFSQKVYRPEDVLALGKGVCSG---YAGLFKEMCREIGIGCKEISGYSRTTEYSDGLSFHRTKSN 301

  Fly   468 NSWNAVYVAGAWRFVQCNWGARHLVNAKE---APKQGRGKNDSLRYEYDDHYFLTDPREFIYEFY 529
            :.||||.:...|..:...||| ..|:.:|   .|            .|||.:|||||.:||...:
Frog   302 HMWNAVQLDTDWHLLDACWGA-GTVDLQEKIFIP------------SYDDFFFLTDPEDFIETHW 353

  Fly   530 PLQEEWQLLKRPITLREFENLPFVRSLFFRYGLHFADEGYGAVVFTDDTGAATVRIAM----PTD 590
            |.:..||||:..:..:|||...|..|.|||..|...    ...||...|....|::::    ||:
Frog   354 PDEATWQLLESVVPFQEFEQKIFKTSEFFRLHLFIV----SPKVFYLQTDQGEVKVSLGCLYPTE 414

  Fly   591 MQSCLIFHYNLKFYD-SDEELSYDGVSLKRFVMQSVIGNIVAFRVHAPCSGAFLLDIFANAVTPQ 654
                    ::.|.|. |::|.|....:.....||.   :.|..||..|..|.|.|.|||
Frog   415 --------FSYKIYKLSNKERSCVEKTHGIMTMQP---SGVTLRVVPPTDGLFELMIFA------ 462

  Fly   655 EYLTGEPM----KFKSVCKFKICCEELQTVMVPLPDCASG-------EWGPTKATRLFGLIPITH 708
                 :||    .::.||.:.|.|.|.:        |:.|       .||..:....||::....
Frog   463 -----KPMDSTGSYRWVCSYHIDCPESK--------CSQGLPHNPFHFWGLHQRAIDFGVLGCNC 514

  Fly   709 QDPLIFA-GRSLDLQFRMSRPLTDFMATLHKNGIEEKKLAK---YVTHSTLDDIVTFIINFPEEG 769
            ...|:.| |.|::|.|:.||||.......|   :|..|...   :|:|.....:...:: .|..|
Frog   515 AGDLVVADGGSVNLTFQTSRPLLAMYELAH---VELSKTLSTRCFVSHIEESQLSCQLL-LPFRG 575

  Fly   770 QYGLDIYTRELGGPQ 784
            .|.|.::.:.|.|.|
Frog   576 YYRLSLFVKNLSGDQ 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hil	NP_611493.2	LIM_Ltd-1	11..70	CDD:188827
		BAR	<147..>265	CDD:299863
		TGc	418..486	CDD:214673	21/67 (31%)
LOC100486532	XP_031751113.1	FeoC	58..118	CDD:419903
LOC100486532	XP_031751113.1	CYK3	<196..>390	CDD:227604	61/217 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D398889at33208
OrthoFinder	1	1.000	-	-		FOG0003908
OrthoInspector	1	1.000	-	-		otm47661
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3261
SonicParanoid	1	1.000	-	-		X3209
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950