Protein Alignment lms and SHOX

DIOPT Version :10

• Sequence 1: NP_611491.2
• Gene: lms / 37322
• FlyBaseID: FBgn0034520
• Length: 378
• Species: Drosophila melanogaster
• Sequence 2: NP_000442.1
• Gene: SHOX / 6473
• HGNCID: 10853
• Length: 292
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 66/274 - (24%)
• Similarity: 103/274 - (37%)
• Gaps: 86/274 - (31%)

  Fly    28 STSFEDSVQDESGRGG----------------NCLGASRASSPATSSCLD--------------D 62
            |.||:...:|.:|.||                :.|..||....:.||..|              |
Human     9 SKSFDQKSKDGNGGGGGGGGKKDSITYREVLESGLARSRELGTSDSSLQDITEGGGHCPVHLFKD 73

  Fly    63 NMDDGKSDI--------------------DLASDDGNGLGDDRKKRPRTAFSAAQIKALETEFER 107
            ::|:.|..:                    |:.|:|.:|....:::|.||.|:..|:..||..|:.
Human    74 HVDNDKEKLKEFGTARVAEGIYECKEKREDVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDE 138

  Fly   108 GKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKWKRK----YTSDVETLASHYYA-----QLGIG 163
            ..|.....|..|:::|.|:|.::::||||||.|.:::    :...:...|:|..|     .:.:|
Human   139 THYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMG 203

  Fly   164 GLARPMVVGDRLWLFSQTPTGPTPIQSIMLNGSGSAAPMASATTATGSP--MRPYATSGGMPP-- 224
            .|..|         |.|...      .:.|.|...|.|......|..:|  |.|       ||
Human   204 ALRMP---------FQQVQA------QLQLEGVAHAHPHLHPHLAAHAPYLMFP-------PPPF 246

  Fly   225 -LPGPSVMESARNA 237
             ||..|:.|||..|
Human   247 GLPIASLAESASAA 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lms	NP_611491.2	Cnd2	33..>106	CDD:450400	24/122 (20%)
		Homeodomain	87..143	CDD:459649	21/55 (38%)
SHOX	NP_000442.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..119		4/18 (22%)
		Homeodomain	118..174	CDD:459649	21/55 (38%)
		SH3-binding. /evidence=ECO:0000255	242..249		3/13 (23%)
		OAR	272..288	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	274..287