Protein Alignment Cpr57A and Notch1

DIOPT Version :9

• Sequence 1: NP_001137721.1
• Gene: Cpr57A / 37319
• FlyBaseID: FBgn0034517
• Length: 184
• Species: Drosophila melanogaster
• Sequence 2: NP_032740.3
• Gene: Notch1 / 18128
• MGIID: 97363
• Length: 2531
• Species: Mus musculus
• Alignment Length: 93
• Identity: 19/93 - (20%)
• Similarity: 36/93 - (38%)
• Gaps: 13/93 - (13%)

  Fly    49 HTEVSDGSGVIRGAFSYVDPKNQVRTVQYVADEHGFHPQLSHKLEDSAAVQAAKQ---------- 103
            |.:|:....:.:.|..:....|.| ....|..::|.:..:.:..|::....||::
Mouse  2008 HADVNAVDDLGKSALHWAAAVNNV-DAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLL 2071

  Fly   104 RHFAAYNRIAQEHANHTPGQVALANAPH 131
            .|||  ||...:|.:..|..:|.....|
Mouse  2072 DHFA--NRDITDHMDRLPRDIAQERMHH 2097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpr57A	NP_001137721.1	Chitin_bind_4	32..84	CDD:278791	6/34 (18%)
Notch1	NP_032740.3	EGF_CA	142..175	CDD:238011
		EGF_CA	178..216	CDD:238011
		EGF_CA	257..293	CDD:238011
		EGF_CA	295..332	CDD:238011
		EGF_CA	335..370	CDD:238011
		EGF_CA	412..450	CDD:238011
		Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008	420..421
		Interaction with DLL4. /evidence=ECO:0000250|UniProtKB:Q07008	448..452
		EGF_CA	452..488	CDD:238011
		EGF_CA	490..526	CDD:238011
		EGF_CA	528..564	CDD:238011
		EGF_CA	566..601	CDD:238011
		EGF_CA	603..639	CDD:238011
		EGF_CA	641..675	CDD:238011
		EGF_CA	678..713	CDD:238011
		EGF_CA	717..750	CDD:238011
		EGF_CA	755..789	CDD:238011
		EGF_CA	791..827	CDD:238011
		EGF_CA	869..905	CDD:238011
		EGF_CA	907..943	CDD:238011
		EGF_CA	945..981	CDD:238011
		EGF_CA	988..1019	CDD:238011
		EGF_CA	1021..1057	CDD:238011
		EGF_CA	1146..1180	CDD:238011
		EGF_CA	1184..1219	CDD:238011
		EGF_CA	1221..1265	CDD:238011
		EGF_CA	1267..1305	CDD:238011
		NL	1442..1479	CDD:197463
		LNR 1	1449..1489
		Notch	1487..1522	CDD:278494
		LNR 2	1490..1531
		Notch	1525..1561	CDD:278494
		LNR 3	1532..1571
		NOD	1567..1618	CDD:284282
		NODP	1662..1719	CDD:284987
		Interaction with PSEN1. /evidence=ECO:0000250|UniProtKB:P46531	1718..1750
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1770..1798
		Ank_2	<1863..1948	CDD:289560
		ANK repeat	1870..1915	CDD:293786
		ANK	1912..2024	CDD:238125	3/15 (20%)
		ANK repeat	1917..1948	CDD:293786
		ANK 1	1917..1946
		Ank_2	1922..2015	CDD:289560	2/6 (33%)
		HIF1AN-binding	1937..1945
		ANK repeat	1950..1981	CDD:293786
		ANK 2	1950..1980
		ANK	1979..2103	CDD:238125	19/93 (20%)
		ANK repeat	1984..2015	CDD:293786	2/6 (33%)
		ANK 3	1984..2013		2/4 (50%)
		Ank_2	1989..2081	CDD:289560	15/75 (20%)
		HIF1AN-binding	2004..2012		1/3 (33%)
		ANK repeat	2017..2081	CDD:293786	13/66 (20%)
		ANK 4	2017..2046		5/29 (17%)
		ANK 5	2050..2079		8/30 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2140..2185
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2382..2428
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2440..2531
		DUF3454	2454..2516	CDD:288764

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.924933	Normalized mean entropy	S1795
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950