DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VIII and Nphs1

DIOPT Version :9

Sequence 1:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	883	Identity:	179/883 - (20%)
Similarity:	293/883 - (33%)	Gaps:	313/883 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLVLSALNGPAAAASRVRVSSSTTMTRNIEEENALLLLLAGPPV-----LSESIM--GTVGRLPC 72
            |||....| ||.|..   :.:|.||.         :|...||||     |:|..:  |....|||
Mouse   228 LLVCEGSN-PALATP---IKASFTMN---------ILFPPGPPVIDWPGLNEGHVRAGENLELPC 279

  Fly    73 ---NVTPPIYEDRVALVIWYKVGLKTPIYSVDTRDSNFAQGTHWSDETYRERLSFHVEGRAGTLT 134
               ...||      |.:.|.|.|  .|:        :.|.||.            |.:..|.::.
Mouse   280 IARGGNPP------ATLQWLKNG--KPV--------SIAWGTE------------HAQAVAHSVL 316

  Fly   135 IKSTTEDDTGEYRCRVDFQ-----KSPTRNSKVNLTVIIPPESVIILDSKGVTIEDHTLGPYNEG 194
            :.:...:|.|   .|:..|     .:.|:...:.|.|..||.:|.||.|..          .:|.
Mouse   317 VMTVRPEDHG---ARLSCQSYNSVSAETQERSITLQVTFPPSAVTILGSTS----------QSEN 368

  Fly   195 SGINITCVAIGGRPQPRVTWLHGNTVYKNASVGQPLSERRVGNTLSLARL----ERRNLHMQLTC 255
            ..:.:.|:....||:..:.|..|..  :.....:.:.:...|..:|::.|    :|.:..:.|||
Mouse   369 KNVTLCCLTKSSRPRVLLRWWLGGR--QLLPTDETVMDGLHGGHISMSNLTLLVKREDNGLSLTC 431

  Fly   256 RAENNNLTTPII-SSVVLDMNLRPLIVKLQG--ENRALSAGNSYQLSCVVIGARPAPTITWWKGS 317
            .|.::..:.... .|:.|::......:.::|  |.:::..|...:|.|:.||..|.|::||.|.|
Mouse   432 EAFSDAFSKETFKKSLTLNVKYPAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDS 496

  Fly   318 TPMKNTHEIATPD----GNLTTSVLTFTPTI-------DDRGKFLSCRAEQ-------------- 357
            .|:.:..:...|.    |::..|..||:..:       |:..|| ||:|.|
Mouse   497 RPVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKF-SCKAGQLSASTQLVVQFPPT 560

  Fly   358 ---SMIPESGMEDGWKLDIYHI-----PVVSLEL--------------------GTNSLNS---- 390
               .:...|.:..|..|::..:     |.|:|.|                    |:.:..|
Mouse   561 NLTILANSSALRPGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSAASRSVFLR 625

  Fly   391 -----------------TLREGIDVFFECN----------------------------IKSNPWI 410
                             .|||.:..|:..|                            :.:||..
Mouse   626 VSSRDHGHRVTCRAHSEALRETVSSFYRLNVLYPPEFLGEQVRAVTVVEQGQALLPVSVSANPAP 690

  Fly   411 YEVSWRHNGKILTNNPAEG---IAVSNQSLVLQNASRARSGIYTCVGSNREGDGESNPVQLDIRF 472
            ...:|...|..|  :||.|   ..:|..:|.|.|.:||..|.|.....|.||..|: .::||:.:
Mouse   691 EAFNWTFRGYRL--SPAGGPRHRILSGGALQLWNVTRADDGFYQLHCQNSEGTAEA-LLKLDVHY 752

  Fly   473 APVCRP-RQRLSYSSGRHETVKVACEIDANP-AEATYVW------------------------KF 511
            ||..|. :.....:.|  .:|.:.|.:|||| ....:.|                        :.
Mouse   753 APTIRALKDPTEVNVG--GSVDIVCTVDANPILPEMFSWERLGEDEEELNLDDMEKMSKGSTGRL 815

  Fly   512 NATQGETVDIPASQVAVDRG----------------RSIAHYTPMTE------------------ 542
            ...|.:.....|.|..||.|                ..:.|.||:|:
Mouse   816 RIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTPLTKVAAAGDSTSSATLHCRAR 880

  Fly   543 ----------------------------------------------NDYGTLLCWATNEIGDQSE 561
                                                          .||....|.|||.:|  |:
Mouse   881 GVPNIDFTWTKNGVPLDLQDPRYTEHKYHQGVVHSSLLTIANVSAAQDYALFKCTATNALG--SD 943

  Fly   562 PCVYTIFPAGEPDPLLNCTVLNQTSTGFQIECIEGFNGGLQQDFIME---------VYMNGTTRH 617
            .....:.....|||.|...|::.:.....:|...||:|||.|.|.:.         :||:
Mouse   944 HTNIQLVSISRPDPPLGLKVVSVSPHSVGLEWKPGFDGGLPQRFQIRYEALESPGFLYMD----- 1003

  Fly   618 PKISKSKRPYFEVSGLVPGMGYNVFLIANNSKGRSNAT 655
              :..::...|.::||.|...|.::|:|:|:.|.|..|
Mouse  1004 --VLPAQATTFTLTGLKPSTRYRIWLLASNALGDSGLT 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	28/125 (22%)
		IG_like	60..166	CDD:214653	23/115 (20%)
		Ig	182..266	CDD:299845	14/87 (16%)
		Ig	296..373	CDD:299845	26/104 (25%)
		IG_like	389..464	CDD:214653	26/126 (21%)
		IGc2	394..459	CDD:197706	20/95 (21%)
		Ig_3	490..554	CDD:290638	21/168 (13%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845
		IG_like	52..127	CDD:214653
		C2-set_2	155..242	CDD:285423	7/17 (41%)
		Ig	254..332	CDD:299845	25/108 (23%)
		IG_like	268..350	CDD:214653	22/112 (20%)
		C2-set_2	358..440	CDD:285423	17/93 (18%)
		Ig	459..544	CDD:299845	24/85 (28%)
		I-set	460..555	CDD:254352	26/95 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		7/24 (29%)
		Ig	563..646	CDD:299845	10/82 (12%)
		IG_like	670..750	CDD:214653	21/82 (26%)
		Ig	676..750	CDD:299845	21/76 (28%)
		Ig_3	753..834	CDD:290638	15/82 (18%)
		IG_like	762..848	CDD:214653	14/87 (16%)
		Ig	848..956	CDD:299845	12/109 (11%)
		IG_like	859..949	CDD:214653	10/91 (11%)
		fn3	956..1039	CDD:278470	24/89 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810