DRSC/TRiP Functional Genomics Resources

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Protein Alignment side-VIII and NPHS1

DIOPT Version :10

Sequence 1:NP_001097382.2 Gene:side-VIII / 37310 FlyBaseID:FBgn0086604 Length:1201 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:985 Identity:206/985 - (20%)
Similarity:316/985 - (32%) Gaps:348/985 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SSRSLFLPLCLLVLSALNGPAAAASRVRVSSSTTMTRNIEEENALLLLLAGPPV-----LSESIM 64
            ||.:..|.:|.....||..|..|:..|.|                 |...||||     |.|..:
Human   208 SSDNRQLLVCEASSPALEAPIKASFTVNV-----------------LFPPGPPVIEWPGLDEGHV 255

  Fly    65 --GTVGRLPC---NVTPPIYEDRVALVIWYKVGLKTPIYSVDTRDSNFAQGTHWSDETYRERLSF 124
              |....|||   ...|      :|.:.|.|.|  .|:            .|.|..|        
Human   256 RAGQSLELPCVARGGNP------LATLQWLKNG--QPV------------STAWGTE-------- 292

  Fly   125 HVEGRAGTLTIKSTTEDDTG-EYRCRVDFQKSP-TRNSKVNLTVIIPPESVIILDSKGVTIEDHT 187
            |.:..|.::.:.:...:|.| :..|......|. |:...:.|.|..||.::|||.|...|     
Human   293 HTQAVARSVLVMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIILGSASQT----- 352

  Fly   188 LGPYNEGSGINITCVAIGGRPQPRVTW-----------------LHGNTVYKNASVGQPLSERRV 235
                 |...:.::||:...||:..:.|                 |||..:             .:
Human   353 -----ENKNVTLSCVSKSSRPRVLLRWWLGWRQLLPMEETVMDGLHGGHI-------------SM 399

  Fly   236 GNTLSLARLERRNLHMQLTCRAENNNLTTPII-SSVVLDMNLRPLIVKLQG--ENRALSAGNSYQ 297
            .|...|||.|...|  .|||.|.:...|.... .|::|::......:.::|  |.:.|.||...:
Human   400 SNLTFLARREDNGL--TLTCEAFSEAFTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVR 462

  Fly   298 LSCVVIGARPAPTITWWK-------------------------GST----------PMKNTHEIA 327
            |.|:.||..|.|::.|:|                         |||          |..|..:..
Human   463 LVCLAIGGNPEPSLMWYKDSRTVTESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFT 527

  Fly   328 TPDGNLTTS---VLTFTPT---------------------------------------------- 343
            ...|.|:.|   .:.|.||                                              
Human   528 CKAGQLSASTQLAVQFPPTNVTILANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEGVAA 592

  Fly   344 ---------------------IDDRGKFLSCRAEQSMIPESGMEDGWKLDIYHIPVVSLELGTNS 387
                                 ..|.|:.::|||..:.:.|: :...::|::.:.|..   ||...
Human   593 PPRRAPFKGSAAARSVLLQVSSRDHGQRVTCRAHSAELRET-VSSFYRLNVLYRPEF---LGEQV 653

  Fly   388 LNSTLREGIDVFFECNIKSNPWIYEVSWRHNGKILTNNPAEG---IAVSNQSLVLQNASRARSGI 449
            |..|..|..:.....::.:||.....:|...|..|  :||.|   ..:|:.:|.|.|.:||..|:
Human   654 LVVTAVEQGEALLPVSVSANPAPEAFNWTFRGYRL--SPAGGPRHRILSSGALHLWNVTRADDGL 716

  Fly   450 YTCVGSNREGDGESNPVQLDIRFAPVCRPRQ-RLSYSSGRHETVKVACEIDANP-AEATYVWK-- 510
            |.....|.||..|:. ::||:.:||..|..| ....:.|  .:|.:.|.:|||| ....:.|:  
Human   717 YQLHCQNSEGTAEAR-LRLDVHYAPTIRALQDPTEVNVG--GSVDIVCTVDANPILPGMFNWERL 778

  Fly   511 ------------FNATQGET----------VDIPASQVAVDRG----------------RSIAHY 537
                        ...::|.|          ....|.|..||.|                ..:.|.
Human   779 GEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGVAPPARRLLRLVVRFAPQVEHP 843

  Fly   538 TPMTE------------------------------------------------------------ 542
            ||:|:                                                            
Human   844 TPLTKVAAAGDSTSSATLHCRARGVPNIVFTWTKNGVPLDLQDPRYTEHTYHQGGVHSSLLTIAN 908

  Fly   543 ----NDYGTLLCWATNEIG-DQSEPCVYTIFPAGEPDPLLNCTVLNQTSTGFQIECIEGFNGGLQ 602
                .||....|.|||.:| ||:...:.:|   ..|||.....|::.|.....:|...||:|||.
Human   909 VSAAQDYALFTCTATNALGSDQTNIQLVSI---SRPDPPSGLKVVSLTPHSVGLEWKPGFDGGLP 970

  Fly   603 QDFIMEVYMNGTT--RHPKISKSKRPYFEVSGLVPGMGYNVFLIANNSKGRS----NATILQVYT 661
            |.|.:.....||.  .:..:...:...|.::||.|...|.|:|:|:|:.|.|    ..|.|.:.|
Human   971 QRFCIRYEALGTPGFHYVDVVPPQATTFTLTGLQPSTRYRVWLLASNALGDSGLADKGTQLPITT 1035

  Fly   662 --LKDPEKQTVKITFTKSFQG-----LRPA-YTKTKATATTTSDCVCD---EDEFLNLGKGISHD 715
              |..|..:......|:...|     |.|. :........:.:.||..   :.....|.:|||  
Human  1036 PGLHQPSGEPEDQLPTEPPSGPSGLPLLPVLFALGGLLLLSNASCVGGVLWQRRLRRLAEGIS-- 1098

  Fly   716 EGTDADQQED 725
            |.|:|..:||
Human  1099 EKTEAGSEED 1108

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
side-VIIINP_001097382.2 IG_like 60..166 CDD:214653 22/112 (20%)
Ig strand B 69..72 CDD:409353 1/2 (50%)
Ig strand C 85..89 CDD:409353 0/3 (0%)
Ig strand E 131..135 CDD:409353 0/3 (0%)
Ig strand F 145..150 CDD:409353 1/4 (25%)
Ig 189..273 CDD:472250 21/101 (21%)
Ig strand B 197..201 CDD:409353 0/3 (0%)
Ig strand C 211..215 CDD:409353 1/20 (5%)
Ig strand E 237..241 CDD:409353 1/3 (33%)
Ig strand F 252..257 CDD:409353 3/4 (75%)
Ig strand G 267..270 CDD:409353 0/3 (0%)
Ig 290..373 CDD:472250 29/187 (16%)
Ig strand B 296..300 CDD:409353 1/3 (33%)
Ig strand C 310..314 CDD:409353 0/3 (0%)
Ig strand F 350..355 CDD:409353 1/4 (25%)
Ig strand G 366..369 CDD:409353 0/2 (0%)
Ig_3 377..456 CDD:464046 22/81 (27%)
NPHS1NP_004637.1 V-set 38..119 CDD:462230
C2-set_2 141..228 CDD:400489 6/19 (32%)
Ig strand B 156..160 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 200..204 CDD:409353
Ig strand F 214..219 CDD:409353 2/4 (50%)
Ig strand G 229..232 CDD:409353 1/2 (50%)
Ig 237..336 CDD:472250 28/126 (22%)
Ig strand B 261..265 CDD:409353 1/3 (33%)
Ig strand C 275..279 CDD:409353 0/3 (0%)
Ig strand E 300..304 CDD:409353 0/3 (0%)
Ig strand F 314..319 CDD:409353 1/4 (25%)
Ig strand G 332..335 CDD:409353 0/2 (0%)
Ig 345..424 CDD:472250 23/103 (22%)
Ig strand B 357..361 CDD:409353 0/3 (0%)
Ig strand C 371..375 CDD:409353 0/3 (0%)
Ig strand E 400..404 CDD:409353 1/3 (33%)
Ig strand F 414..419 CDD:409353 3/4 (75%)
Ig strand G 430..433 CDD:409353 0/2 (0%)
Ig 446..541 CDD:472250 21/94 (22%)
Ig strand B 461..465 CDD:409353 1/3 (33%)
Ig strand C 475..479 CDD:409353 0/3 (0%)
Ig strand E 510..515 CDD:409353 0/4 (0%)
Ig strand F 525..530 CDD:409353 0/4 (0%)
Ig 549..632 CDD:472250 5/82 (6%)
Ig strand B 563..567 CDD:409353 0/3 (0%)
Ig strand C 577..581 CDD:409353 0/3 (0%)
Ig strand E 606..610 CDD:409353 0/3 (0%)
Ig strand F 620..625 CDD:409353 1/4 (25%)
Ig strand G 635..638 CDD:409353 0/2 (0%)
Ig 646..736 CDD:472250 27/95 (28%)
Ig strand B 664..668 CDD:409353 0/3 (0%)
Ig strand C 678..682 CDD:409353 0/3 (0%)
Ig strand E 702..706 CDD:409353 1/3 (33%)
Ig strand F 716..721 CDD:409353 1/4 (25%)
Ig strand G 729..732 CDD:409353 1/3 (33%)
Ig_3 740..820 CDD:464046 16/81 (20%)
IgC1_hNephrin_like 834..942 CDD:143250 14/110 (13%)
putative Ig strand A 839..844 CDD:143250 1/4 (25%)
putative Ig strand B 859..866 CDD:143250 0/6 (0%)
putative Ig strand C 870..876 CDD:143250 0/5 (0%)
putative Ig strand C' 879..881 CDD:143250 0/1 (0%)
putative Ig strand D 888..891 CDD:143250 0/2 (0%)
putative Ig strand E 898..906 CDD:143250 0/7 (0%)
putative Ig strand F 917..924 CDD:143250 2/6 (33%)
putative Ig strand G 939..942 CDD:143250 0/2 (0%)
FN3 941..1022 CDD:238020 25/80 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137 5/10 (50%)
Binds to NPHS2 1160..1241
Blue background indicates that the domain is not in the aligned region.

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