DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VIII and nrm

DIOPT Version :9

Sequence 1:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster

Alignment Length:	1344	Identity:	280/1344 - (20%)
Similarity:	469/1344 - (34%)	Gaps:	362/1344 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SRSLFLPLCLLVLSALNGPAAAASRVRVSSSTTMTRNIEEENALLLLLAGPPVLSESIMGTVGRL 70
            |.||.|.|||.::.              ||:..:...|.::.            |:|::     |
  Fly    26 SLSLVLVLCLALVD--------------SSTAQVDTTISQQE------------SQSVV-----L 59

  Fly    71 PCNVTPPIYED---RVALVIWYKVGLKTPIYSVDTRDSNFAQGTHWSDETYRERLSFHVEGRAGT 132
            ||    |:..:   ::..:.|:|...:  |.::...|||...    .::.:.||::  ||.....
  Fly    60 PC----PVDAEKCGKLHSLNWFKGDDR--IAAMLLGDSNVTS----VNKEFDERVT--VEQNPYR 112

  Fly   133 LTIKSTTEDDTGEYRCRVDF----QKSPTRNS-KVNLTVIIPPESVIILDSKGVTIED-HTLGPY 191
            |.||.....|...|.|...|    :.....|. ::.|.|::||..|:|||:||..|:: ..:||.
  Fly   113 LVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPM 177

  Fly   192 NEGSGINITCVAIGGRPQPRVTWLHGNTVYKNASVGQPLSERRVGNTLSLA-RLERRNLHMQLTC 255
            .|...:..||.....||||.|:|..|.......|....|.:....:||.|. .|.|.:|...:.|
  Fly   178 QERQSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIEC 242

  Fly   256 RAENNNLTTPIISSVVLDMNLRPLIVKLQGENRALSAGNSYQLSCVVIGARPAPTITWWKGSTPM 320
            |.::..:....::...:|:.:||..:.:.|.......|:...|:|.:.|||||..:||:..:|.:
  Fly   243 RVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWYNTTTII 307

  Fly   321 KN---------THEIATPDGNL-TTSVLTFTPTIDDRGKFLSCRAEQSMIP---ESGMEDGWKLD 372
            .:         :..:...||.. |.|.|.|..|..:..:...|.||..::.   |..:.....|:
  Fly   308 SSGENEITEVRSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLE 372

  Fly   373 IYHIPVVSLELGTNSLNSTLREGIDVFFECNIKSNP-WIYEVSWRHNGKILTNNPA---EGIAVS 433
            :.:.|||.:.....:.|::    ..|...|...:|| .:.:|.|..|..::..|..   :|....
  Fly   373 VLYPPVVKVSPSAITANTS----EIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSE 433

  Fly   434 NQSLVLQNASRARSGIYTCVGSNREGDGESN-PVQLDIRFAPVCR----PRQRLSYSSGRHETVK 493
            |.:||:::..:...|.|:|..||..|.|.|: .:.||:::||...    |...:..|.  ...|.
  Fly   434 NVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESD--ESNVT 496

  Fly   494 VACEI-DANPAEATYV-WKFNA-----------TQGETVDIPASQVAVDR-GRSIAH-YTPMTEN 543
            :.|.: ||||:..|.| |..|:           |:.:...|..|::.::. ||...: |:....|
  Fly   497 LFCNVLDANPSVLTKVRWYANSTLLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFN 561

  Fly   544 DYGTLLCWATNEIGDQSE-----------PCVYTIFP---AGEPDPLLNCTVLNQTSTGF----Q 590
            ..|    |     |.:||           |...:.||   ..:.....:|:|   ...||    :
  Fly   562 AAG----W-----GPRSEDKELLVHYEPGPAALSHFPLVAVKKKSVTFSCSV---DDPGFPESNR 614

  Fly   591 IECIEGFNGGLQQDFIMEVYMNGTTRHPKISKSKRPYFEVSGLVPGMGYNVFLIANNSKGRSNAT 655
            ...:.|..|.| ||.:                :|....|..||.....|:.:......||.....
  Fly   615 FRWLRGGRGPL-QDIV----------------TKDWTVEPVGLDSRTNYSCYAYNEGGKGVMATV 662

  Fly   656 ILQVYTLKDPEKQTVKITFTKSFQGLRPAYT-----KTKATATTTSDCV--CDEDEFLNLGKGIS 713
            .|:|:.   |.      .|.|:.    |.||     ...||.|...:||  ||          ||
  Fly   663 NLEVHA---PP------FFIKNL----PPYTGILHSSPNATLTCRIECVPRCD----------IS 704

  Fly   714 -HDEGTDADQQE------DLSLAYAPVIEDIRPFLGIL----AGIVGSIFLVALIIVIVVRVRGS 767
             ..:|...::.:      :..:..:|...|....|.:|    .....|.|.:.
  Fly   705 WQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIE------------ 757

  Fly   768 SGRDRNNYSHPGSG--VGG-------------------------------VGGV----------- 788
              .|..|||...:|  |||                               .|.|
  Fly   758 --ADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANPEPS 820

  Fly   789 ------GGTTGNGSGMGGGGGGVGGTTANGN--GSLGLLASNNNGSLVIGTLGHNGGQSVQDMHR 845
                  ..|..||:.:      :..|..|.|  |:...||.|.:||.:..|:     ..||...|
  Fly   821 YKWIFKNETIANGNAL------IINTAMNRNDDGTYTCLAYNKHGSSIAKTV-----IKVQFKPR 874

  Fly   846 IGRETCHV-TSSLDSIDKNPDIIPQDGH--DLDDEWTTKGHGRTYATAAMAEQNAVITSGTY--- 904
                 |.: ...:|  |::..|....|:  :.|..|:.|....|.......::...:....|
  Fly   875 -----CEIERQEID--DQDTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQ 932

  Fly   905 -DH-LMPTYAVVDKKTAPPPGHGQYIQYNTLIPVSKMGAYANQQQQLQQQPQQKTELSYSELSAP 967
             |: :..||..|...|.   |:|.:.:    |.|::..|:        .|..:|..|..
  Fly   933 TDYAISRTYRCVANNTV---GYGPFCE----IEVAEQLAW--------WQLWEKNTLII------ 976

  Fly   968 LVSGPVG-VQRMAPYCSATLGRPGRQAELKRAEPNIYSQVNVMMDDEILADLQAATASGRSYVAG 1031
            ||:..:| :..:...|...:....|    :|.:....::|.:......|:|....:.:||
  Fly   977 LVAAILGLLLTVIVICCIIICICRR----RRRQDKYLTEVPINSIQSALSDQLDMSRAGR----- 1032

  Fly  1032 AVVDNVGGAPNLYVQGYATRIDLAHHPMPMYSTSPMFGTNSTITGVTMSHPSQLATFSPTPPP-- 1094
                      ||..|...|.|      :|..|:|...|:                  :|..||
  Fly  1033 ----------NLSTQDKCTAI------LPNPSSSRFIGS------------------APKSPPRW 1063

  Fly  1095 PIFTHSMVTTGDGLLQPVTCMGLVATSSAGASVPGPVPLAPQQQQQQQLTAANGG-----NGSIV 1154
            ||....|:.......:.:|...:....:...:      .....|...||:||..|     :|:|:
  Fly  1064 PIRPGVMLHVSSNTKENLTVNRMTVKPNVSGN------RGDMSQLSAQLSAALNGSRDNSDGTIL 1122

  Fly  1155 GMGMSLYG-SDVGKPQLLK-------TVPEEVHHQLNGEDILIA 1190
            ....::.| ::.....:|:       |||..:.:....|..:|:
  Fly  1123 TEISAVSGENEASNLSILEVTNRKKATVPSTIRNVSTAEGEIIS 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	25/118 (21%)
		IG_like	60..166	CDD:214653	25/113 (22%)
		Ig	182..266	CDD:299845	23/85 (27%)
		Ig	296..373	CDD:299845	22/89 (25%)
		IG_like	389..464	CDD:214653	20/78 (26%)
		IGc2	394..459	CDD:197706	17/68 (25%)
		Ig_3	490..554	CDD:290638	19/78 (24%)
nrm	NP_001246890.1	Ig	44..152	CDD:299845	26/136 (19%)
		Ig	176..248	CDD:299845	21/71 (30%)
		Ig	277..354	CDD:299845	20/76 (26%)
		IG_like	383..463	CDD:214653	20/83 (24%)
		Ig	394..463	CDD:143165	19/68 (28%)
		Ig_3	585..652	CDD:290638	16/86 (19%)
		Ig	685..>719	CDD:299845	10/43 (23%)
		IG_like	788..869	CDD:214653	15/91 (16%)
		Ig	<811..869	CDD:299845	13/68 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810