DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment side-VIII and kirre

DIOPT Version :9

Sequence 1:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_001245505.1	Gene:	kirre / 31292	FlyBaseID:	FBgn0028369	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	1051	Identity:	228/1051 - (21%)
Similarity:	358/1051 - (34%)	Gaps:	339/1051 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSRSLFLPLCL-LVLSALNGPAAAASRVR-------------VSSSTTMTRNIEEENALLLL--- 52
            |||.|.|||.| |:|:.|..|.|..::.:             .|||::.:.:....:|....
  Fly     6 SSRLLVLPLILVLILTLLLQPIAVHAKSKKNKSSQSSHHGDSSSSSSSSSSSSGSSSAAASSAND 70

  Fly    53 -------------LAGPPVLSESIMGTVGRLPCNVTPPIYEDRVALVIWYKVGLKTPIYSVDTRD 104
                         .|..|....:::|:...|||.|.     ::|..:.|             |:|
  Fly    71 ESKPKGGDNGGQHFAMEPQDQTAVVGSRVTLPCRVM-----EKVGALQW-------------TKD 117

  Fly   105 SNFAQGTHWSDETYRERLSFHVEGRAG--TLTIKSTTEDDTGEYRCRVDFQKSP-----TRNSKV 162
             :|..|.|.:...: ||.|.......|  :|.|.....||..:|:|:|.  ..|     .|:...
  Fly   118 -DFGLGQHRNLSGF-ERYSMVGSDEEGDFSLDIYPLMLDDDAKYQCQVG--PGPQGEQGIRSRFA 178

  Fly   163 NLTVIIPPESVIILDSKG---VTIEDHTLGPYNEGSGINITCVAIGGRPQPRVTWLH--GNTVYK 222
            .|||::|||:..|  ::|   ||.||..         |.:.||:.||:|...:||:.  ||.:.|
  Fly   179 KLTVLVPPEAPKI--TQGDYLVTTEDRE---------IELECVSQGGKPAAEITWIDGLGNVLTK 232

  Fly   223 NAS-VGQPLSERRVGNTLSLARLERRNLH--MQLTCRAENNNLTTPIISSVVLDMNLRP-LIVKL 283
            ... |.:||::.|.....|:.:|..:..|  ...||:|:|....|...:.::|::...| :||.:
  Fly   233 GIEYVKEPLADSRRITARSILKLAPKKEHHNTTFTCQAQNTADRTYRSAKLLLEVKYAPKVIVSV 297

  Fly   284 QGENRALSAGNSYQLSCVVIGARPAPTITWWKGSTPMKNTHEIA--------TPDGNLTTSVLTF 340
            .|  .||:.|...:.:.|::..:..            .|.||::        ...|:.||.::..
  Fly   298 VG--GALAGGKIPEGAEVILSCQAD------------ANPHELSYRWFINDELMTGDFTTKMIIH 348

  Fly   341 TPTIDDRGKFLSC-------RAEQSMIPESGMEDGWKLDIYHIPV-----VSLELGTNSLNSTLR 393
            ..:.......:.|       ::|||.          ||||...||     ||:|...
  Fly   349 NVSRQYHDAIVKCEVVNAVGKSEQSK----------KLDISFGPVFRQRPVSVEADL-------- 395

  Fly   394 EGIDVFFECNIKSNPWIYEVSWRHNGKILTNNPAEGIAVSNQSLVLQNASRARSGIYTC---VGS 455
             |..|...|::..|| ..|:.|      ::.|..:.:.|:.: |.|:.:|.. :|.|.|   |..
  Fly   396 -GATVSMRCDVAGNP-EPEIEW------ISENSDQVVGVAAE-LKLKVSSET-AGRYFCKAVVNG 450

  Fly   456 NREGDGESNPVQLDIRFAPVCRPRQ-RLSYSSGRHETVKVACEIDANPAEATYVWKFNATQGETV 519
            ..|...|:.   |.::.||:....: :.....||   ||:.|...:.|.....:|.|   :|:.:
  Fly   451 FPEIGAEAT---LYVKRAPIITSHKVQFGGVGGR---VKIDCLAFSIPKAEHILWSF---EGKII 506

  Fly   520 DIPASQ-----------------VAVDRGRSIAHYTPMTENDYGTLLCWATNEIGDQS------- 560
            ::.::.                 ..:.|.....|        :|...|...|..|..|
  Fly   507 NMSSADPDIYIFEEHHLPEGVRAALIIRDSKATH--------FGKYNCTVMNSYGGDSLVITLLR 563

  Fly   561 EP--------------CVYTI-------------------FPAGE-PDPLLNCTVLNQ-----TS 586
            ||              ||..|                   .||.. |:.......||:     .|
  Fly   564 EPGNIPVLLVVMGSMFCVAIILMIVMIIIVYRKRRSRKKPMPADVIPEASRGGDKLNELKSELRS 628

  Fly   587 TGFQIECIEGFNGG----LQQDFIMEVYMNGTTRHPKISKSKRPYFEVSGLVPGMGYNVFLIANN 647
            ..:.:|..|....|    |.|..:.:|.|.|.|....::...:.....||...|..||......|
  Fly   629 KAYDVEYSEAGGDGLAINLTQSPMPDVQMKGATLGVPLAGPVKFDERFSGDFGGDRYNRQCHIKN 693

  Fly   648 SK------------------------------GRSNATIL---QVYTLKDPEKQTVKITFTKSFQ 679
            .|                              |...|.::   .|..||:              .
  Fly   694 LKNQQETAYKGSPQANGYAHYFEYALDYSPPGGEGAAVVVGSGGVGKLKN--------------G 744

  Fly   680 GLRPAYTKTKATATTTSDCVCDEDEFLNLGKGISHDEGTDAD-------QQEDLSLAY--APVIE 735
            |:..|.....|.||..             |.|..:..|....       ||...|..:  .|:::
  Fly   745 GMNSATLPHSAAATVN-------------GGGAGNGGGASLPRNQRHEIQQSQQSNGFLGQPLLQ 796

  Fly   736 DIRPFLGI---LAGIVGSIFLVALIIVIVVRVRGSSGRD------------RNNYSHPGSG---- 781
            :     ||   .:.|.|:.:|.....::......|:...            |:.::|..:|
  Fly   797 N-----GIDSRFSAIYGNPYLRTNSSLLPPLPPPSTANPAATPAPPPYHAARHGHAHHANGGLKH 856

  Fly   782 -VGG----VGGVGGTTGNGSGMGG----GGGGVG-GTTANGN---GSLGLLASNNN---GSLVIG 830
             |||    ...||....||.|.||    |||||| |..|.|:   .|..|.||:|.   ..|..|
  Fly   857 FVGGAVITTSPVGNVNINGGGGGGSTPSGGGGVGVGVAAGGSVSGSSSNLTASSNTLAATPLAGG 921

  Fly   831 TLGHNGGQSVQ 841
            .:| |.||..|
  Fly   922 GVG-NSGQCAQ 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	27/117 (23%)
		IG_like	60..166	CDD:214653	26/112 (23%)
		Ig	182..266	CDD:299845	26/88 (30%)
		Ig	296..373	CDD:299845	13/91 (14%)
		IG_like	389..464	CDD:214653	18/77 (23%)
		IGc2	394..459	CDD:197706	16/67 (24%)
		Ig_3	490..554	CDD:290638	11/80 (14%)
kirre	NP_001245505.1	Ig	87..183	CDD:299845	28/117 (24%)
		IG_like	88..182	CDD:214653	27/115 (23%)
		C2-set_2	189..279	CDD:285423	29/100 (29%)
		Ig_2	307..379	CDD:290606	14/93 (15%)
		I-set	382..462	CDD:254352	24/100 (24%)
		IGc2	396..446	CDD:197706	15/58 (26%)
		Ig	466..561	CDD:299845	17/108 (16%)
		IG_like	478..561	CDD:214653	16/96 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910