DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment side-VIII and MERTK

DIOPT Version :9

Sequence 1:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster
Sequence 2:	NP_006334.2	Gene:	MERTK / 10461	HGNCID:	7027	Length:	999	Species:	Homo sapiens

Alignment Length:	968	Identity:	178/968 - (18%)
Similarity:	305/968 - (31%)	Gaps:	321/968 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 RAENNNLTTPIISSVVLDMNLRPLIVK------LQGE------NRALSAGNSYQLSCVVIGARPA 308
            |....|:..|.::||. ...|.||..|      :..|      |.::|..|.||          .
Human    72 RPHTGNVAIPQVTSVE-SKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQ----------D 125

  Fly   309 PTITWWKGSTPMKNTHEIAT---PDGNLTTSVLTFTPTI---DDRGKFLSCRAEQSMIPESGMED 367
            .||:|||....:...|...|   ||..:|..:.:|:.|.   .|.|.:: |:  ..:..|..:.|
Human   126 TTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYI-CK--MKINNEEIVSD 187

  Fly   368 GWKLDIYHIPVVSLELGTNSLNSTLREGIDVFFECNIKSNPWIYEVSWRHNGKILTNNPAEGIAV 432
            ...:::..:|..:.:  ..|:|.|.....::  .|.....|....:.|..|...:...|.:..:
Human   188 PIYIEVQGLPHFTKQ--PESMNVTRNTAFNL--TCQAVGPPEPVNIFWVQNSSRVNEQPEKSPS- 247

  Fly   433 SNQSLVLQNASRARSGIYTCVGSNREGDGESNPVQLDIRFAPVCRPRQRLSYSSGRHETVKVA-- 495
                 ||.........:::|...|.:|...|..||::|:..|  .|...:|..:....::.::
Human   248 -----VLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIP--SPPTEVSIRNSTAHSILISWV 305

  Fly   496 -----------CEI---DANPAEATYVWKFNATQGETVDIPASQVAVDRGRSIAHYTPMTENDYG 546
                       |.|   :|:|.....|..||     |..:| ....:.:.:::|:|
Human   306 PGFDGYSPFRNCSIQVKEADPLSNGSVMIFN-----TSALP-HLYQIKQLQALANY--------- 355

  Fly   547 TLLCWATNEIG-DQSEPCVYTIFPAGEPDPL-LNCTV-LNQTSTGFQIECIE-----------GF 597
            ::.....|||| ....|.:......|.|... ||.|| ||::|....|..::           |:
Human   356 SIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGY 420

  Fly   598 -------NGGLQQDFIMEVYMNGTTRHPKISKSKRPYFEVSGLVPGMGYNVFLIANNSKGRSNAT 655
                   :.|:.::.:.||..||       |:::     :|..|......|.:.|....|
Human   421 RISHVWQSAGISKELLEEVGQNG-------SRAR-----ISVQVHNATCTVRIAAVTRGG----- 468

  Fly   656 ILQVYTLKDPEKQTVKITFTKSFQGLRPA-----YTKTKATATTTSD-------CVCDEDEFLNL 708
               |....||    |||..        ||     |..:...|...:|       |.|.   |:.:
Human   469 ---VGPFSDP----VKIFI--------PAHGWVDYAPSSTPAPGNADPVLIIFGCFCG---FILI 515

  Fly   709 G----------KGISHDEGTDADQQEDLSLAYAPV---------IEDIRPFLGILAGIVGSIFLV 754
            |          |.:...:..:|..:||..|....:         ||.....||:...:...:..|
Human   516 GLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDV 580

  Fly   755 ALIIVIVVRVRGSSGRDRNNYSHPGSGVGGVGGVGGTTGNGSGMGGGGGGVGGTTANGNGSLGLL 819
            .:              |||...           :|...|.|.         .|:...||     |
Human   581 VI--------------DRNLLI-----------LGKILGEGE---------FGSVMEGN-----L 606

  Fly   820 ASNNNGSLVIGT----LGHNGGQSVQDMHRIGRETCHVTSSLDSIDKNPDIIPQDGHDLDDEWTT 880
            ...:..||.:..    |.::..:.:::.  :....|....|      :|::|
Human   607 KQEDGTSLKVAVKTMKLDNSSQREIEEF--LSEAACMKDFS------HPNVI------------- 650

  Fly   881 KGHGRTYATAAMAEQNAVITSGTYDHLMPTYAVVDKKTAPPPGHGQYIQYNTLIPVSKMGAYANQ 945
                                     .|:.....:..:..|.|        ..::|..|.|
Human   651 -------------------------RLLGVCIEMSSQGIPKP--------MVILPFMKYG----- 677

  Fly   946 QQQLQQQPQQKTELSYSELSAPLVSGP--VGVQRMAPYCSATLGRPGRQAELKRAEPNIYSQVNV 1008
                    ...|.|.||.|.    :||  :.:|.:..:                       .|::
Human   678 --------DLHTYLLYSRLE----TGPKHIPLQTLLKF-----------------------MVDI 707

  Fly  1009 MMDDEILA-------DLQAATASGRSYVAGAVVDNVGGAPNLYVQGYATRIDLAHHPMPMYSTSP 1066
            .:..|.|:       ||.|.....|..:...|.| .|.:..:|...|..:..:|..|:...:...
Human   708 ALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVAD-FGLSKKIYSGDYYRQGRIAKMPVKWIAIES 771

  Fly  1067 M----FGTNSTI--TGVTMSHPSQLATFSPTPPPPIFTHSM---VTTGDGLLQPVTCM 1115
            :    :.:.|.:  .||||   .::||...||.|.:..|.|   :..|..|.||..|:
Human   772 LADRVYTSKSDVWAFGVTM---WEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCL 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845
		IG_like	60..166	CDD:214653
		Ig	182..266	CDD:299845	2/9 (22%)
		Ig	296..373	CDD:299845	19/82 (23%)
		IG_like	389..464	CDD:214653	12/74 (16%)
		IGc2	394..459	CDD:197706	9/64 (14%)
		Ig_3	490..554	CDD:290638	11/79 (14%)
MERTK	NP_006334.2	IG	111..193	CDD:214652	22/94 (23%)
		Ig	111..176	CDD:143165	19/75 (25%)
		Ig2_Tyro3_like	199..279	CDD:143226	16/89 (18%)
		IG_like	203..280	CDD:214653	16/84 (19%)
		FN3	284..378	CDD:238020	19/110 (17%)
		FN3	386..478	CDD:238020	24/115 (21%)
		PTKc_Mer	579..862	CDD:271106	63/385 (16%)
		Pkinase_Tyr	587..854	CDD:285015	59/363 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000