DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11192 and PRSS1

DIOPT Version :9

Sequence 1:	NP_611479.2	Gene:	CG11192 / 37309	FlyBaseID:	FBgn0034507	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	XP_011514713.1	Gene:	PRSS1 / 5644	HGNCID:	9475	Length:	472	Species:	Homo sapiens

Alignment Length:	263	Identity:	87/263 - (33%)
Similarity:	128/263 - (48%)	Gaps:	30/263 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LMALVAYAGATPTPGDGRIVGGEVATIQEFPYQVSVQLQGRHICGGAIIGIDTVLTAAHCFEDPW 74
            ::..||.|.|.|...|.:||||........|||||:. .|.|.|||::|....|::|.||::
Human   231 ILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLN-SGYHFCGGSLINEQWVVSAGHCYK--- 291

  Fly    75 SSADYTVRVGSSEH-----ESGGHVLSLRRVIAHGDYNPQSHDNDLALLILNGQLNFTEHLQPVP 134
              :...||:|  ||     |.....::..::|.|..|:.::.:||:.|:.|:.:......:..:.
Human   292 --SRIQVRLG--EHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTIS 352

  Fly   135 LAALADPPTADTRLQVSGWGFQAEESAVSGEVGVSPQLRFVDVDLVESNQCRRAYSQVLPITRRM 199
            |...  ||...|:..:||||..|...|     ....:|:.:|..::...:|..:|..  .||..|
Human   353 LPTA--PPATGTKCLISGWGNTASSGA-----DYPDELQCLDAPVLSQAKCEASYPG--KITSNM 408

  Fly   200 ICAA--RPGRDSCQGDSGGPLVGYAAEEGPARLYGIVSWGLGCANPNFPGVYTNVAAFRSWIDEQ 262
            .|..  ..|:||||||||||:|      ...:|.|:||||.|||..|.|||||.|..:..||...
Human   409 FCVGFLEGGKDSCQGDSGGPVV------CNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNT 467

  Fly   263 LDA 265
            :.|
Human   468 IAA 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11192	NP_611479.2	Tryp_SPc	27..259	CDD:214473	78/238 (33%)
CG11192	NP_611479.2	Tryp_SPc	28..262	CDD:238113	80/240 (33%)
PRSS1	XP_011514713.1	Ig	19..119	CDD:299845
		IG_like	29..113	CDD:214653
		Tryp_SPc	248..464	CDD:214473	78/238 (33%)
		Tryp_SPc	249..467	CDD:238113	80/240 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBP0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D469244at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820