DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11192 and PRSS36

DIOPT Version :9

Sequence 1:	NP_611479.2	Gene:	CG11192 / 37309	FlyBaseID:	FBgn0034507	Length:	279	Species:	Drosophila melanogaster
Sequence 2:	NP_775773.2	Gene:	PRSS36 / 146547	HGNCID:	26906	Length:	855	Species:	Homo sapiens

Alignment Length:	261	Identity:	93/261 - (35%)
Similarity:	132/261 - (50%)	Gaps:	29/261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PTPGDGRIVGGEVATIQEFPYQVSVQLQGRHICGGAIIGIDTVLTAAHCFE-----DPWSSADYT 80
            |.| ..|||||..|....:|:|||:...|.|||||::|....||:|||||.     :|  :|:::
Human    41 PEP-SARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLEP--AAEWS 102

  Fly    81 VRVGSSEHE---SGGHVLSLRRVIAHGDYNPQSHDNDLALLILNGQLNFTEHLQPVPLAALADPP 142
            |.:|....:   .|.|..::..::...:|:......|||||.|....:....:.||.|...:...
Human   103 VLLGVHSQDGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRF 167

  Fly   143 TADTRLQVSGWGFQAEESAVSGEVGVSPQLRFVDVDLVESNQCRRAYSQ------VLPITRRMIC 201
            ...|....:|||...|    :..:.:...|:.|::.|:....|:..|||      .|.|...|:|
Human   168 VHGTACWATGWGDVQE----ADPLPLPWVLQEVELRLLGEATCQCLYSQPGPFNLTLQILPGMLC 228

  Fly   202 AARP--GRDSCQGDSGGPLVGYAAEEGPARLY--GIVSWGLGCANPNFPGVYTNVAAFRSWIDEQ 262
            |..|  .||:||||||||||   .||| .|.:  ||.|:|.||...|.|||:|.||.:.:||.||
Human   229 AGYPEGRRDTCQGDSGGPLV---CEEG-GRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQ 289

  Fly   263 L 263
            :
Human   290 V 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11192	NP_611479.2	Tryp_SPc	27..259	CDD:214473	87/249 (35%)
CG11192	NP_611479.2	Tryp_SPc	28..262	CDD:238113	88/251 (35%)
PRSS36	NP_775773.2	Tryp_SPc	46..286	CDD:214473	87/249 (35%)
		Tryp_SPc	47..289	CDD:238113	88/251 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..316
		Tryp_SPc	330..538	CDD:304450
		Tryp_SPc	601..783	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940