DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED8 and Med8

DIOPT Version :9

Sequence 1:	NP_722456.1	Gene:	MED8 / 37305	FlyBaseID:	FBgn0034503	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	XP_006503554.1	Gene:	Med8 / 80509	MGIID:	1915269	Length:	284	Species:	Mus musculus

Alignment Length:	291	Identity:	120/291 - (41%)
Similarity:	167/291 - (57%)	Gaps:	46/291 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQRDEKLFELTLDTVLQRLNDLKLAVLSMIQKLELEYETI----------------NWPTFLDNF 49
            |||:||..|.:||.:|.::.|||.::.|.|.|||.||:.:                :.|:.||:|
Mouse     1 MQREEKQLEASLDALLNQVADLKNSLGSFIYKLENEYDRLTCKSGSCLCQTQGCESSGPSVLDSF 65

  Fly    50 AIISSHLTGLTKILAKEQCPPLRNRTVLPLLVSMDRDDTLINITEGRVPVFSHDIVPDYLRTRPD 114
            |::|..|..|.|:|..|:.|..||:.::||::|.|||:.|:..||||||||||::|||:|||:||
Mouse    66 ALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPD 130

  Fly   115 PITEQKMLQNEQKAANLTNDAAMKQVTQYNKVVSHVLDMVSKAREEWEIESSSRTGIQQTSSMAD 179
            |..|::..|....||.:..|||.||:...||:.|::|:.:||  ||.|.||......:||.:..|
Mouse   131 PEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISK--EERESESGGLRPNKQTFNPGD 193

  Fly   180 TQLLVAAVGMGKGLKLTNYGP----GPGMMVPPSIRAPSPMGGPA-----MSPG--NVQQ----- 228
            |..|||||..|||  |:|:.|    |||....|.  |.:.:.|.:     ..||  |.||
Mouse   194 TNALVAAVAFGKG--LSNWRPSGSSGPGQPGQPG--AGTILAGASGLPQVQMPGAPNQQQPMLSG 254

  Fly   229 -------QLGKAPSAVKTNIKSANQVHPFSR 252
                   |.||.||.:|||||||: :||:.|
Mouse   255 VQMAQAGQPGKMPSGIKTNIKSAS-MHPYQR 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED8	NP_722456.1	Med8	1..249	CDD:287234	117/286 (41%)
Med8	XP_006503554.1	Med8	1..281	CDD:370903	117/286 (41%)
Med8	XP_006503554.1	Med15	<212..>269	CDD:312941	16/58 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834661
Domainoid	1	1.000	193	1.000	Domainoid score	I3196
eggNOG	1	0.900	-	-		E1_KOG3583
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10560
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3810
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48625
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008222
OrthoInspector	1	1.000	-	-		oto94318
orthoMCL	1	0.900	-	-		OOG6_107763
Panther	1	1.100	-	-	LDO	PTHR13074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2639
SonicParanoid	1	1.000	-	-		X7257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790