DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED8 and MED8

DIOPT Version :9

Sequence 1:	NP_722456.1	Gene:	MED8 / 37305	FlyBaseID:	FBgn0034503	Length:	252	Species:	Drosophila melanogaster
Sequence 2:	NP_443109.2	Gene:	MED8 / 112950	HGNCID:	19971	Length:	301	Species:	Homo sapiens

Alignment Length:	274	Identity:	120/274 - (43%)
Similarity:	164/274 - (59%)	Gaps:	28/274 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQRDEKLFELTLDTVLQRLNDLKLAVLSMIQKLELEYETINWPTFLDNFAIISSHLTGLTKILAK 65
            |||:||..|.:||.:|.::.|||.::.|.|.|||.||..:.||:.||:||::|..|..|.|:|..
Human     1 MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKH 65

  Fly    66 EQCPPLRNRTVLPLLVSMDRDDTLINITEGRVPVFSHDIVPDYLRTRPDPITEQKMLQNEQKAAN 130
            |:.|..||:.::||::|.|||:.|:..||||||||||::|||:|||:|||..|::..|....||.
Human    66 EKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAAR 130

  Fly   131 LTNDAAMKQVTQYNKVVSHVLDMVSKAREEWEIESSSRTGIQQTSSMADTQLLVAAVGMGKGLKL 195
            :..|||.||:...||:.|::|:.:||  ||.|.||......:||.:..||..|||||..|||  |
Human   131 IGADAAQKQIQSLNKMCSNLLEKISK--EERESESGGLRPNKQTFNPTDTNALVAAVAFGKG--L 191

  Fly   196 TNYGP----GPGMMVPPS----------------IRAPSPMGGPAMSPGNVQQ--QLGKAPSAVK 238
            :|:.|    |||....|.                ..|||.. .|.:|...:.|  |.||.||.:|
Human   192 SNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQ-QPMLSGVQMAQAGQPGKMPSGIK 255

  Fly   239 TNIKSANQVHPFSR 252
            ||||||: :||:.|
Human   256 TNIKSAS-MHPYQR 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED8	NP_722456.1	Med8	1..249	CDD:287234	117/269 (43%)
MED8	NP_443109.2	Med8	1..265	CDD:287234	120/274 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144538
Domainoid	1	1.000	190	1.000	Domainoid score	I3285
eggNOG	1	0.900	-	-		E1_KOG3583
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10560
Inparanoid	1	1.050	192	1.000	Inparanoid score	I3864
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48625
OrthoDB	1	1.010	-	-		D1392867at2759
OrthoFinder	1	1.000	-	-		FOG0008222
OrthoInspector	1	1.000	-	-		oto90733
orthoMCL	1	0.900	-	-		OOG6_107763
Panther	1	1.100	-	-	LDO	PTHR13074
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2639
SonicParanoid	1	1.000	-	-		X7257
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800