DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and Tdrd7

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_006238169.1	Gene:	Tdrd7 / 85425	RGDID:	619724	Length:	1146	Species:	Rattus norvegicus

Alignment Length:	1339	Identity:	256/1339 - (19%)
Similarity:	477/1339 - (35%)	Gaps:	375/1339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EYVAKVVRALITSAKPPVTLRSIVADYMEIEGEPIPFRRLGYSNDQELLKDSN---QFNFHQSGN 69
            :.|:|::||::.|.|..:.|..:..:|..:.|:.|||::|||...:..|:...   :....:||
  Rat    38 DLVSKMLRAVLQSHKNGIVLPRLQGEYRSLTGDWIPFKQLGYPTLEAYLRSVPAVVRIEASRSG- 101

  Fly    70 QVFITAKYNANTEHIVRMVRQQKTSKSTS---------LSKPTPIAQKPKPIAQKHTHGNKYHYQ 125
            ::...|.....|..|.::|.:|:|||..:         :.|..|...:.||.|.....|....|
  Rat   102 EIVCYAVACTETARIAQLVARQRTSKRKTGRQINCQMRVKKTMPFFLEGKPKATLRQPGFASDY- 165

  Fly   126 QRNKQPN----HQPDQEIGRAAKCE-----NQAIAEHKQDLTGIITQELFESFNNIQG-PFSENL 180
            ..:|:||    .:....:|..|..:     :..:..|       ::.....|...::. |.:..|
  Rat   166 SISKKPNPTLLREKGSTLGAKADVDMPPYPDAPVQRH-------VSMSANSSVTVLRSHPEASKL 223

  Fly   181 QVFNKNPE----YITRRKKELKKEDDLDRGQITKEVAREKQKEKETRDRAVTETIFVTIE----- 236
            |....:|:    .:...|..|.       ......::|...||       |.:.:..|:|
  Rat   224 QFMGYSPKPHCLLLFSPKSSLP-------APFQTHISRACPKE-------VNDNLNQTVEKPNVT 274

  Fly   237 ------NKKAPVMNGHGPRHVKVANGQDKHNDG----------KPPLRAILGNSASQRQQDTSTV 285
                  ||...|.|       ::....||||:|          |...:..|.....|:.:
  Rat   275 PPASYTNKMDEVQN-------RIKEILDKHNNGIWISKLPHFYKEFYKEDLNQGVLQQFE----- 327

  Fly   286 YHSPE-SSFKRP---RHPRVMYPGHQRTTGVSVNHRLKVTPQSDAPTPAVAPITPPASPEYAQTT 346
             |.|. .:.::|   ....::||..:...     .|....|:.:.|.|      |||
  Rat   328 -HWPHICTVEKPCGGGQDLLLYPAKREQP-----LRSDQDPEKERPPP------PPA-------- 372

  Fly   347 TAAKATYKEDIHGGQGETGNVVTNPKVKVPLKFDPSLDPVSTLNFYCAANDFEKPAYNIFNKLRN 411
                                    |:.:||.|..|::.|           |.::....:..|..
  Rat   373 ------------------------PRQEVPSKGSPAVMP-----------DVKEKVAELLGKYS- 401

  Fly   412 LHCSVQIAGDVYSSYPQEFTD------KETAYQRTAQIAIQRIMHAQSHQKLSACTFSDVEFIDG 470
                   :|...|:.|:.|.|      .|.|.:..|.::             ..||   :.:|.|
  Rat   402 -------SGLWASALPKAFEDMYKVKFPEDALKNLASLS-------------DVCT---INYISG 443

  Fly   471 LYKELLKHPHGILGHKLEDWYGSTFRQHLPSHWYDLIVK-----SNKIRVEHGIDPRIILFANDP 530
            ..::      .||..||.          ||:   |.|:|     .....::..|:...:....:.
  Rat   444 NTQK------AILYAKLP----------LPT---DKILKDEAQAQGDFDIKSMIEQEYLQIEKNM 489

  Fly   531 GSSEPDRTSITTLPQMVLPWQSSEGGSHDWNMFISFCDSTKIVWARMIDQIANFEELT-KHIGR- 593
            ..|..|.....|:|.:|:|.::|.                    :.::.:::|..::. :::|:
  Rat   490 AESADDFVEDITVPPLVIPTEASP--------------------SVLVVELSNTNDVVIRYVGKD 534

  Fly   594 ----------QMESPHFRQKVSKPYAQEVYLVEM------PDGWNRVRAISVDEETRSGRYHFID 642
                      :|:..:.|.....| .|.|::.::      .|.|.|.:.||.||  ...:..::|
  Rat   535 YSAAQELMEDEMKEYYSRNPRVTP-IQTVHVGQLLAVNAEEDAWLRAQIISTDE--NKIKVCYVD 596

  Fly   643 FGDVAMFHSEDLFHCPPQFLALPAQAVCLSMYALDKFEDHPHALQVLTKELDGQTVVAHVLTTEK 707
            :|..........:...|:|.:|..||....:..|:...|.|:.::|:.....|:.....:|  :|
  Rat   597 YGFCENIEKSKAYRLNPRFCSLSFQATKCKLAGLEILNDDPNLVKVVESLTCGKIFAVEIL--DK 659

  Fly   708 QFLELGGSAQGVVENGKRRACLVATLYDTSTAEDIHLNDLVAKRITKCTPAPSLSDEKKI-GKTT 771
            ..:.|                  ..|||||..:||::|....|.|  |.  .||....:: ...|
  Rat   660 SDIPL------------------VVLYDTSGEDDININATCLKAI--CD--RSLEVHLQVDAMYT 702

  Fly   772 PILVSHINDDGDLMVLLRNDDLKFVERSIAQTVADLGEQDRVSYSDLLHDRH------------- 823
            .:.|::|..||.|...:....|..:...:.:|            .|..|.:|
  Rat   703 NVKVTNICSDGTLYCQVPCKGLNKLNDLLHKT------------EDYFHCKHMTSEYFISLPFCG 755

  Fly   824 ---IFVCDETVDGVKQWFRGRLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRLEAN-NRALAT 884
               :|.|.      .:|.|..:..   .....:.||.::|.|......:|.:..:... .:.:..
  Rat   756 KICLFHCK------GKWLRVEITN---VHSSRALDVQFLDSGNSTSVKVSELREIPPRFLQEMLA 811

  Fly   885 FPPQAIPVRLHDVPEIGGHMLHRLRGLIPWRTEALL--------------KVVAMDGGKPLVNVF 935
            .|||||...|.|:|:..|          .|..:|:|              ||..:|..:.:..|:
  Rat   812 IPPQAIKCCLADLPQSIG----------MWTPDAVLWLRDSVLNCSDCSIKVTKVDEARGVAYVY 866

  Fly   936 IREDPESMYMCVNIGLRLELEMASSIHPEKYDHTLLSSNVQLPRRGSF--------SSVFSNQSS 992
            :                        ..|:.:.....|.|.|:.....:        |:|.:..||
  Rat   867 L------------------------FTPKNFPDPHRSINRQITNADLWKHQKDVFLSAVSAAASS 907

  Fly   993 SSDLVATTP-PVTPEK----------KPSARSTGSTFSSLMLKDYEAIPAVGAYFEVRVALSVNP 1046
            ..:..|:|| |.:|.:          :.|.....|:||...|.....:...|.:.:|.|.::.:|
  Rat   908 PGNRNASTPAPGSPAESLRKSHPEVLRKSVLDHTSSFSLEELPPPVHLSKSGEHMDVYVPVACHP 972

  Fly  1047 GHFAVQPYKYYNQLQTLMKNLQEHCQKTAAKGVQPSQLAIGEAYAAPDSEGVYHRVSIHKIY-DE 1110
            |||.:||::..::|:.||:.:..:...:..:.:...:   .:.||| ..|..::||.:..|. :.
  Rat   973 GHFVIQPWQEIHKLEVLMEEMILYYSVSEERHIAVER---DQVYAA-KVENKWYRVLLKGILTNG 1033

  Fly  1111 IIHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRELSLGQK 1175
            ::.|..:|.|...::...:::.|....||||..|:.|||.|::.:.  ||:|..:.||.....:.
  Rat  1034 LVSVYELDYGKHELVNIRKVQPLVDVFRKLPFQAVTAQLAGVKCSQ--WSEEASMVFRNHVEKKP 1096

  Fly  1176 FIGIVRRMTKQKD-GGRALCLELVDTSTP-KDIKLHEIL 1212
            .:.:|:.:.:..: ..|.:.:.|||||.| .|..:|:.:
  Rat  1097 LVALVQTVIEHANPWDRKVVVYLVDTSLPDTDTWIHDFM 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586	22/86 (26%)
		TUDOR	563..673	CDD:278965	21/127 (17%)
		TUDOR	766..896	CDD:278965	26/147 (18%)
		TUDOR	1032..1151	CDD:278965	31/119 (26%)
		TUDOR	1087..1131	CDD:119391	10/44 (23%)
Tdrd7	XP_006238169.1	LOTUS_1_TDRD7	38..124	CDD:193600	22/86 (26%)
		LOTUS_2_TDRD7	283..349	CDD:193587	13/78 (17%)
		LOTUS_3_TDRD7	388..452	CDD:193588	16/93 (17%)
		TUDOR	507..629	CDD:278965	23/144 (16%)
		TUDOR	565..607	CDD:119391	9/43 (21%)
		TUDOR	696..823	CDD:278965	26/147 (18%)
		TUDOR	755..800	CDD:119391	9/53 (17%)
		TUDOR	957..1074	CDD:278965	31/120 (26%)
		TUDOR	1011..1055	CDD:119391	10/44 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4560
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276848at2759
OrthoFinder	1	1.000	-	-		FOG0005497
OrthoInspector	1	1.000	-	-		oto97337
orthoMCL	1	0.900	-	-		OOG6_106750
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970