Protein Alignment tapas and TDRD1

DIOPT Version :10

• Sequence 1: NP_611475.3
• Gene: tapas / 37304
• FlyBaseID: FBgn0027529
• Length: 1222
• Species: Drosophila melanogaster
• Sequence 2: NP_942090.1
• Gene: TDRD1 / 56165
• HGNCID: 11712
• Length: 1189
• Species: Homo sapiens
• Alignment Length: 1065
• Identity: 219/1065 - (20%)
• Similarity: 366/1065 - (34%)
• Gaps: 276/1065 - (25%)

  Fly   264 KPPLRAILGNSASQRQQDTSTVYHSPESSFKRPRHPRVMYPGHQRTTGVSVNHRLKVTPQSDAPT 328
            |.|...:..|:........:..::..::..|.|.|..:..||   |.....|.|||.:...:...
Human     4 KSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPG---TLPNHPNFRLKSSENGNKKN 65

  Fly   329 PAVAPITPPASPEYAQTTTAAKATYKE------------DIHGGQGE-----TGNVVTNPKVKVP 376
            ..:          ..:.|....|:.::            ::.|.:|:     .||.|:.|..:
Human    66 NFL----------LCEQTKQYLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAE-- 118

  Fly   377 LKFDPSLDPVSTLNFYCAANDFEKPAYNI-------FNKLRNLHCSVQIAGDVYSSYPQEFTD-- 432
                 |..|...:|.        ||..|:       .|||        :...:..|.|..||.
Human   119 -----SNSPPKEVNI--------KPGNNVRPAKSKKLNKL--------VENSLSISNPGLFTSLG 162

  Fly   433 ---KETAYQRTAQIAIQRIMHA-QSHQKLSACTFSDVEFIDGLYKELLKHPHGIL-------GHK 486
               :.|...|.......|.... |::...:||...|..            .|.|:       .||
Human   163 PPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWS------------AHSIVCRPVQPNFHK 215

  Fly   487 LEDWYGSTFRQHLPSHWYDLIVKSNKIRVEHGIDPRIILFANDPGSSEPDRTSITTLPQMVLPWQ 551
            ||:......:.         :..:||.....|:...|.::|        :|...:.|..:.|...
Human   216 LENKSSIETKD---------VEVNNKSDCPLGVTKEIAIWA--------ERIMFSDLRSLQLKKT 263

  Fly   552 SSEGGS-----HDWNMFISFCDSTKIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPYAQE 611
            ....|:     |..:.::....|..:.:...:.  |:.:|...::         .:|...|...|
Human   264 MEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLS--ASLKETYANV---------HEKDYIPVKGE 317

  Fly   612 V----YLVEMPDGWNRVRAISVDEETRSGRYHFIDFGDVAMFHSEDLFHC-------PP----QF 661
            |    |.|:..  |||....:||.:.:.....:||:|:..:.....::|.       ||    .|
Human   318 VCIAKYTVDQT--WNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCF 380

  Fly   662 LA--LPAQ----AVCL------------SMYALDKFEDHPHALQVLTKELDGQTVVAHVLTTEKQ 708
            :|  :||:    :.|:            |:..:|..|:......|..:..:...::.|||
Human   381 VANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEVVTFAVEVELPNSGKLLDHVL----- 440

  Fly   709 FLELGGSAQGVVENGKRRACLVATLYDTSTAED-----------IHLNDLVAKRITKCTPAPSLS 762
             :|:|...:...::.|:...      |.|..||           :..:||:.|.:|
Human   441 -IEMGYGLKPSGQDSKKENA------DQSDPEDVGKMTTENNIVVDKSDLIPKVLT--------- 489

  Fly   763 DEKKIGKTTPILVSHINDDGDLMVLLRNDDLKFVE-----RSIAQTVADLGEQDRVSYSDLLHDR 822
              ..:|.....:|:||....|.          |.:     |.:|:..|.|.:     |.|.|..|
Human   490 --LNVGDEFCGVVAHIQTPEDF----------FCQQLQSGRKLAELQASLSK-----YCDQLPPR 537

  Fly   823 HIF------VCDETVDGVKQWFRGRLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRLEANNRA 881
            ..|      :|........||:|..::.   ...|||..|.|||.|   ...|.::.||......
Human   538 SDFYPAIGDICCAQFSEDDQWYRASVLA---YASEESVLVGYVDYG---NFEILSLMRLCPIIPK 596

  Fly   882 LATFPPQAIPVRLHDV-PEIGGHMLHRLRGLIPWRTEALLKVVAMDGGKPLVNVFIREDPESMYM 945
            |...|.|||...|..| |.:|           .|..||:..:..:...| ::.|.:.:..|:..:
Human   597 LLELPMQAIKCVLAGVKPSLG-----------IWTPEAICLMKKLVQNK-IITVKVVDKLENSSL 649

  Fly   946 CVNIGLRLELEMASSIHPEKYDHTLLSSNVQLPRRGSFSSVFSNQSSSSDLVATTPPVTPEKKPS 1010
                   :||...|..........||.:...:   |..|.|   ....||:..|:.|:..|.|.:
Human   650 -------VELIDKSETPHVSVSKVLLDAGFAV---GEQSMV---TDKPSDVKETSVPLGVEGKVN 701

  Fly  1011 ARSTGSTFSSLMLKDYEAIPAVGAYFEVRVALSVNPGHFAVQPYK--YYNQLQTLMKNLQEHCQK 1073
            ....  |:..|         .|....:|.|.:..:||.|.....|  ...:|..|.|:|.||||:
Human   702 PLEW--TWVEL---------GVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQ 755

  Fly  1074 TAAKGVQPSQLAIGE---AYAAPDSEGVYHRVSIHKIY-DEIIHVRFVDVGDDGVIACDQLKTLN 1134
            ....|.:..   ||:   |:.|.|  |.::|..:.:|. :..:.|.|||.|:...:..|:|:.::
Human   756 KLPNGFKAE---IGQPCCAFFAGD--GSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMIS 815

  Fly  1135 PELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRELSLGQKFIGIVRRMTKQKDGGRALCLELVD 1199
            .....||...:..||..||..:..||:|...||:....|.|....|..:|:...|     :||.|
Human   816 STFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIG-----VELTD 875

  Fly  1200 TSTPKDIKLHEILINE----KHAQP 1220
            .||.....:.::||:|    |.|.|
Human   876 LSTCYPRIISDVLIDEHLVLKSASP 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586
		TUDOR	563..673	CDD:425754	25/142 (18%)
		TUDOR	769..896	CDD:425754	35/137 (26%)
		TUDOR	1034..1151	CDD:425754	34/122 (28%)
TDRD1	NP_942090.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..66		13/64 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	79..138		12/73 (16%)
		zf-MYND	170..206	CDD:460312	8/47 (17%)
		Tudor_TDRD1_rpt1	268..396	CDD:410479	26/140 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	450..469		5/24 (21%)
		Tudor_TDRD1_rpt2	517..598	CDD:410480	24/91 (26%)
		TUDOR	715..832	CDD:425754	34/121 (28%)
		Tudor_TDRD1_rpt4	944..1059	CDD:410482