DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and RNF17

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_011533454.1	Gene:	RNF17 / 56163	HGNCID:	10060	Length:	1699	Species:	Homo sapiens

Alignment Length:	1357	Identity:	253/1357 - (18%)
Similarity:	462/1357 - (34%)	Gaps:	429/1357 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EKQEVLEYVAKVVRALITSAKPPVTLRSIVADYMEIEGEPIPFRRLGYSNDQELLKDSN------ 60
            ||:..|.....:.|||..|.    :||: ..|..:|      .|.|..::|.||.:.|:
Human   259 EKKNNLNAAMNIARALQLSP----SLRT-YCDLNQI------IRTLQLTSDSELAQVSSPQLRNP 312

  Fly    61 ---QFN-------FHQSGNQVFITAKYNANTEHIVRMVRQQKTSKSTSLS---KPTPIAQK---- 108
               ..|       |:..|...|..:......|:.:|...|:|.:....||   ...|:.:|
Human   313 PRLSVNCSEIICMFNNMGKIEFRDSTKCYPQENEIRQNVQKKYNNKKELSCYDTYPPLEKKKVDM 377

  Fly   109 -------PKPIAQKHTHGNKYHYQQRNKQPNHQPDQEIGRAAKCENQAIAEHKQDLTGIITQELF 166
                   |.|..|..|  |..|.:.:    |.||.:::..|:. :..|:.........:|.:|:.
Human   378 SVLTSEAPPPPLQPET--NDVHLEAK----NFQPQKDVATASP-KTIAVLPQMGSSPDVIIEEII 435

  Fly   167 ESFNNIQG-------------------PFSE--NLQVFNKNPEYITRRKKELKKEDDLD------ 204
            |  :|::.                   .:|:  :.:|..|.......|...|...|.|:
Human   436 E--DNVESSAELVFVSHVIDPCHFYIRKYSQIKDAKVLEKKVNEFCNRSSHLDPSDILELGARIF 498

  Fly   205 ----------RGQITKEVAREKQKEKE----TR----DRAVTETIFVTIENKKAPVMNGHGPRHV 251
                      ||.||:.:..|.:..::    ||    :.|:.:...|...|.:..::.|....||
Human   499 VSSIKNGMWCRGTITELIPIEGRNTRKPCSPTRLFVHEVALIQIFMVDFGNSEVLIVTGVVDTHV 563

  Fly   252 KVANGQDKHNDGKPPLRAILGNSASQRQQDTSTVYHSPESSFKRPRHPRVMYPGHQRTTGVSVNH 316
            :                                                   |.|.....:::|.
Human   564 R---------------------------------------------------PEHSAKQHIALND 577

  Fly   317 RLKVTPQSDAPTPA----VAPITPPASPEYAQTTTAAKATYKEDIHGGQGETGNV----VTNPKV 373
            ...|..:|:..|..    :.|:..|.|         .|....::.:.|..|...|    :.|.|.
Human   578 LCLVLRKSEPYTEGLLKDIQPLAQPCS---------LKDIVPQNSNEGWEEEAKVEFLKMVNNKA 633

  Fly   374 KVPLKFDPSLDPVSTLNFYCAANDFEKPAYNIFNKLRNLHCSVQIAGDVYSSYPQEFTDKETAYQ 438
             |.:|.....|.|..:       |.:||..|            :|:.|:    |....| ...:.
Human   634 -VSMKVFREEDGVLIV-------DLQKPPPN------------KISSDM----PVSLRD-ALVFM 673

  Fly   439 RTAQIAIQRIMHAQSHQKLSACTFSDVEFIDGLYKELLKHPH-GILGHKLEDWYGSTFRQHLPSH 502
            ..|:...|.:   :||                ..|....|.| .||..::.|...:....:.|..
Human   674 ELAKFKSQSL---RSH----------------FEKNTTLHYHPPILPKEMTDVSVTVCHINSPGD 719

  Fly   503 WYDLIVKSNKIRVEHGIDPRIILFANDPGSSEPDRTSITTLPQMVLPWQSSEGGSHDWNMFISFC 567
            :|        :::..|:|   |||                |.:.:..:..||.|.   |:.| .|
Human   720 FY--------LQLIEGLD---ILF----------------LLKTIEEFYKSEDGE---NLEI-LC 753

  Fly   568 DSTKIVWARMIDQ--IANFEELTKHIGRQMESPHF------------RQK--VSKP--------- 607
            .        :.||  :|.||:...:..:.:|..|:            :||  :.||
Human   754 P--------VQDQACVAKFEDGIWYRAKVIELNHWESCWKSCIDRTKQQKLIIQKPVNSSLMLTV 810

  Fly   608 -YAQEVYLVEMPDGWNRVRAISVDEETRSGRYHFIDFGDVAMFHSEDLFHCPPQFLALPAQAV-C 670
             .:..:.:|::     :::.:...:|.   ...::|||:.|....:|:.....:||..|.:|: |
Human   811 CLSHAILIVKV-----QIKGLPGHQEV---EVKYVDFGNTAKITIKDVRKIKDEFLNAPEKAIKC 867

  Fly   671 LSMY-------------ALDKFE--------------------------DHPHALQVLTKELDGQ 696
            ...|             |.:|||                          |...|.::.|..::.|
Human   868 KLAYIEPYKRTMQWSKEAKEKFEEKAQDKFMTCSVIKILEDNVLLVELFDSLGAPEMTTTSINDQ 932

  Fly   697 TVVAHVLTTEKQFLELGGSAQGVVENGKRRACLVATLYDTSTAE----DIH-LNDLVAKRITKCT 756
            .|...:.:.|..:: |..::|..:|           ::|.|..|    ::| ||.:.||.:
Human   933 LVKEGLASYEIGYI-LKDNSQKHIE-----------VWDPSPEEIISNEVHNLNPVSAKSL---- 981

  Fly   757 PAPSLSDEKKIGKTTPILVSHINDDGDLMV--LLRNDDLKFVERSIAQTVADLGEQDRVSYSDLL 819
              |:.:.:....|..|:.:.::.....:.|  ||..:.|..:|..:.....: .:.:.|.:.:.:
Human   982 --PNENFQSLYNKELPVHICNVISPEKIYVQWLLTENLLNSLEEKMIAAYEN-SKWEPVKWENDM 1043

  Fly   820 HDRHIFVCDETVDGVKQWFRG---RLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRLEANNRA 881
            |      |...:....||.||   |:||..|      .:|...|.|.:...::..:.:||.|
Human  1044 H------CAVKIQDKNQWRRGQIIRMVTDTL------VEVLLYDVGVELVVNVDCLRKLEEN--- 1093

  Fly   882 LATFPPQAIPVRLHDVPEIGGH----------MLHRLRGLIPWRTEALLKVVAMDGGK--PL-VN 933
            |.|....::...|.|:...||.          :...|.|.:   ...:|:|.:.:...  || |.
Human  1094 LKTMGRLSLECSLVDIRPAGGSDKWTATACDCLSLYLTGAV---ATIILQVDSEENNTTWPLPVK 1155

  Fly   934 VFIRED-----PESMYMCVNIGLRLELEMASSIHPEKYDHTLLSSNVQLPRRGSFSSVFSNQSSS 993
            :|.|::     ..|.|: :..||.|.....:::   ...|:|...::::|.....|.|.:...::
Human  1156 IFCRDEKGERVDVSKYL-IKKGLALRERRINNL---DNSHSLSEKSLEVPLEQEDSVVTNCIKTN 1216

  Fly   994 SDLVATTPPVTPEKKPSARSTGSTFSSLML-----KDYE--AIPAVGAYFEVRVALSVNPGHFAV 1051
            .|....|..:..|:|.      |.|...:|     :.|:  |||.:.. ||..|:...:.|...|
Human  1217 FDPDKKTADIISEQKV------SEFQEKILEPRTTRGYKPPAIPNMNV-FEATVSCVGDDGTIFV 1274

  Fly  1052 QP-------YKYYNQLQTLMKNLQEHCQKTAAKG-VQPSQLAIGEAYAAPDSEGVYHRVSIHKIY 1108
            .|       .|..|::|:.:|.|          | ::|.....|||.|...|:.:::|..:.::.
Human  1275 VPKLSEFELIKMTNEIQSNLKCL----------GLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV 1329

  Fly  1109 DEIIHVRFVDVG-DDGVIACDQLKTLNPEL--RKLPKMALPAQLYGIQLTDVVWSKE 1162
            ...:.|:::|.| .:.:..|.    |.|.|  ..:|:..:|.||:.......||..:
Human  1330 GGAVRVQYLDHGFTEKIPQCH----LYPILLYPDIPQFCIPCQLHNTTPVGNVWQPD 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586	22/100 (22%)
		TUDOR	563..673	CDD:278965	25/136 (18%)
		TUDOR	766..896	CDD:278965	27/134 (20%)
		TUDOR	1032..1151	CDD:278965	30/129 (23%)
		TUDOR	1087..1131	CDD:119391	10/44 (23%)
RNF17	XP_011533454.1	TUDOR	446..>553	CDD:278965	17/106 (16%)
		TUDOR	702..870	CDD:278965	38/214 (18%)
		TUDOR	758..852	CDD:119391	17/101 (17%)
		TUDOR	990..1106	CDD:278965	26/131 (20%)
		TUDOR	1043..1089	CDD:119391	13/57 (23%)
		TUDOR	1253..1371	CDD:278965	32/132 (24%)
		TUDOR	1308..1353	CDD:119391	11/48 (23%)
		TUDOR	1486..1626	CDD:278965
		TUDOR	1560..1607	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810