DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and tdrd1

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_021335784.1	Gene:	tdrd1 / 553522	ZFINID:	ZDB-GENE-070803-1	Length:	1201	Species:	Danio rerio

Alignment Length:	961	Identity:	197/961 - (20%)
Similarity:	346/961 - (36%)	Gaps:	255/961 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 TGNVVTNPKVKVPLKFDPSLDPVSTLNFYCAANDFEKPAYNIFNKLRNLHCSVQIAGDVYSSYPQ 428
            ||....:|:...|..::..|         .|::..:.|..:...|..:.:|     |||.|| ||
Zfish    21 TGPSSLSPRGPAPAIYEERL---------LASDVLDGPKIDTMRKDISQNC-----GDVLSS-PQ 70

  Fly   429 EFTDKETAYQRTAQIAIQRIMHAQSHQKLSACTFSDVEFIDGLYKELLKHPHGILGHKLEDW--Y 491
                  ||.....|:.  ::.:..|||....||            ...|..:..:..:.:||  :
Zfish    71 ------TAVSMMGQVV--KLCNYCSHQGNLRCT------------RCKKTCYCSVACQTQDWIAH 115

  Fly   492 GSTFRQHLPSHWYDLIVKSNKIRVEHGIDPRIILFANDPGSSEPDRTSITTLPQMV----LPWQS 552
            ....:..:|.      |.|.|.:     :.:.:.:||..|.::....|:...|:.:    |..:.
Zfish   116 RHVCKPSIPE------VTSEKPK-----ESKAVPYANGLGGTQAKEISVDAQPKRIYRRDLHKKV 169

  Fly   553 SEGGSHDWNMFISFCDS------------TKIVWARMID-----------QIANFEELTKHIGRQ 594
            ...||....:|.. |.|            ||.:...:||           |.....|..|.|.:|
Zfish   170 VSKGSEIKVLFFR-CSSLVCYPSIDTLPHTKCLQGTVIDLRNPGMFSIHCQCEEMIESLKKITQQ 233

  Fly   595 MESPH---FRQKVSKPYAQEVYLVE--MPDGWNRVRAISVDEETRSGRYHFIDFG---DVAMFH- 650
            ::..:   |.|:. ||...|:..|:  :...|.|....:||...::....:||||   :||:.|
Zfish   234 LQKTYCSSFAQEY-KPEVGELCAVKFSLDQNWYRAEIQAVDVARKTAGVFYIDFGNEENVALDHI 297

  Fly   651 ---SEDLFHCPPQFLALPAQAVCLSMYALDKFEDHPHALQVLTKELDGQTVVAHVLTTEKQFL-- 710
               ||::...||  .||..   |::            .::.||....|:..:|     .:|.:
Zfish   298 RPLSENIDAVPP--FALQC---CIA------------GVKPLTGSWTGECCIA-----VRQLIAG 340

  Fly   711 -ELGGSAQGVVENGKRRA--CLVAT--------LYDTSTA--EDI--------HLNDLVA----- 749
             .|..:...::.:|...|  .||:|        |.|.|.|  ||:        .:|.|:.
Zfish   341 KSLTFTVLDIMNDGDLLAVDSLVSTLGKHVSTFLIDQSYAIKEDVPVKTQTEHSINSLLTASFEN 405

  Fly   750 -KRI-------TKCTPAPSLSDEKKIGKTTPILVSHINDDGDLMV-LLRNDDLKFVERSIAQTVA 805
             ||.       ::..|...|:  :.:|.:...:|:|:....:::. .|.|          |..:.
Zfish   406 FKRFSGGKNENSEARPPEPLT--QGVGDSFTAVVTHLQSPSEILCQKLEN----------ASIIQ 458

  Fly   806 DLGEQDRV-----SYSDLLHDRHIFVCDETVDGVKQWFRGRLVTRPLNPDEESFDVYYVDDGRQR 865
            .|....||     :.||........||........||:|.:::.   ...|:...|.|:|.|...
Zfish   459 QLQMNLRVHCSNTAASDDFRPAPGTVCCSLFSEDNQWYRAKVLA---YSSEDRVCVGYIDFGNSE 520

  Fly   866 KAHISNIYRLEANNRALATFPPQAIPVRLHDVPEIGGHMLHRLRGLIPWRTEALL---------- 920
            :..::.:..:.....||||   ||||..|..:..:..          .|..||:|
Zfish   521 EVELNRLRPISKELLALAT---QAIPCSLAGIKSLTD----------TWSDEAVLMLKHLVCNRF 572

  Fly   921 ---KVVAMDGGKPLVNVFIR-EDPESMY--MCVNIGLRLELEMASSIHPEKYDHTLLSSNVQLPR 979
               :::....|:.||::... .||::..  :.||:|
Zfish   573 IRVEILGKKDGRALVSMIDESSDPQASVTELLVNMG----------------------------- 608

  Fly   980 RGSFSSVFSNQSSSSDL-VATTPPVTPEKKPSARSTGSTFSSLMLKDYEAIPAVGAYFEVRVALS 1043
               |:::.|.::..::. .||:..:.|..:|.......|.:.|        |..|...|:.::..
Zfish   609 ---FAAIESVETKKNEPDPATSTEIPPLSQPVVEKLEWTGAEL--------PFDGQKVELVISTL 662

  Fly  1044 VNPGHFAVQPYKYYNQ--LQTLMKNLQEHCQKTAAKGVQPSQLAIGEAYAAP-DSEGVYHRVSIH 1105
            .:...|....|...::  |..:...|.:||:...|    |....:||...|. ..:..::|..:.
Zfish   663 KSLDEFYCYNYSKTDEHTLTEMSFELMKHCESERA----PFTPIVGEPCCALFTGDARWYRAMVL 723

  Fly  1106 KIYDE-IIHVRFVDVGDDGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRE 1169
            ::..| ...|.|||.|:...:....||.:...|.|||..|:...|.|::..:..|.||..:||:.
Zfish   724 EVCGEGKARVCFVDYGNSCEVDAAHLKAITQSLLKLPFQAIRCWLAGVEPVEGQWKKEAMLRFQA 788

  Fly  1170 LSLGQKFIGIVRRMTKQKDGGRALCLELVDTSTPKDIKLHEILINEKHAQP 1220
            |..||...|.|..:|::..|     :||.....    .:..:||:|..|:|
Zfish   789 LCAGQPLSGKVLSITEKGYG-----MELESAGQ----TVASVLISEHLAKP 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586
		TUDOR	563..673	CDD:278965	36/144 (25%)
		TUDOR	766..896	CDD:278965	30/135 (22%)
		TUDOR	1032..1151	CDD:278965	28/122 (23%)
		TUDOR	1087..1131	CDD:119391	10/45 (22%)
tdrd1	XP_021335784.1	zf-MYND	83..119	CDD:307734	8/47 (17%)
		TUDOR	210..318	CDD:306940	29/125 (23%)
		TUDOR	429..548	CDD:306940	30/134 (22%)
		TUDOR	652..770	CDD:306940	28/121 (23%)
		TUDOR	908..1020	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910