DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and tdrd7a

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	NP_001092813.1	Gene:	tdrd7a / 406379	ZFINID:	ZDB-GENE-040426-2103	Length:	1079	Species:	Danio rerio

Alignment Length:	1321	Identity:	277/1321 - (20%)
Similarity:	483/1321 - (36%)	Gaps:	371/1321 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LEYVAKVVRALITSAKPPVTLRSIVADYMEIEGEPIPFRRLGYSNDQELLKD-SNQFNFHQS-GN 69
            :|.|.|::||::.|:|..|.:..:..||..:.||.||||:.|:...:..|:. .......:| ..
Zfish     4 VELVKKMLRAVLQSSKHGVAMARLQGDYRALTGEMIPFRKFGHDTLESFLRSIPGVVRLERSIAG 68

  Fly    70 QVFITAKYNANTEHIVRMVRQQKTSKSTSLSKPTPIAQKPKPIAQKHTHGNKYHYQQRNKQPNHQ 134
            :|...|.....|.||.::|.:||..|.|..||                   ..::|.|.:
Zfish    69 EVMCFAGVCEETAHIAQLVARQKNVKKTGCSK-------------------LLNFQMRTR----- 109

  Fly   135 PDQEIGRAAKCENQAIAEHKQDLTGIITQELFESFNNIQGPFSENLQVFNKNPEYITRRKKELKK 199
                                       |..||.               .|..|....|:...:..
Zfish   110 ---------------------------TSHLFS---------------HNVKPRLSLRQPSNMTH 132

  Fly   200 EDDLDRGQITKEVAREKQKEKETRDRAVTETIFVT-IENKKAPV--MNGHGPRHVKVANGQDKHN 261
            .   .||.:|...:.:::             ::.| :.:.:||.  ||...|...|.:....|.|
Zfish   133 P---GRGSVTSFYSTQRK-------------LYSTDLPSSRAPAWQMNRKSPVPEKTSVVPSKIN 181

  Fly   262 DG-KPPLRAILGNSASQR------------------QQDTSTVYHSP-----ESSFKRPRH---- 298
            .. |.||:...|..|.|:                  |:.:|.|:.|.     :|.|:...|
Zfish   182 TNIKTPLKKTSGTPAQQKPVNRADVELVQGRIKQLLQKYSSGVWLSKIPQLYKSMFQEELHIIQE 246

  Fly   299 -------PRVMYPGHQRTTGVSVNHRLKVTPQSDAPTPAVAPI--TPPAS----PEYAQTTTAAK 350
                   ..|..||........|...|:..|:: :|.|..:|.  :|..:    |...|.||...
Zfish   247 VEKWTHICTVEKPGSNNIVDRLVYPVLEPVPKA-SPVPVKSPCKQSPNTALLKQPTLTQKTTRTF 310

  Fly   351 ATYKEDIHGGQGETGNVVTNPKVKVPLKFDPSLDPVSTLNFYCAANDFEKPAYNIFNKLRNLHCS 415
            .|...:|         ..:.||.:.||  .|: .|.||:
Zfish   311 RTLAINI---------PQSTPKPQTPL--SPT-SPNSTM-------------------------- 337

  Fly   416 VQIAGDVYSSYPQEFTDKETAYQRTAQIA-IQRIMHAQSHQKLSACTFSDVEFIDGLYKELLKHP 479
                        .:||..||  .:|..:: |.......:||.|:      .|....|.:.|.|:.
Zfish   338 ------------MDFTLSET--PKTQSLSPITPPSTPPAHQPLT------TELKQKLRQLLNKYS 382

  Fly   480 HGILGHKL----EDWYGSTFRQHLPSHWYDLIVKSNKIRVEHGID---PRIILFA------NDPG 531
            .|:..|.|    ::.:|..|.|::..   ||.:.::...||:.:.   .|.||:.      ..|.
Zfish   383 QGLWAHGLPQLFQEAFGCAFPQYVLE---DLSLLADTCMVEYPMPDNRKRAILYTLPCQVQTQPR 444

  Fly   532 SSEPDR----TSITTLPQMVLPWQSSEGGSHDW-NMFISFCDSTKIVWAR------------MID 579
            |..|..    ||...:|.:::|       :.|: ::|:...:||..|..|            |.:
Zfish   445 SRPPPLVLPCTSNPHVPPLIIP-------TADFHSVFVIEINSTNNVVVRFAGEGYSKSLEVMEE 502

  Fly   580 QIANFEELTKHIGRQ--MESPHFRQKVSKPYAQEVYLVEMPDG---WNRVRAISVDEETRSGRYH 639
            ::.||   ..:||..  :.||...|.|:         |...||   ..:|..:|.|:.    :.:
Zfish   503 EMQNF---YNNIGAGLCLLSPKIGQLVA---------VASSDGAMLRAQVHQLSEDKV----KVY 551

  Fly   640 FIDFGDVAMFHSEDLFHCPPQFLALPAQAVCLSMYALDKFEDHPHALQVLTKELDGQTVVAHVLT 704
            |:|.|...:...:.:|....||:.||.||....:..|:.|...|..|:.|.....|::::|.::
Zfish   552 FLDHGFFDLVSRKTVFQLRDQFMTLPFQATTCQLAGLEPFSTDPVVLKTLQSLAVGRSLLAEIV- 615

  Fly   705 TEKQFLELGGSAQGVVENGKRRACLVATLYDTSTAEDIHLNDLVAKRITKCTPAPSLSDEKKIGK 769
                               :|....:..|||||..:|:::..:..|.:..    .|:.:..::..
Zfish   616 -------------------EREDTPLVVLYDTSENDDVNVTAMCLKALQD----KSMENPLQVNS 657

  Fly   770 T-TPILVSHINDDGDLMVLLRNDDLKFVERSIAQTVADLGEQDRVSYS--DLLHDRHIF--VCDE 829
            . |.:.|:::..||.:...|.:..     ::..:.:.|..|...:|..  :||..|...  ||..
Zfish   658 VYTNVCVTNVCSDGSVYCQLPSRG-----QAKLKDIMDKIEAHFISQLTWELLVSRPFCGKVCLA 717

  Fly   830 TVDGVKQWFRGRLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRL-EANNRALATFPPQAIPVR 893
            ...|  :|.|..::..   ......|:.::|.|......:|.:..: ....:.|.|.|||||...
Zfish   718 KYKG--KWARAEIINL---HGSHVLDILFLDLGLPASLEVSELREIPPIFLKELITIPPQAIKCL 777

  Fly   894 LHDV--------PEIGGHMLHRLRGLIPWRTEALLKVVAMDGGKPL-VNVFIREDPESMYMCVNI 949
            |.|:        ||    .:..||..:..:..:.:|:|.:|..:.: :.:|...:.:.::..||
Zfish   778 LEDLNVDRAVWPPE----AVLWLRETVHNKAPSCMKIVKLDETRTVHIYLFCGNEAQDIHDSVN- 837

  Fly   950 GLRLELEMAS------SIHPEKYDHTLLSSNVQLPRRGSFSSVFSNQSSSSDLVATTPPVTPEKK 1008
                 .::||      .::..|.:.   :|.:.||..|.                   |..|...
Zfish   838 -----RQLASCPFWKQDVYANKINK---ASELFLPDAGE-------------------PSGPSPA 875

  Fly  1009 PSARSTGSTFSSLMLKDYEAIPAVGAYFEVRVALSVNPGHFAVQPYKYYNQLQTLM------KNL 1067
            ||        ::|.|.....:|.||...:|.|:::.:||||.:||::...:|..||      .|.
Zfish   876 PS--------NALTLPPQLNLPLVGQNMDVFVSVACHPGHFVLQPWQDLYKLVVLMGEMVLFYNK 932

  Fly  1068 QEHCQKTAAKGVQPSQLAIGEAYAAPDSEGVYHRVSIHKIY-DEIIHVRFVDVGDDGVIACDQLK 1131
            ||         |.|..:.....||| ..:..:|||.:..:. :.::.|..:|.|...:|...||:
Zfish   933 QE---------VTPVDIQKNNVYAA-KIDNNWHRVLVKGLLTNGLVSVYELDYGKYELINYTQLQ 987

  Fly  1132 TLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRELSLGQKFIGIVRRMTKQKDG----GRA 1192
            .|..|.|:||...:.|||..::  ..||.:|..:.||. .:.:|  .:|.::...::|    .|.
Zfish   988 PLIEEFRQLPFQGISAQLADVK--KEVWCEEASMVFRN-HVEKK--PLVAQIESVEEGEWPWERK 1047

  Fly  1193 LCLELVDTSTP-KDIKLHEIL 1212
            :.:.||||:.. |||.:|.|:
Zfish  1048 ISVYLVDTTQENKDIWIHNIM 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586	25/86 (29%)
		TUDOR	563..673	CDD:278965	30/126 (24%)
		TUDOR	766..896	CDD:278965	28/135 (21%)
		TUDOR	1032..1151	CDD:278965	38/125 (30%)
		TUDOR	1087..1131	CDD:119391	11/44 (25%)
tdrd7a	NP_001092813.1	LOTUS_1_TDRD7	4..91	CDD:193600	25/86 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..175		6/21 (29%)
		LOTUS_2_TDRD7	206..271	CDD:193587	11/64 (17%)
		LOTUS_3_TDRD7	367..434	CDD:193588	17/75 (23%)
		TUDOR	465..587	CDD:278965	32/144 (22%)
		TUDOR	520..573	CDD:197660	13/65 (20%)
		TUDOR	659..778	CDD:278965	27/128 (21%)
		TUDOR	712..757	CDD:119391	9/49 (18%)
		TUDOR	891..1007	CDD:278965	38/125 (30%)
		TUDOR	945..988	CDD:119391	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I4395
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276848at2759
OrthoFinder	1	1.000	-	-		FOG0005497
OrthoInspector	1	1.000	-	-		otm25227
orthoMCL	1	0.900	-	-		OOG6_106750
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870