DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and rnf17

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_021334643.1	Gene:	rnf17 / 334519	ZFINID:	ZDB-GENE-030131-6451	Length:	1521	Species:	Danio rerio

Alignment Length:	1331	Identity:	247/1331 - (18%)
Similarity:	448/1331 - (33%)	Gaps:	361/1331 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 QKHTHGNKYHYQQRNKQPNHQPDQEIGRAAKCENQAIAEHKQDLTGIITQELFESFNNIQGPFSE 178
            :|...|:|:..|:....|:         :|....:..||.|.|:..::.:.|.::        :|
Zfish    88 KKGHSGDKWKSQKFKSPPS---------SAAVHTEENAEGKPDVVKVLDEALTKA--------TE 135

  Fly   179 NLQVFNKNPEYITRR-KKELKKEDDLDRGQITKEV--AREKQKEKETRDRAVTETIFVTIENKKA 240
            ||...:|..:.:... ..:|:||    |.:|.:|:  |.||.|....:.|::..:...:::
Zfish   136 NLNQLDKLHQTLANGVHGQLRKE----RSRIIREIDEAVEKAKSILLKRRSMLVSTLSSVD---- 192

  Fly   241 PVMNGHGPRHVKVANGQDKHNDGKPPLRAILGNSASQRQQDTSTVY----------HSPESSFKR 295
             ::...|....|....:.|.      ||..:..:...||..:...|          |.|......
Zfish   193 -LLFSGGQMECKRIEERIKE------LRTAIQKARHVRQVPSLETYCDLEKILETLHIPVDLESY 250

  Fly   296 PRHPRVMYPG---HQRTTGV--SVNHRLKVTPQSDAPTPAVAPITP------------------- 336
            ......:..|   |.:..|.  ||...||:|...|........:.|
Zfish   251 DMSSLTLRSGLSCHLQVDGFTESVKVFLKITDTDDNCIVEEITVEPFQHVVKSGVEMWDNSSQSV 315

  Fly   337 ----PASPEYAQTTTAAKATYKED---------IHGGQGETGNV--------------------- 367
                .|.|..:..|........||         ::.|.|....|
Zfish   316 QGKADAIPRKSNNTRRFMEKMMEDTCPEIADTRVNAGLGRNLPVHEPRRMERYNKGYRKQRRPQF 380

  Fly   368 --VTNPKVKVPLKFDPSLDPVSTLNFYCAANDFEKPAYNIFNKLRNLHCSVQIAGDVYSSYPQEF 430
              .|||:.|: :::..:...|:..:||.......|....:..|:... ||.:.:   :.::..|.
Zfish   381 EKPTNPQPKL-VQYVVTTHIVNPGHFYVRYMAEHKLGQKLTKKISEF-CSGERS---FFTFSDEI 440

  Fly   431 TDKETAY-----QRTAQIAIQRIMHAQSHQKLSACTFSDVE-----FID-GLYK----------- 473
            |.....:     ....::.:..:...:..|.::.|..|:|.     |:| |.:|
Zfish   441 TTGSLLFISWKDDMWCRVKVTELFQKECFQSVTKCLASEVSRLCVYFLDYGFFKGFSIPSDGGLS 505

  Fly   474 ---ELLKHPHGILGHKLEDW----YGSTFRQHLPSHWYDLI-----VKSNKIR-VEHGIDPRIIL 525
               |.|:.|.||...::.:|    ...:.:..:|:   ||:     ..|.::| |.......:.:
Zfish   506 GLNECLRRPDGITLIEMANWAPLAIKCSLKDIIPA---DLVKGWSSEASEEMRNVLRNETAEMQV 567

  Fly   526 FANDPGSSEPD--RTSITTLPQMVLPWQSSEGGSHDWNMFIS----FC-----DSTKIVWARMID 579
            |..|..:...|  :||:..|.      ::|.....:..:|:.    :|     .|..:::...:.
Zfish   568 FGEDGDALLVDLKKTSMADLK------KNSMVSLREHLVFMELARFYCPVITTGSAPLLFYPSVQ 626

  Fly   580 QIANFE--ELTKHIG----------RQMESPHFRQKVSKPYAQ-------EVYLVEMPDG----- 620
            ...|.|  .:..|:.          ...|.|....|:...|.|       :||...:...
Zfish   627 PSLNVEVNAMVSHVNTPSDFYVQLVENTEYPLLHSKLQDCYNQPKSNNECQVYCPSLSQACVAFH 691

  Fly   621 ---WNRVRAISVDEETRSGR---YHFIDFGDVAMFHSEDLFHCPPQFLALPAQAV-CLSMYALDK 678
               |:||:.....    .||   ..|:|||.......:||.|...:|..||..|: |.....:..
Zfish   692 DQEWSRVQVTGFP----GGRMVEVRFVDFGYKRTLSVKDLRHIKDEFFVLPEMALWCNLNDVISS 752

  Fly   679 FEDHPHALQVLTKEL-DGQ--TVVAHVLTTEKQ-----FLELGGSAQG------VVENGKRRACL 729
            .|...:......||| :|:  ||||.......:     ..|:.....|      :|:.|
Zfish   753 QETWANEACESFKELVEGKLMTVVAKKNVPSSKPVPVCLFEISDDCTGASIGDELVKKG------ 811

  Fly   730 VATLYDTSTAEDIHLNDLVAKRITKCTP------------APSLSDEKKIGKTTP-------ILV 775
             ..:|:    :|..:.|......|...|            ..|.|:|.|...:.|       :.|
Zfish   812 -YAVYN----KDTQVRDAQPLETTSWDPPFEEEALPVVMTPSSASEELKPSLSLPSCLKDIRVRV 871

  Fly   776 SHINDDGDLMVLLRNDDLKFVERSIAQTVADL---GEQDRVSYSDLLHDRHIFVCDETVDGVKQW 837
            :|:...|::.|.|...|.:.  :.|..|:.:|   .|...:.:...::      |.....||  |
Zfish   872 THVTSPGNICVQLLQFDNQL--KRIHDTLKNLFSKSEPQEMQWEAEMY------CAVNNTGV--W 926

  Fly   838 FRGRLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRLEANNRALATFPPQAIPVRLHDVPEIGG 902
            .||::.:.......|   |...|.|...|.|:.|:..|..:  .:.:|   .:...|..|...||
Zfish   927 ERGQVCSVSTCGVAE---VLRCDFGNTVKLHVDNLRPLHPD--LIGSF---LLECNLSGVRPAGG 983

  Fly   903 H----------MLHRLRGLIPWRTEALLKVVAMDGGKPLVNVFIREDPESMYMCVNIGLRLELEM 957
            .          :.|.|.|.:     ||:.:........||::|          |.|       ..
Zfish   984 RSTWTATACDFISHYLTGAM-----ALMAIKEPSTRPVLVSLF----------CSN-------RA 1026

  Fly   958 ASSIHPEKYDHTLLSSNVQLPRRGSFSSVFSNQSSSSDLVATTP---------PVTPEKK---PS 1010
            ..::   .:...|:|..:.|..|.: ..|||.:|    ::.|.|         |.||.::   |.
Zfish  1027 GQNV---SFADFLISEGLALKERKA-EMVFSEES----VLVTEPQPVISPTQTPPTPSRRINPPP 1083

  Fly  1011 ARSTGSTFSSLMLKDYEAIPAVGAYFEVRVALSVN----PGHFAVQPYKYYNQLQTLMKNLQEHC 1071
            .|....::..      ..:|..|     .:.:|::    .|......::...:...|.:.||:|.
Zfish  1084 ERVKTHSYPP------PELPPCG-----HILMSISAVSEQGVIYAMTHQAVCEFDRLRERLQQHI 1137

  Fly  1072 QKTAA-------KGVQPSQLAIGEAYAAPDSEGVYHRVSIHKIYDEIIHVRFVDVG-DDGVIACD 1128
             ||..       |||      :|.|....|.  .::|..:.::....:.||:||.| .:.:..|.
Zfish  1138 -KTLPRQKNYNWKGV------LGCAVMGTDM--FWYRGQVQEVIGGHVKVRYVDQGLVESIPVCH 1193

  Fly  1129 QLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRELSLGQKFIGIVRRMTKQKDGGRAL 1193
            ....:..|  .:|::.:|.|:.|:......|..:..|..:||.||:..  .|:.|...||....:
Zfish  1194 VYPMVLCE--DVPQLCVPCQINGVLPIGKGWQWDAVVLMKELLLGRSV--NVQIMEHPKDPCGCV 1254

  Fly  1194 CLE-LVDTSTPKDIKLHEILINEKHA--QPA 1221
            .:| :||     .:.|.:|:::.::|  .||
Zfish  1255 TVEIMVD-----GMALSKIMVHHQYATFDPA 1280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586
		TUDOR	563..673	CDD:278965	30/149 (20%)
		TUDOR	766..896	CDD:278965	28/139 (20%)
		TUDOR	1032..1151	CDD:278965	26/130 (20%)
		TUDOR	1087..1131	CDD:119391	10/44 (23%)
rnf17	XP_021334643.1	RING_Ubox	8..60	CDD:327409
		TUDOR	394..534	CDD:306940	23/143 (16%)
		TUDOR	633..746	CDD:306940	25/116 (22%)
		TUDOR	865..977	CDD:306940	26/129 (20%)
		TUDOR	1092..1214	CDD:306940	27/143 (19%)
		TUDOR	1326..1450	CDD:306940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810