DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and Rnf17

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_038949233.1	Gene:	Rnf17 / 305908	RGDID:	1310486	Length:	1650	Species:	Rattus norvegicus

Alignment Length:	1217	Identity:	236/1217 - (19%)
Similarity:	421/1217 - (34%)	Gaps:	329/1217 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DLTGII-TQELFESFNNIQGPFSENLQVFNKNPEYITRRKKE----------LKKEDDLDRGQIT 209
            |||.|| |.:|     |.:...|:...:..:||..:.....|          ::.||........
  Rat   253 DLTQIIRTLKL-----NFESELSQVSSIIPRNPPRLNINCSEVICMFNSMGKIEFEDSTKCHPQE 312

  Fly   210 KEVAREKQKEKETRDRAVTETIFVTIENKKAP--VMNGHGPRHVKVANGQDKHNDG--KPPLRAI 270
            .||.:..||:..::.....: ::.::|.|:..  |:....|.....|...|:|.:|  |.|.:.:
  Rat   313 NEVGQNVQKKFNSKKELCCD-VYSSLEKKRVDTVVLADEAPVPPLQAETPDRHLEGENKQPQKEV 376

  Fly   271 LGNSASQRQQDTSTVYHSP------------ESSF-----KRPRHPRVMYPGHQRTTGVSVNHRL 318
            |..::.:.......:..||            ||.|     :.||:|
  Rat   377 LVVASPKTVAVLPQLGSSPDVIIEEIIEENLESCFTDEPIETPRYP------------------- 422

  Fly   319 KVTPQSDAPTPA-----------VAPITPPAS---PEYAQTTTAA------KATYKEDIHGGQGE 363
            |..||.:...|.           |:.:|.|..   .:|:|...||      |....:.:|....:
  Rat   423 KKPPQKELSAPVASKAGCPELVFVSHVTHPCHFYVRKYSQIKDAAMLEKKMKQVCSKSLHLDPSD 487

  Fly   364 T----GNVVTNPKVK------------VPLKFDPSLDPVSTLNF-YCAAN-------DFEKPAYN 404
            |    ..:..| .:|            :|.|......|.|...| .|..:       ||......
  Rat   488 TLELGARIFVN-SIKNRMWCRGIITEIIPTKTKNVRKPCSPTKFSVCEISLIQIFMVDFGNSEVL 551

  Fly   405 IFNKLRNLHCSVQIAGDVYSSYPQEF---TDKETAYQRTAQIAIQRIMHAQSHQKLSACTFSD-- 464
            |...:.:.|...:..|:.:.:. .:|   ..|...|.......|..:.|..|.:.:.....|:
  Rat   552 IITGVGDTHVGPEHVGEQHITL-SDFCLLVRKSEPYSEELLKDIPHLAHLCSLKDIVPYNSSEGW 615

  Fly   465 -----VEFIDGLYKE--LLKHPHGILGHKLEDWYGSTFRQHLPSHWYDLIV------KSNKIRVE 516
                 |||:..:.|:  |:|    :.|.  ||               |:::      .:|||..:
  Rat   616 EKEAKVEFLKMVNKKAVLMK----VFGE--ED---------------DILIVDLQKPPTNKISSD 659

  Fly   517 HGIDPRIIL-------FANDPGSSEPDRTSITTLPQMVLPWQSSEGGSHDWNMFISFCDSTKIVW 574
            ..:..|..|       |.:....|..:..:........||.:.:|     .::.:...:|....:
  Rat   660 MPVSLRDALVFMELARFRSQSLRSHGENNTALCYRPPALPEEMTE-----VSVMVCHINSPTDFY 719

  Fly   575 ARMIDQIANFEELTKHI--------GRQMESPHFRQKVSKPYAQEVYLVEMPDG-WNRVRAISVD 630
            .::::.: :|..|.|.|        |..:|       :..|...:..:.:..|| |.|.:.|.:.
  Rat   720 LQLMENL-DFLSLLKTIEEFYKGEDGENLE-------ILCPLQNQACVAKFEDGIWYRAKVIGLP 776

  Fly   631 EETRSGRYHFIDFGDVAMFHSEDLFHCPPQFLALPAQAV-C------------LSMYALDKFEDH 682
            .. |.....::|||:.|....:|:.....:||..|.:|: |            .|..|.:|||:
  Rat   777 GH-REVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAFIEPSKRSHWSKKAKEKFEE- 839

  Fly   683 PHALQVLTKELDGQTVVAHVLTTEKQFLELGGSAQGVVENGKRRACLVATLYDT----STAEDIH 743
                                 .|:.:|:..  |...::|||    .|:..|:|:    ::|..|:
  Rat   840 ---------------------KTQDKFVTC--SVIKILENG----VLLVELFDSRAPGTSAVSIN 877

  Fly   744 ----------------LNDLVAKRITKCTPAPSLSDEKKIGKTTPILVSHINDDG-------DLM 785
                            |.|...|.:....|:|......:|...:|:.|:.:.::.       :|.
  Rat   878 EQLVKEGLASYEAGYTLKDNSKKHLEVWDPSPEEIISSEINSLSPLSVNSLANESFQSLYNKELP 942

  Fly   786 VLLRN---DDLKFVERSIAQTVADLGEQDRVSYSDLLH----------DRHIFVCDETVDGVKQW 837
            |.:.|   .:..:|:..:.:.:....|:..|:..:  |          |.|   |...:....||
  Rat   943 VSICNVLSPEKIYVQWLLTENLLTSLEEKMVAAYE--HSEWKPVKWECDMH---CAVKIPAKSQW 1002

  Fly   838 FRG---RLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRLEANNRALATFPPQAIPVRLHDVPE 899
            .||   |:||..|      .:|...|.|.:...:|..:..|:.|   |.|....::...|.|:..
  Rat  1003 RRGQIIRMVTDTL------VEVLLYDVGIELVVNIHCLRELQEN---LKTMGRLSLECSLVDIRP 1058

  Fly   900 IGGHMLHRLRG---LIPWRTEALLKVVAMDGGK--PL-VNVFIRED-----PESMYMCVNIGLRL 953
            .||........   |..:.|.|:..::..:...  || |.:|.|::     ..|.|: :..||.|
  Rat  1059 TGGSDKWTATACDCLSLYLTGAIATIILQENSTTWPLPVKIFCRDEKGERVDVSKYL-IKKGLAL 1122

  Fly   954 ---ELEMASSIH-PEKYDHTLLSSNVQLPRRGS-----FSSVFSNQSSSSDLV-ATTPPVTPEKK 1008
               .:..:|:.| |||      |..:.|.:..|     |...|......:|.| ....|.:.||.
  Rat  1123 RDRRVSKSSNSHSPEK------SLEIPLEQGDSVVTKCFQINFDTNKKIADKVNEHKVPESKEKY 1181

  Fly  1009 PSARSTGSTFSSLMLKDYE--AIPAVGAYFEVRVALSVNPGHFAVQPYKYYNQLQTLMKNLQEHC 1071
            ..:|:.|.         |:  |:|...: ||..|:...:.|...|.|.....:|..:|..:|.:.
  Rat  1182 SESRTNGF---------YKPPAVPNTSS-FEAIVSCIGDDGTIFVVPKLSEFELIKMMDEIQSNL 1236

  Fly  1072 QKTAAKGVQPSQLAIGEAYAAPDSEGVYHRVSIHKIYDEIIHVRFVDVG-DDGVIACDQLKTLNP 1135
            :....  ::|.....||..|...|:.:::|..:.::....|.|:::|.| .:.:..|.    |.|
  Rat  1237 KCLGL--LEPYFWKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCH----LYP 1295

  Fly  1136 EL--RKLPKMALPAQLYG--------IQLTDV--VWSKENCVRFREL 1170
            .|  ...|:..:|.|||.        :..|.|  ||..:.....:||
  Rat  1296 ILLYPDTPQFCIPCQLYQTLPCVCVCVHYTQVGNVWQPDAIELLQEL 1342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586
		TUDOR	563..673	CDD:278965	24/131 (18%)
		TUDOR	766..896	CDD:278965	30/152 (20%)
		TUDOR	1032..1151	CDD:278965	27/121 (22%)
		TUDOR	1087..1131	CDD:119391	10/44 (23%)
Rnf17	XP_038949233.1	PHD_SF	30..72	CDD:419867
		BBC	137..>242	CDD:128778
		Tudor_TDRD4_rpt1	490..566	CDD:410485	12/76 (16%)
		Tudor_TDRD4_rpt2	728..823	CDD:410486	23/102 (23%)
		Tudor_TDRD4_rpt3	968..1049	CDD:410487	22/94 (23%)
		Tudor_TDRD4_rpt4	1247..1314	CDD:410488	18/70 (26%)
		Tudor_TDRD4_rpt5	1504..1608	CDD:410489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810