DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tapas and Tdrd1

DIOPT Version :9

Sequence 1:	NP_611475.3	Gene:	tapas / 37304	FlyBaseID:	FBgn0027529	Length:	1222	Species:	Drosophila melanogaster
Sequence 2:	XP_038959137.1	Gene:	Tdrd1 / 292129	RGDID:	1306140	Length:	1174	Species:	Rattus norvegicus

Alignment Length:	1069	Identity:	226/1069 - (21%)
Similarity:	360/1069 - (33%)	Gaps:	302/1069 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 ENKKAPVMNGHGP--RHVKVANGQDKHNDGKPPLRAILGNSASQ---RQQDTSTVYHSPESSFKR 295
            ::.::||...:.|  |.....||..|:|       .:|.....|   .|:|.|.|..:|
  Rat    31 DSLRSPVPQHNHPNFRLKSPENGNKKNN-------FLLCEQNKQYLASQEDNSVVSSNP------ 82

  Fly   296 PRHPRVMYPGHQRTTGVSVNHRLKVTPQSDAPTPAVAPITPP----ASPEYAQTTTAAKATYKED 356
                    .|.....|.|...| |..|..:..:.::...:||    ..|..|.|...:|.::|
  Rat    83 --------AGINGEVGGSKGDR-KTLPTGNPVSLSLGNNSPPNQVKTKPSNAVTPEKSKKSHK-- 136

  Fly   357 IHGGQGETGNVVTNPKVKVPLKFDPSLDPV--STLNFYCAANDFEKPAYNIFNKLRNLHCSVQIA 419
                ..|....|.||.:     |: ||.|.  ||....|          .:|..||...|
  Rat   137 ----LFENALSVNNPAL-----FN-SLGPPLRSTTCHRC----------GLFGSLRCSQC----- 176

  Fly   420 GDVYSSYPQEFTDKETAYQRTAQIAIQRIMHAQSHQKLSACTFSDVEFIDGLYKELLKHPHGILG 484
                         |:|.|..|   |.|| ....||..:.......:
  Rat   177 -------------KQTYYCST---ACQR-RDWSSHSTICRPVQQSL------------------- 205

  Fly   485 HKLEDWYGSTFRQHLPSHWYDLIVKSNKIRVEHGIDPRI------ILFANDPGSSEPDRTSITTL 543
            |||||       ...|.....:.||:.::....|:...:      ::|:        |..|:...
  Rat   206 HKLED-------NKSPFETKTIDVKNEQVACPLGVTKEMTAGAERVMFS--------DLRSLQLR 255

  Fly   544 PQMVLPWQSSEGGSHDWNMFISFCDSTKIVWARMIDQIANFEELTKHIGRQMESPHFRQKVSKPY 608
            ..|.:....:| ..|..:.::....|..:.:...:.  |:.:|  .:.....|..:.      |.
  Rat   256 KSMEIKGTVTE-FKHPGHFYVQLYSSEVLEYMNQLS--ASLKE--TYANMVPEDGYL------PV 309

  Fly   609 AQEV----YLVEMPDGWNRVRAISVDEETRSGRYHFIDFGD-----VAMFH----SEDLFHCPPQ 660
            ..||    |.|:..  |||.....||...:.....:||:|:     |...|    |..||  ||.
  Rat   310 KGEVCVAKYTVDQT--WNRAVVEGVDVLQKKAHVLYIDYGNEEIIPVDRIHQLSRSISLF--PPS 370

  Fly   661 FL------ALPA------------QAVCLSMYALDKFEDHPH----------ALQVLTKELDGQT 697
            .:      .:||            :|:....|...|..|...          .||...|:||
  Rat   371 AIKCYVSGVVPAAGEWTEDCVVAVKALLFEQYCSIKVVDISEEEGLTCAVDVVLQSSGKQLD--- 432

  Fly   698 VVAHVLTTEKQFLELGGSAQGVVENGKRRACLVATLYDTS--TAEDIHLNDLVAKRITKCTPAPS 760
               |||      :|:|...:....:.|:::....|..||.  |||    |.:.|:|........:
  Rat   433 ---HVL------VEMGYGVKPDEPSSKKQSMDPGTSEDTGRLTAE----NRIGAERNALVPTVLT 484

  Fly   761 LSDEKKIGKTTPILVSHINDDGDLMV--LLRNDDLKFVERSIAQTVADLGEQDRVSYSDLLHDRH 823
            |:    :|.....:|:||....|...  |.....|..::.|:::..:.:  ..|..:...:.|
  Rat   485 LN----VGDEFCGVVAHIQTPEDFFCQQLQSGHKLAELQESLSEYCSHV--TPRSDFYPTIGD-- 541

  Fly   824 IFVCDETVDGVKQWFRGRLVTRPLNPDEESFDVYYVDDGRQRKAHISNIYRLEANNRALATFPPQ 888
              :|........||:|..::.   ...|||..|.|||.|   ...|.::.||......|...|.|
  Rat   542 --MCCAQFSEDDQWYRASVLA---YASEESVLVGYVDYG---NFEILSLKRLCPIIPKLLDLPMQ 598

  Fly   889 AIPVRLHDV-PEIGGHMLHRLRGLIPWRTEAL-------------LKVVAMDGGKPLVNVFIRED 939
            |:...|..| |.:|           .|..||:             ::||.|.|.:.||.:
  Rat   599 ALNCVLAGVKPSLG-----------MWTPEAICVMRKAVQNRMVTVRVVGMQGTRALVEL----- 647

  Fly   940 PESMYMCVNIGLRLELEMASSIHPEKYDHTLLSSNVQLPRRGSFSSVFSNQSSSSDLVATTPPVT 1004
                         ::..:|..:...|   .||.|...:..:              |:||
  Rat   648 -------------VDKSVAPHLSASK---ALLDSGFAIEEK--------------DIVA------ 676

  Fly  1005 PEKKPSARSTGSTFSSLMLKDYEAIP---------AVGAYFEVRVALSVNPGHFAVQPYK--YYN 1058
             :|..|||:     |::.|....|:.         .|....:|.|.:..:||.|.....|  ...
  Rat   677 -DKGSSARA-----SNVPLAVEGAVEVLEWTWVEFTVDETVDVMVCMMHSPGEFYCHCLKDDALK 735

  Fly  1059 QLQTLMKNLQEHCQKTAAKGVQPSQLAIGE-AYAAPDSEGVYHRVSIHKIYDE-IIHVRFVDVGD 1121
            :|..|.|:|.::|.:....|.:..   :|. ..|....:|.::|..:.:|... .:.|.|||.|:
  Rat   736 KLDDLNKSLADYCAQKPPNGFKAE---VGRPCCACFAGDGNWYRALVKEILPSGNVKVHFVDYGN 797

  Fly  1122 DGVIACDQLKTLNPELRKLPKMALPAQLYGIQLTDVVWSKENCVRFRELSLGQKFIGIVRRMTKQ 1186
            ...:..|||..:.|:...||...:...|..||..:..|:||...||:...:|.|....|..:|:.
  Rat   798 VEEVTTDQLHAIAPQFLLLPFQGMQCWLVDIQPKNKHWTKEATARFQACVVGLKLQARVVEITEN 862

  Fly  1187 KDGGRALCLELVDTSTPKDIKLHEILINE 1215
            ..|     :||.|.|||....:.::||.|
  Rat   863 GVG-----VELTDLSTPYPKIISDVLITE 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tapas	NP_611475.3	LOTUS_TDRD_OSKAR	7..92	CDD:193586
		TUDOR	563..673	CDD:278965	27/140 (19%)
		TUDOR	766..896	CDD:278965	30/131 (23%)
		TUDOR	1032..1151	CDD:278965	30/122 (25%)
		TUDOR	1087..1131	CDD:119391	12/45 (27%)
Tdrd1	XP_038959137.1	zf-MYND	162..198	CDD:396356	14/67 (21%)
		Tudor_TDRD1_rpt1	262..391	CDD:410479	28/143 (20%)
		Tudor_TDRD1_rpt2	512..593	CDD:410480	19/92 (21%)
		TUDOR	709..825	CDD:395449	28/118 (24%)
		Tudor_SF	938..1053	CDD:413384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910